osteoprotegerin and Lymphocytosis

osteoprotegerin has been researched along with Lymphocytosis* in 1 studies

Other Studies

1 other study(ies) available for osteoprotegerin and Lymphocytosis

Article	Year
Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. Journal of immunology (Baltimore, Md. : 1950), 2001, Feb-01, Volume: 166, Issue:3 Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg(-/-) mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg(-/-) pro-B cells have enhanced proliferation to IL-7, and in opg(-/-) spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg(-/-) bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg(-/-) mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses. Topics: Animals; B-Lymphocyte Subsets; B-Lymphocytes; Bone and Bones; Cell Differentiation; Dendritic Cells; Gene Targeting; Glycoproteins; Hematopoiesis; Immunoglobulin Class Switching; Immunoglobulin D; Immunoglobulin Isotypes; Immunoglobulin M; Lymphocyte Activation; Lymphocyte Count; Lymphocytosis; Mice; Mice, Inbred Strains; Mice, Knockout; Osteoporosis; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; T-Lymphocytes	2001

Article

Year

Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.

Journal of immunology (Baltimore, Md. : 1950), 2001, Feb-01, Volume: 166, Issue:3

Osteoprotegerin (OPG) is a CD40-regulated gene in B cells and dendritic cells (DCs). We investigated the role of OPG in the immune system by generating opg(-/-) mice. Like its role as a regulator of bone metabolism, OPG also influences processes in the immune system, notably in B cell development. Ex vivo, opg(-/-) pro-B cells have enhanced proliferation to IL-7, and in opg(-/-) spleen, there is an accumulation of type 1 transitional B cells. Furthermore, opg(-/-) bone marrow-derived DCs are more effective in stimulating allogeneic T cells than control DCs. When challenged with a T-dependent Ag, opg(-/-) mice had a compromised ability to sustain an IgG3 Ag-specific response. Thus, in the immune system, OPG regulates B cell maturation and development of efficient Ab responses.

Topics: Animals; B-Lymphocyte Subsets; B-Lymphocytes; Bone and Bones; Cell Differentiation; Dendritic Cells; Gene Targeting; Glycoproteins; Hematopoiesis; Immunoglobulin Class Switching; Immunoglobulin D; Immunoglobulin Isotypes; Immunoglobulin M; Lymphocyte Activation; Lymphocyte Count; Lymphocytosis; Mice; Mice, Inbred Strains; Mice, Knockout; Osteoporosis; Osteoprotegerin; Receptors, Cytoplasmic and Nuclear; Receptors, Tumor Necrosis Factor; T-Lymphocytes

2001