orphenadrine has been researched along with Neuroleptic Malignant Syndrome in 2 studies
Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Orphenadrine is an antimuscarinic agent mainly used for the treatment of parkinsonism and to alleviate the neuroleptic syndrome induced by antipsychotic drugs." | 1.35 | Determination of orphenadrine plasma levels using HPLC with diode array detection and a novel solid-phase extraction procedure in psychiatric patients. ( Franchini, L; Petio, C; Raggi, MA; Saracino, MA; Vitali, M, 2009) |
| "A case of recurrent neuroleptic malignant syndrome (NMS) occurring in a 29-year-old man with mild mental handicap and a superadded psychotic disorder is described." | 1.28 | Recurrent neuroleptic malignant syndrome in a man with mild mental handicap. ( Bambrick, M; Wilson, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saracino, MA | 1 |
| Petio, C | 1 |
| Vitali, M | 1 |
| Franchini, L | 1 |
| Raggi, MA | 1 |
| Bambrick, M | 1 |
| Wilson, D | 1 |
2 other studies available for orphenadrine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Determination of orphenadrine plasma levels using HPLC with diode array detection and a novel solid-phase extraction procedure in psychiatric patients.
Topics: Antipsychotic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug M | 2009 |
Recurrent neuroleptic malignant syndrome in a man with mild mental handicap.
Topics: Adult; Antipsychotic Agents; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1992 |