Compounds > ouabain

ouabain and Bipolar Disorder

ouabain has been researched along with Bipolar Disorder in 67 studies

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199018 (26.87)18.7374
1990's4 (5.97)18.2507
2000's11 (16.42)29.6817
2010's27 (40.30)24.3611
2020's7 (10.45)2.80

Authors

AuthorsStudies
Hoai Nguyen, BC; Jeong, JH; Kim, DJ; Kim, HC; Lichtstein, D; Nabeshima, T; Nah, SY; Nguyen, BT; Sharma, N; Shin, EJ; Tran, NKC1
El-Mallakh, RS; Gao, Y; Hamlyn, J; Roberts, M1
Aguiar-Geraldo, JM; Cararo, JH; da-Rosa, DD; Peper-Nascimento, J; Possamai-Della, T; Quevedo, J; Valvassori, SS1
Abaimov, D; Budygin, E; Deal, A; Evdokimenko, A; Fedorova, T; Gainetdinov, R; Kazanskaya, R; Lopachev, A; Lopacheva, O; Timoshina, Y; Volnova, A1
Dal-Pont, GC; Gava, FF; Quevedo, J; Resende, WR; Tye, SJ; Valvassori, SS; Varela, RB1
Fedorova, OV; Horesh, N; Ilani, A; Lichtstein, D; Rosen, H; Singh, SV; Wei, W1
Budni, J; Dal-Pont, GC; Gava, FF; Mina, FG; Quevedo, J; Resende, WR; Valvassori, SS; Varela, RB1
Çiçekli, MN; Günaydın, C; Kukula, O; Şafak, S1
Cararo, JH; Carvalho, AF; Dal-Pont, GC; Gava, FF; Mina, FG; Peterle, BR; Quevedo, J; Resende, WR; Valvassori, SS; Varela, RB1
Cohen Ben-Ami, H; Hodes, A; Lichtstein, D; Lifschytz, T; Rosen, H1
Huang, ACW; Tsai, ML; Wang, YC; Yu, YH1
Bianchini, G; Dal-Pont, GC; Gava, FF; Peterle, BR; Quevedo, J; Resende, WR; Trajano, KS; Valvassori, SS; Varela, RB1
Huang, AC; Huang, CL; Wang, CC; Wang, EN; Wang, YC2
Boeira, SP; Bortolatto, CF; Jesse, CR; Nogueira, CW; Souza, LC; Wilhelm, EA1
Arent, CO; Budni, J; Jornada, LK; Kapczinski, F; Mariot, E; Quevedo, J; Steckert, AV; Tonin, PT; Valvassori, SS; Varela, RB1
Lopes-Borges, J; Mariot, E; Quevedo, J; Teixeira, AL; Tonin, PT; Valvassori, SS; Varela, RB1
Gonçalves, CL; Lopes-Borges, J; Quevedo, J; Streck, EL; Tonin, PT; Valvassori, SS; Varela, RB; Vieira, JS1
Amboni, RT; Bianchini, G; Dal-Pont, GC; Lopes-Borges, J; Mariot, E; Quevedo, J; Valvassori, SS; Varela, RB1
Dal-Pont, GC; de Souza, CT; Lopes-Borges, J; Luz, G; Mariot, E; Quevedo, J; Resende, WR; Valvassori, SS; Vitto, MF1
Adham, N; El-Mallakh, RS; Gao, Y; Gyertyán, I; Kiss, B; Lei, Z; Payne, RS; Schurr, A1
Arent, CO; Carvalho, AF; Dal-Pont, GC; Lopes-Borges, J; Mariot, E; Quevedo, J; Resende, WR; Steckert, AV; Valvassori, SS; Varela, RB1
Amodeo, DA; Dwivedi, Y; Grospe, G; Ragozzino, ME; Zang, H1
Deutsch, J; Einat, H; Hodes, A; Lichtstein, D; Lifschytz, T; Rosen, H1
Carvalho, AF; Dal-Pont, GC; de Souza, CT; Farias, HR; Jornada, LK; Machado, AG; Peterle, BR; Quevedo, J; Resende, WR; Valvassori, SS1
Dal-Pizzol, F; de Souza, B; Elias, G; Gavioli, EC; Petronilho, F; Quevedo, J; Réus, GZ; Riegel, RE; Steckert, AV; Valvassori, SS1
El-Mallakh, RS; Gao, Y; Hamid, H; Hougland, MT; Lei, Z1
El-Mallakh, RS; Ginns, E; Huff, MO; Li, XP1
Corrêa, C; Ferreira, GK; Freitas, TP; Moretti, M; Quevedo, J; Rezin, GT; Santos, PM; Scaini, G; Streck, EL; Valvassori, SS1
Arent, CO; Ferreira, CL; Fries, GR; Jornada, LK; Kapczinski, F; Moretti, M; Padilha, PT; Quevedo, J; Valvassori, SS1
El-Mallakh, RS; Huang, X; Lei, Z; Li, XP1
Andrade, VM; Arent, CO; Damiani, AA; Ferreira, CL; Hainzenreder, G; Jornada, LK; Leffa, D; Moretti, M; Quevedo, J; Valvassori, SS1
Freitas, TP; Gomes, LM; Gonçalves, CL; Jeremias, GC; Quevedo, J; Rezin, GT; Scaini, G; Streck, EL; Teodorak, BP; Valvassori, SS1
Arent, CO; Dal-Pizzol, F; Ferreira, CL; Jornada, LK; Mina, F; Moretti, M; Quevedo, J; Steckert, AV; Valvassori, SS1
Brocardo, PS; Budni, J; Dafre, AL; Franco, JL; Pavesi, E; Rodrigues, AL; Terenzi, MG; Trevisan, R; Uliano-Silva, M1
Banerjee, P; El-Mallakh, RS; Gao, Y; Herman, L; Hougland, T; Lei, Z; Lord, J; Payne, RS; Schurr, A1
Brüning, CA; Luchese, C; Nogueira, CW; Pinton, S; Prigol, M1
Decker, S; El-Mallakh, RS; El-Masri, MA; Huff, MO; Levy, RS; Li, XP1
El-Mallakh, RS; Li, R1
Avila, TT; Kapczinski, F; Machado-Vieira, R; Portela, LV; Schmidt, AP; Soares, JC; Souza, DO1
Galili, D; Goldstein, I; Levy, T; Lichtstein, D; Ovadia, H; Rosen, H; Yirmiya, R1
Decker, S; El-Mallakh, RS; El-Masri, MA; Huff, MO; Levy, RS; Li, XP; Morris, M1
El-Mallakh, RS; Huang, X; Lei, Z1
El-Mallakh, RS; Herman, L; Hougland, T1
Crichton, DN; Loudon, JB; Morten, JE; Steel, CM; Wright, AF1
Grof, P; Rathbone, MP; Werstiuk, ES2
Allen, JR; Gershon, E; Jimerson, DC; Nurnberger, J; Simmons, S1
Potok, E; Rybakowski, J; Strzyzewski, W1
Lapierre, Y; Thakar, J; Waters, B1
Potok, E; Rybakowski, J; Strzyzewski, W; Zelechowska-Ruda, E1
Naylor, GJ1
Diamond, JM; Ehrlich, BE1
Dick, P; Gaillard, JM; Tissot, R; Widmer, J1
Christo, PJ; el-Mallakh, RS1
Changaris, DG; el-Mallakh, RS; Harrison, LT; Levy, RS; Li, R1
Changaris, DG; el-Mallakh, RS; Harrison, L; Levy, RS; Li, R1
Cobb, M; Decker, S; El-Mallakh, RS; Grider, G; Huff, MO; Levy, RS; Li, XP1
Dick, DA; Dick, EG; Naylor, GJ; Reid, AH1
Dick, DA; Dick, EG; Naylor, GJ1
Boardman, LJ; Dick, DA; Dick, EG; Dick, P; Naylor, GJ; Smith, A1
Casper, RC; Davis, JM; Dorus, E; Haas, M; Ostrow, DG; Pandey, GN; Tosteson, DC1
Davis, JM; Dorus, E; Pandey, GN; Tosteson, DC1
Aronson, JK; Clarke, EE; Cowen, PJ; Grahame-Smith, DG; Smith, CE; Wood, AJ1
Dick, DA; Dick, EG; Le Poidevin, D; Naylor, GJ; Whyte, SF1
Dick, DA; Dick, EG; Moody, JP; Naylor, GJ1
Hokin-Neaverson, M; Lewis, WC; Spiegel, DA1

Reviews

2 review(s) available for ouabain and Bipolar Disorder

ArticleYear
Mimicking human bipolar ion dysregulation models mania in rats.
    Neuroscience and biobehavioral reviews, 2007, Volume: 31, Issue:6

    Topics: Animals; Bipolar Disorder; Cardenolides; Disease Models, Animal; Enzyme Inhibitors; Humans; Hyperkinesis; Injections, Intraventricular; Ion Transport; Ouabain; Rats; Sodium-Potassium-Exchanging ATPase

2007
Lithium, membranes, and manic-depressive illness.
    The Journal of membrane biology, 1980, Volume: 52, Issue:3

    Topics: Adenylyl Cyclases; Animals; Biological Transport; Bipolar Disorder; Blood-Brain Barrier; Calcium; Cations; Chemical Phenomena; Chemistry; Choline; Epithelium; Erythrocyte Membrane; Erythrocytes; Humans; Intestinal Absorption; Kidney; Kinetics; Lithium; Magnesium; Membrane Potentials; Muscles; Neurons; Ouabain; Potassium; Salivary Glands; Sodium; Tryptophan

1980

Trials

2 trial(s) available for ouabain and Bipolar Disorder

ArticleYear
Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium.
    Psychological medicine, 1976, Volume: 6, Issue:2

    Topics: Adenosine Triphosphatases; Bipolar Disorder; Carrier Proteins; Cell Membrane Permeability; Clinical Trials as Topic; Erythrocyte Membrane; Erythrocytes; Humans; Lithium; Ouabain; Potassium; Recurrence; Sodium

1976
Lithium therapy and erythrocyte membrane cation carrier.
    Psychopharmacologia, 1974, Jun-18, Volume: 37, Issue:1

    Topics: Adenosine Triphosphatases; Bipolar Disorder; Cations, Monovalent; Cell Membrane; Erythrocytes; Female; Humans; Hydrocortisone; Lithium; Male; Ouabain; Placebos; Potassium; Sodium

1974

Other Studies

63 other study(ies) available for ouabain and Bipolar Disorder

ArticleYear
Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2021, Volume: 158

    Topics: Androstanols; Animals; Bipolar Disorder; Dextromethorphan; Disease Models, Animal; Locomotion; Male; Mice; Ouabain; Signal Transduction

2021
Sleep deprivation is associated with increased circulating levels of endogenous ouabain: Potential role in bipolar disorder.
    Psychiatry research, 2022, Volume: 309

    Topics: Animals; Bipolar Disorder; Humans; Hypertension; Mice; Ouabain; Sleep Deprivation; Sodium-Potassium-Exchanging ATPase

2022
Depressive-like behavior accompanies neuroinflammation in an animal model of bipolar disorder symptoms induced by ouabain.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 219

    Topics: Adenosine Triphosphatases; Animals; Behavior, Animal; Bipolar Disorder; Disease Models, Animal; Male; Mania; Neuroinflammatory Diseases; Ouabain; Rats; Rats, Wistar

2022
Intracerebroventricular injection of ouabain causes mania-like behavior in mice through D2 receptor activation.
    Scientific reports, 2019, 10-30, Volume: 9, Issue:1

    Topics: Animals; Behavior, Animal; Bipolar Disorder; Corpus Striatum; Disease Models, Animal; Dopamine; Glycogen Synthase Kinase 3 beta; Humans; Male; Mice; Ouabain; Receptors, Dopamine D2; Sodium-Potassium-Exchanging ATPase

2019
HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain.
    Pharmacology, biochemistry, and behavior, 2020, Volume: 193

    Topics: Animals; Behavior, Animal; Bipolar Disorder; Butyric Acid; Corpus Striatum; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferases; Frontal Lobe; Hippocampus; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Locomotion; Male; Mania; Ouabain; Rats; Rats, Wistar; Signal Transduction; Treatment Outcome; Valproic Acid

2020
Na
    International journal of molecular sciences, 2020, Aug-17, Volume: 21, Issue:16

    Topics: Adult; Bipolar Disorder; Bufanolides; Female; Humans; Male; Middle Aged; Ouabain; Prefrontal Cortex; Protein Isoforms; Sodium-Potassium-Exchanging ATPase

2020
Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model.
    Journal of affective disorders, 2021, 03-01, Volume: 282

    Topics: Animals; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cognition; Disease Models, Animal; Hippocampus; Humans; Ouabain; Rats; Rats, Wistar; Signal Transduction

2021
Role of TRPV1 channels on glycogen synthase kinase-3β and oxidative stress in ouabain-induced bipolar disease.
    Journal of receptor and signal transduction research, 2022, Volume: 42, Issue:4

    Topics: Animals; Antioxidants; Bipolar Disorder; Capsaicin; Glycogen Synthase Kinase 3 beta; Mania; Ouabain; Oxidants; Oxidative Stress

2022
Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain.
    The international journal of neuropsychopharmacology, 2017, 11-01, Volume: 20, Issue:11

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Bipolar Disorder; Brain; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Lithium; Locomotion; Male; Ouabain; Protein Kinase C; Rats; Rats, Wistar; Tamoxifen

2017
Reduction in endogenous cardiac steroids protects the brain from oxidative stress in a mouse model of mania induced by amphetamine.
    Brain research bulletin, 2018, Volume: 137

    Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Antibodies; Antioxidants; Bipolar Disorder; Brain; Central Nervous System Stimulants; Disease Models, Animal; Male; Mice, Inbred BALB C; Motor Activity; Neuroprotective Agents; Ouabain; Oxidative Stress; Random Allocation

2018
Motor function in an animal model with ouabain-induced bipolar disorder and comorbid anxiety behavior.
    Psychiatry research, 2018, Volume: 268

    Topics: Akathisia, Drug-Induced; Animals; Anxiety; Behavior, Animal; Bipolar Disorder; Comorbidity; Disease Models, Animal; Male; Ouabain; Psychomotor Performance; Rats; Rats, Wistar

2018
Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain.
    Journal of psychiatric research, 2019, Volume: 113

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Brain; Disease Models, Animal; Male; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators; Tamoxifen

2019
Effects of lithium and carbamazepine on spatial learning and depressive behavior in a rat model of bipolar disorder induced by ouabain.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 105

    Topics: Animals; Bipolar Disorder; Carbamazepine; Depression; Disease Models, Animal; Learning; Lithium; Male; Ouabain; Rats; Rats, Wistar

2013
Dissociating effects of spatial learning from locomotor activity for ouabain-induced bipolar disorder-like rats.
    Psychiatry research, 2014, May-30, Volume: 216, Issue:3

    Topics: Animals; Bipolar Disorder; Cognition; Disease Models, Animal; Male; Maze Learning; Motor Activity; Ouabain; Rats; Rats, Wistar; Space Perception; Swimming

2014
The protective effect of melatonin against brain oxidative stress and hyperlocomotion in a rat model of mania induced by ouabain.
    Behavioural brain research, 2014, Sep-01, Volume: 271

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Catalase; Cerebral Cortex; Disease Models, Animal; Glutathione Peroxidase; Hippocampus; Lithium Chloride; Locomotion; Male; Melatonin; Motor Activity; Neuroprotective Agents; Ouabain; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase

2014
Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania.
    Molecular neurobiology, 2015, Volume: 52, Issue:1

    Topics: Animals; Bipolar Disorder; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Hippocampus; Humans; Injections, Intraventricular; Male; Motor Activity; Neuroprotection; Ouabain; Oxidative Stress; Rats, Wistar; Thiobarbituric Acid Reactive Substances

2015
Effects of ouabain on cytokine/chemokine levels in an animal model of mania.
    Journal of neuroimmunology, 2014, Nov-15, Volume: 276, Issue:1-2

    Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Cytokines; Disease Models, Animal; Exploratory Behavior; Injections, Intraventricular; Male; Ouabain; Rats

2014
Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 128

    Topics: Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Brain; Butyric Acid; Citric Acid Cycle; Disease Models, Animal; Energy Metabolism; Exploratory Behavior; Histone Deacetylase Inhibitors; Lithium; Male; Motor Activity; Ouabain; Rats; Rats, Wistar; Valproic Acid

2015
Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats.
    Journal of psychiatric research, 2015, Volume: 61

    Topics: Affect; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Butyric Acid; Disease Models, Animal; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Histamine Antagonists; Lithium Compounds; Locomotion; Male; Motor Activity; Nerve Growth Factor; Ouabain; Prefrontal Cortex; Rats; Rats, Wistar; Treatment Outcome; Valproic Acid

2015
Effects of mood stabilizers on oxidative stress-induced cell death signaling pathways in the brains of rats subjected to the ouabain-induced animal model of mania: Mood stabilizers exert protective effects against ouabain-induced activation of the cell de
    Journal of psychiatric research, 2015, Volume: 65

    Topics: Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Cell Death; Disease Models, Animal; Drug Interactions; Enzyme Inhibitors; Injections, Intraventricular; Male; Mitochondria; Motor Activity; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Superoxides; Thiobarbituric Acid Reactive Substances

2015
Cariprazine delays ouabain-evoked epileptiform spikes and loss of activity in rat hippocampal slices.
    Psychiatry research, 2015, Sep-30, Volume: 229, Issue:1-2

    Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Evoked Potentials; Hippocampus; Male; Ouabain; Piperazines; Rats; Rats, Sprague-Dawley

2015
Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain.
    Psychiatry research, 2016, Jan-30, Volume: 235

    Topics: Animals; Antimanic Agents; Antioxidants; Bipolar Disorder; Brain; Butyric Acid; Catalase; Disease Models, Animal; Hippocampus; Hyperkinesis; Male; Ouabain; Oxidative Stress; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2016
Cognitive flexibility impairment and reduced frontal cortex BDNF expression in the ouabain model of mania.
    Neuroscience, 2017, 03-14, Volume: 345

    Topics: Animals; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Down-Regulation; Feedback, Psychological; Frontal Lobe; Male; Maze Learning; Motor Activity; Ouabain; Probability Learning; Rats, Long-Evans; Reversal Learning; RNA, Messenger

2017
Endogenous cardiac steroids in animal models of mania.
    Bipolar disorders, 2016, Volume: 18, Issue:5

    Topics: Animals; Antibodies; Behavior, Animal; Bipolar Disorder; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Frontal Lobe; Mice; Ouabain; Phosphorylation

2016
Lithium and valproate act on the GSK-3β signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Frontal Lobe; Glycogen Synthase Kinase 3 beta; Hippocampus; Lithium Compounds; Locomotion; Male; Ouabain; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; Thiazoles; Urea; Valproic Acid

2017
Animal model of mania induced by ouabain: Evidence of oxidative stress in submitochondrial particles of the rat brain.
    Neurochemistry international, 2009, Volume: 55, Issue:7

    Topics: Animals; Bipolar Disorder; Brain Chemistry; Injections, Intraventricular; Male; Mitochondria; Motor Activity; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Superoxides; Thiobarbituric Acid Reactive Substances

2009
Effect of ouabain on sodium pump alpha-isoform expression in an animal model of mania.
    Progress in neuro-psychopharmacology & biological psychiatry, 2009, Oct-01, Volume: 33, Issue:7

    Topics: Animals; Bipolar Disorder; Brain; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Injections, Intraventricular; Male; Ouabain; Protein Isoforms; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase

2009
Effect of ethacrynic acid on the sodium- and potassium-activated adenosine triphosphatase activity and expression in Old Order Amish bipolar individuals.
    Journal of affective disorders, 2010, Volume: 123, Issue:1-3

    Topics: Adult; Aged; Aged, 80 and over; Bipolar Disorder; Blotting, Western; Cell Line; Enzyme Inhibitors; Ethacrynic Acid; Ethnicity; Female; Humans; Lymphocytes; Male; Middle Aged; Ouabain; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase

2010
Evaluation of brain creatine kinase activity in an animal model of mania induced by ouabain.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:2

    Topics: Animals; Bipolar Disorder; Corpus Striatum; Creatine Kinase, BB Form; Disease Models, Animal; Hippocampus; Male; Motor Activity; Ouabain; Prefrontal Cortex; Rats; Rats, Wistar; Time Factors

2010
Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain.
    Journal of psychiatric research, 2010, Volume: 44, Issue:8

    Topics: Amygdala; Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hippocampus; Lithium Chloride; Male; Motor Activity; Ouabain; Rats; Rats, Wistar; Valproic Acid

2010
Response of sodium pump to ouabain challenge in human glioblastoma cells in culture.
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 2009, Volume: 10, Issue:4 Pt 3

    Topics: Antipsychotic Agents; Bipolar Disorder; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; DNA Primers; DNA, Complementary; Enzyme Inhibitors; Glioblastoma; Humans; Ion Transport; Lithium Carbonate; Neuroglia; Nucleic Acid Amplification Techniques; Ouabain; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Subcellular Fractions

2009
DNA damage after intracerebroventricular injection of ouabain in rats.
    Neuroscience letters, 2010, Feb-26, Volume: 471, Issue:1

    Topics: Animals; Bipolar Disorder; Comet Assay; Disease Models, Animal; DNA; DNA Damage; Hippocampus; Injections, Intraventricular; Male; Micronucleus Tests; Motor Activity; Ouabain; Rats; Rats, Wistar

2010
Evaluation of citrate synthase activity in brain of rats submitted to an animal model of mania induced by ouabain.
    Molecular and cellular biochemistry, 2010, Volume: 341, Issue:1-2

    Topics: Animals; Bipolar Disorder; Brain Chemistry; Citrate (si)-Synthase; Male; Motor Activity; Ouabain; Prefrontal Cortex; Rats; Rats, Wistar

2010
Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania.
    Journal of psychiatric research, 2011, Volume: 45, Issue:2

    Topics: Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Brain; Catalase; Disease Models, Animal; Drug Interactions; Gene Expression Regulation, Enzymologic; Injections, Intraventricular; Lithium Chloride; Male; Ouabain; Protein Carbonylation; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Valproic Acid

2011
Folic acid administration prevents ouabain-induced hyperlocomotion and alterations in oxidative stress markers in the rat brain.
    Bipolar disorders, 2010, Volume: 12, Issue:4

    Topics: Animals; Antimanic Agents; Biomarkers; Bipolar Disorder; Disease Models, Animal; Folic Acid; Hippocampus; Injections, Intraventricular; Lithium Chloride; Male; Motor Activity; Ouabain; Oxidative Stress; Rats; Rats, Wistar

2010
Memantine reduces mania-like symptoms in animal models.
    Psychiatry research, 2011, Aug-15, Volume: 188, Issue:3

    Topics: Action Potentials; Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hippocampus; In Vitro Techniques; Lithium Chloride; Male; Memantine; Ouabain; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Time Factors

2011
Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Aug-07, Volume: 38, Issue:2

    Topics: Animals; Behavior, Animal; Benzene Derivatives; Bipolar Disorder; Brain; Catalase; Glutathione Peroxidase; Glutathione Reductase; Male; Motor Activity; Organoselenium Compounds; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances

2012
Intracerebroventricular administration of ouabain as a model of mania in rats.
    Bipolar disorders, 2003, Volume: 5, Issue:5

    Topics: Animals; Bipolar Disorder; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Enzyme Inhibitors; Injections, Intraventricular; Lithium; Locomotion; Male; Ouabain; Rats; Rats, Sprague-Dawley; Time Factors

2003
Differential response of bipolar and normal control lymphoblastoid cell sodium pump to ethacrynic acid.
    Journal of affective disorders, 2004, Volume: 80, Issue:1

    Topics: Adult; Bipolar Disorder; Blotting, Western; Cell Line; Ethacrynic Acid; Female; Humans; Lymphocytes; Male; Middle Aged; Ouabain; RNA, Messenger; Rubidium Radioisotopes; Sodium-Potassium-Exchanging ATPase; Spectrophotometry, Atomic

2004
Increased cerebrospinal fluid levels of S100B protein in rat model of mania induced by ouabain.
    Life sciences, 2004, Dec-31, Volume: 76, Issue:7

    Topics: Animals; Behavior, Animal; Bipolar Disorder; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Male; Nerve Growth Factors; Ouabain; Rats; Rats, Wistar; S100 Calcium Binding Protein beta Subunit; S100 Proteins

2004
Involvement of Na(+), K(+)-ATPase and endogenous digitalis-like compounds in depressive disorders.
    Biological psychiatry, 2006, Sep-01, Volume: 60, Issue:5

    Topics: Adult; Animals; Behavior, Animal; Bipolar Disorder; Bufanolides; Cardenolides; Depressive Disorder; Disease Models, Animal; Female; Humans; Male; Middle Aged; Mood Disorders; Ouabain; Parietal Lobe; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reference Values; Schizophrenia; Sodium-Potassium-Exchanging ATPase; Synaptosomes

2006
Efficacy of olanzapine and haloperidol in an animal model of mania.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Sep-30, Volume: 30, Issue:7

    Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Bipolar Disorder; Disease Models, Animal; Drug Evaluation; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Haloperidol; Male; Olanzapine; Ouabain; Rats; Rats, Sprague-Dawley

2006
Lithium normalizes elevated intracellular sodium.
    Bipolar disorders, 2007, Volume: 9, Issue:3

    Topics: Antipsychotic Agents; Bipolar Disorder; Cell Line, Tumor; Glioma; Humans; Ion Transport; Lithium Carbonate; Neurons; Ouabain; Sodium; Sodium Channels; Spectrum Analysis

2007
Beta-adrenoceptor binding defects in cell lines from families with manic-depressive disorder.
    Annals of human genetics, 1984, Volume: 48, Issue:3

    Topics: 5'-Nucleotidase; Adolescent; Adult; B-Lymphocytes; Bipolar Disorder; Cell Line; Female; Humans; Male; Nucleotidases; Ouabain; Pedigree; Pindolol; Receptors, Adrenergic, beta

1984
Erythrocyte lithium efflux in bipolar patients and control subjects: the question of reproducibility.
    Psychiatry research, 1984, Volume: 13, Issue:2

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Bipolar Disorder; Cell Membrane; Erythrocytes; Humans; Lithium; Ouabain; Phloretin

1984
Erythrocyte lithium transport in bipolar affective disorders. The effect of membrane transport inhibitors.
    Neuropsychobiology, 1984, Volume: 12, Issue:2-3

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Bipolar Disorder; Cell Membrane Permeability; Erythrocytes; Female; Humans; Lanthanum; Lithium; Male; Ouabain; Phloretin

1984
Red cell ouabain-sensitive Na+-K+-adenosine triphosphatase: a state marker in affective disorder inversely related to plasma cortisol.
    Biological psychiatry, 1982, Volume: 17, Issue:9

    Topics: Adult; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; Bipolar Disorder; Depressive Disorder; Erythrocyte Membrane; Erythrocytes; Female; Genetic Markers; Humans; Hydrocortisone; Lithium; Male; Middle Aged; Ouabain; Sodium-Potassium-Exchanging ATPase

1982
Decreased activity of ouabain-dependent sodium and potassium fluxes in erythrocytes during depression and mania.
    Activitas nervosa superior, 1983, Volume: 25, Issue:1

    Topics: Adult; Biological Transport, Active; Bipolar Disorder; Depression; Erythrocytes; Female; Humans; Male; Ouabain; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase

1983
Erythrocyte lithium transport variables as a marker for manic-depressive disorder.
    Neuropsychobiology, 1983, Volume: 9, Issue:2-3

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4-Chloromercuribenzenesulfonate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Bipolar Disorder; Cell Membrane Permeability; Dimethyl Sulfoxide; Erythrocyte Membrane; Genetic Markers; Humans; Lithium; Ouabain; Phloretin

1983
Erythrocyte cation transport in endogenous depression: clinical and psychophysiological correlates.
    Acta psychiatrica Scandinavica, 1984, Volume: 70, Issue:3

    Topics: Adult; Bipolar Disorder; Depressive Disorder; Erythrocytes; Female; Humans; Male; Middle Aged; Ouabain; Reaction Time; Sex Factors

1984
New approaches to the treatment of manic depressive illness.
    Neuropharmacology, 1980, Volume: 19, Issue:12

    Topics: Ascorbic Acid; Bipolar Disorder; Double-Blind Method; Edetic Acid; Humans; Kinetics; Lymphocytes; Ouabain; Vanadium

1980
Exchange mechanism of tyrosine between plasma and red blood cells in normal subjects and psychiatric patients.
    Neuropsychobiology, 1982, Volume: 8, Issue:4

    Topics: Biological Transport; Bipolar Disorder; Cell Membrane; Cold Temperature; Depressive Disorder; Erythrocytes; Humans; Iodoacetates; Ouabain; Plasma; Psychotic Disorders; Schizophrenia; Tyrosine

1982
Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar illness.
    Medical hypotheses, 1993, Volume: 41, Issue:4

    Topics: Affect; Bipolar Disorder; Digoxin; Erythrocyte Membrane; Humans; Models, Biological; Ouabain; Sodium-Potassium-Exchanging ATPase

1993
An animal model for mania: preliminary results.
    Progress in neuro-psychopharmacology & biological psychiatry, 1995, Volume: 19, Issue:5

    Topics: Animals; Bipolar Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Locomotion; Male; Ouabain; Rats; Rats, Sprague-Dawley; Time Factors

1995
Lithium prevents ouabain-induced behavioral changes. Toward an animal model for manic depression.
    Molecular and chemical neuropathology, 1997, Volume: 31, Issue:1

    Topics: Animals; Antimanic Agents; Bipolar Disorder; Enzyme Inhibitors; Exploratory Behavior; Injections, Intraventricular; Lithium Chloride; Male; Ouabain; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase

1997
Open field is more sensitive than automated activity monitor in documenting ouabain-induced hyperlocomotion in the development of an animal model for bipolar illness.
    Progress in neuro-psychopharmacology & biological psychiatry, 2000, Volume: 24, Issue:3

    Topics: Animals; Bipolar Disorder; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Male; Movement Disorders; Ouabain; Rats; Rats, Sprague-Dawley

2000
A biochemical study of short-cycle manic-depressive psychosis in mental defectives.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 128

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Biological Transport; Biological Transport, Active; Bipolar Disorder; Female; Hematocrit; Humans; Intellectual Disability; Lithium; Ouabain; Periodicity; Potassium; Sodium; Urination

1976
Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects.
    Psychological medicine, 1977, Volume: 7, Issue:2

    Topics: Adenosine Triphosphatases; Adult; Animals; Biological Transport, Active; Bipolar Disorder; Electrolytes; Erythrocyte Membrane; Erythrocytes; Female; Humans; Lithium; Male; Middle Aged; Ouabain; Potassium; Rats; Sodium

1977
Abnormal lithium and sodium transport in erythrocytes of a manic patient and some members of his family.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:8

    Topics: Adolescent; Adult; Biological Transport; Biological Transport, Active; Bipolar Disorder; Child; Erythrocyte Membrane; Erythrocytes; Female; Humans; Lithium; Male; Middle Aged; Ouabain; Phloretin; Sodium

1977
Lithium transport in human red blood cells: genetic and clinical aspects.
    Archives of general psychiatry, 1979, Jul-20, Volume: 36, Issue:8 Spec No

    Topics: Adult; Bicarbonates; Biological Transport; Bipolar Disorder; Diffusion; Erythrocytes; Female; Genotype; Humans; Ion Exchange; Lithium; Male; Molecular Biology; Ouabain; Potassium; Sodium

1979
Altered in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase in patients with manic depressive psychosis.
    Journal of affective disorders, 1991, Volume: 21, Issue:3

    Topics: Bipolar Disorder; Humans; Lithium; Lithium Carbonate; Lymphocytes; Ouabain; Psychiatric Status Rating Scales; Radioligand Assay; Sodium-Potassium-Exchanging ATPase

1991
Erythrocyte membrane cation carrier in depressive illness.
    Psychological medicine, 1973, Volume: 3, Issue:4

    Topics: Adenosine Triphosphatases; Adult; Biological Transport; Bipolar Disorder; Cell Membrane; Depression; Emotions; Erythrocytes; Female; Humans; Middle Aged; Ouabain; Potassium; Psychiatric Status Rating Scales; Sodium

1973
Deficiency of erythrocyte sodium pump activity in bipolar manic-depressive psychosis.
    Life sciences, 1974, Nov-15, Volume: 15, Issue:10

    Topics: Adult; Biological Transport, Active; Bipolar Disorder; Erythrocytes; Female; Humans; Lithium; Male; Middle Aged; Ouabain; Phenothiazines; Sodium; Spectrophotometry, Atomic

1974