ovalbumin and Measles

Five patients with atopic dermatitis (AD) who were sensitive to hen's egg were observed before and after natural measles virus infection. Within 4 weeks of natural measles virus infection, the eczematous lesions clearly improved in four of the five patients in whom neither offending foods were eliminated, nor anti-allergic drugs, systemic steroids and steroid ointment administered. This was accompanied by reduced proliferative responses of peripheral blood mononuclear cells (PBMCs) to ovalbumin (OA). Another patient showed a transient improvement of AD symptoms, from severe to mild, and thereafter returned to severe accompanied by increased proliferative responses of PBMCs to OA. Radioallergosorbent test (RAST) scores for hen's egg in all five patients did not change in each level in each patient, except the transiently decreased RAST scores for hen's egg in one patient, after the infection. Thus, in patients with AD who are sensitive to food, the improvement of AD symptoms that appeared within 4 weeks of natural measles virus infection was related to reduced proliferative responses of PBMCs to the food antigen following the infection.

Topics: Antigens; Child; Child, Preschool; Dermatitis, Atopic; Double-Blind Method; Eggs; Food Hypersensitivity; Humans; Infant; Leukocytes, Mononuclear; Lymphocyte Activation; Measles; Measles virus; Ovalbumin

Topics: Child, Preschool; Eggs; Evaluation Studies as Topic; Food Hypersensitivity; Humans; Immunoglobulin E; Measles; Measles Vaccine; Ovalbumin

A guinea pig model of mild measles virus infection was established by the intranasal inoculation with Toyoshima strain. The infection was confirmed by the development of both humoral and cell-mediated immunities to measles virus as well as by the demonstration of transient virus growth in the lymphoid tissues. The virus infection caused a transient suppression of delayed hypersensitivity to purified protein derivative (PPD) at both the induction and expression phases, whereas Jones-Mote-type hypersensitivity to ovalbumin developed in a normal fashion. In the virus-infected animals, the suppressed response to the skin reacting factor was observed as well, however in vitro responsiveness of lymphocytes to PPD was not suppressed. On the other hand, transient enhancement of skin reactivity to phytohemagglutinin by virus infection was noticed. These results may indicate subtle alterations of immune functions in guinea pigs during measles virus infection.

Topics: Animals; Antibody Formation; Guinea Pigs; Hypersensitivity, Delayed; Immune Tolerance; Immunity, Cellular; Lymphocytes; Measles; Ovalbumin; Phytohemagglutinins; Skin; Tuberculin Test

Topics: Animals; B-Lymphocytes; Chickens; Dinitrophenols; Fluorescent Antibody Technique; gamma-Globulins; Humans; Immune Sera; Immunization; Immunization, Passive; Immunosuppression Therapy; Iodine Radioisotopes; Lethal Dose 50; Lymphocyte Transfusion; Measles; Measles virus; Mice; Ovalbumin; Phenylacetates; Precipitin Tests; Radiation Chimera; Sindbis Virus; Spleen; Subacute Sclerosing Panencephalitis; T-Lymphocytes; Transplantation, Homologous; Virus Replication