The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa, 2021, Volume: 27Childhood trauma may contribute to poorer premorbid social and academic adjustment which may be a risk factor for schizophrenia.. We explored the relationship between premorbid adjustment and childhood trauma, timing of childhood trauma's moderating role as well as the association of clinical and treatment-related confounders with premorbid adjustment.. Type of childhood trauma was assessed with the Childhood Trauma Questionnaire, short-form and premorbid adjustment using the Premorbid Adjustment Scale. Timing of childhood trauma was assessed using the Life Events Checklist and life events timeline. Linear regression analyses were used to assess the moderating effect of timing of childhood trauma. Clinical and treatment-related confounders were entered into sequential hierarchical regression models to identify independent predictors of premorbid adjustment across key life stages.. Childhood physical neglect was associated with poorer premorbid academic functioning during childhood and early adolescence, and poorer premorbid social functioning during early and late adolescence. By hierarchical regression modelling (. In patients with FES, childhood physical neglect may contribute to poorer premorbid social functioning during early adolescence. This may provide us with an opportunity to identify and treat at-risk individuals earlier.. Utilization of pharmacy services including telehealth, may allow clinical pharmacists to collaboratively provide remote services without jeopardizing patient outcomes. Larger studies are needed to confirm these findings, and display the long-term impact and satisfaction of these services.. Treatment of Staphylococcus aureus IE in IDUs on methadone treatment requires the use of high daptomycin daily doses in order to achieve satisfactory pharmacodynamic parameters. Close monitoring of the daptomycin plasma concentration is suggested. Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antineoplastic Agents, Alkylating; Area Under Curve; Atherosclerosis; B7-H1 Antigen; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Calgranulin B; Cause of Death; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Combined Modality Therapy; Comorbidity; Cost-Benefit Analysis; COVID-19; COVID-19 Vaccines; CRISPR-Cas Systems; Daptomycin; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Drug Therapy, Combination; Endocarditis, Bacterial; Enzyme Inhibitors; Extracellular Matrix; Female; Ferritins; Fibrin Fibrinogen Degradation Products; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Gene Targeting; Glioblastoma; Half-Life; Health Status; Heterocyclic Compounds, 1-Ring; Hospital Mortality; Humans; Interleukin-6; L-Lactate Dehydrogenase; Lung; Lung Diseases, Interstitial; Male; Matrix Metalloproteinase 13; Methadone; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbial Sensitivity Tests; Microglia; Middle Aged; Neuroendocrine Tumors; Octreotide; Opiate Substitution Treatment; Ovalbumin; Oxygen; Oxygen Inhalation Therapy; p38 Mitogen-Activated Protein Kinases; Parkinson Disease; Partial Pressure; Phenotype; Plaque, Atherosclerotic; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Prospective Studies; Quality of Life; Radiotherapy Dosage; Radiotherapy, Conformal; SARS-CoV-2; Severity of Illness Index; Spike Glycoprotein, Coronavirus; Staphylococcal Infections; Staphylococcus aureus; Surveys and Questionnaires; Survival Rate; Sweden; Temozolomide; Tissue Distribution; Tomography, X-Ray Computed; Treatment Outcome; Tumor-Associated Macrophages; Young Adult | 2021 |