ovalbumin has been researched along with Irritable-Bowel-Syndrome* in 3 studies
3 other study(ies) available for ovalbumin and Irritable-Bowel-Syndrome
| Article | Year |
|---|---|
Colonic Mucosal Immune Activation in Mice with Ovalbumin-Induced Allergic Airway Disease: Association between Allergic Airway Disease and Irritable Bowel Syndrome.
Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response. Topics: Administration, Intranasal; Albuterol; Animals; Disease Models, Animal; Inflammation; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Respiratory Hypersensitivity | 2021 |
Local immune response to food antigens drives meal-induced abdominal pain.
Up to 20% of people worldwide develop gastrointestinal symptoms following a meal Topics: Abdominal Pain; Adult; Allergens; Animals; Citrobacter rodentium; Diarrhea; Enterobacteriaceae Infections; Female; Food; Food Hypersensitivity; Glutens; Humans; Immunoglobulin E; Intestinal Mucosa; Intestines; Irritable Bowel Syndrome; Male; Mast Cells; Mice; Mice, Inbred BALB C; Middle Aged; Milk; Ovalbumin; Quality of Life; Receptors, Histamine H1; Soybean Proteins; Triticum | 2021 |
An Allergic Basis for Abdominal Pain.
Topics: Abdominal Pain; Animals; Citrobacter rodentium; Disease Models, Animal; Enterobacteriaceae Infections; Food Hypersensitivity; Humans; Immunoglobulin E; Irritable Bowel Syndrome; Mast Cells; Mice; Ovalbumin | 2021 |