osteoprotegerin and Jaw--Edentulous--Partially

This 3-year prospective randomized controlled trial compared the clinical, microbiological and biochemical outcome of minimally (Turned, Tur) and moderately rough (TiUnite(®) , TiU) implant surfaces in a split-mouth design.. The study population included 14 subjects: nine fully edentulous and five partially edentulous subjects with a history of periodontitis. Implants (n = 78, 39 Tur and 39 TiU) were installed randomly in each patient. Peri-implant clinical parameters and intra-oral radiographs were recorded after 3 years of loading. Subgingival plaque and peri-implant crevicular fluid samples were collected and analysed using culture and quantitative polymerase chain reaction for the biofilm, and enzyme-linked immunosorbent assay for the concentration of osteoprotegerin and receptor activator of nuclear factor kappa-B ligand, respectively.. No statistically significant differences in clinical, microbiological and biochemical parameters could be observed when comparing the Tur and TiU implant surfaces.. After 3 years of loading, in periodontitis susceptible patients, the moderately rough, TiU implants demonstrated a similar clinical outcome compared with the smoother, turned implants. Longer follow-up and studies using different implant types are needed to confirm the statement that minimally and moderately rough implant surfaces perform similar, both from a clinical and from a microbiological point of view.

Topics: Aged; Alveolar Bone Loss; Analysis of Variance; Chronic Periodontitis; Coated Materials, Biocompatible; Dental Implants; Dental Prosthesis Design; Dental Prosthesis, Implant-Supported; Female; Follow-Up Studies; Gingival Crevicular Fluid; Gingival Recession; Humans; Jaw, Edentulous; Jaw, Edentulous, Partially; Male; Middle Aged; Osteoprotegerin; Oxides; Periodontal Index; Pilot Projects; Prospective Studies; RANK Ligand; Surface Properties