ovalbumin and Adrenal-Insufficiency

Asthma is a common respiratory disease currently affecting more than 300 million worldwide and is characterized by airway inflammation, hyperreactivity, and remodeling. It is a heterogeneous disease consisting of corticosteroid-sensitive T-helper cell type 2-driven eosinophilic and corticosteroid-resistant, T-helper cell type 17-driven neutrophilic phenotypes. One pathway recently described to regulate asthma pathogenesis is cholesterol trafficking. Scavenger receptors, in particular SR-BI (scavenger receptor class B type I), are known to direct cellular cholesterol uptake and efflux. We recently defined SR-BI functions in pulmonary host defense; however, the function of SR-BI in asthma pathogenesis is unknown. To elucidate the role of SR-BI in allergic asthma, SR-BI-sufficient (SR-BI

Topics: Adrenal Insufficiency; Animals; Asthma; CD36 Antigens; Hypersensitivity; Inflammation; Interleukin-17; Lung; Male; Mice, Inbred C57BL; Neutrophils; Ovalbumin; Pyroglyphidae; Th17 Cells

Topics: Adrenal Insufficiency; Adrenalectomy; Adrenocortical Hyperfunction; Anaphylaxis; Antigens; Haemophilus; Ovalbumin; Periodicity; Research; Vaccines