orphenadrine has been researched along with Muscle Spasticity in 5 studies
Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "One patient with severe spastic hypertonia leading to triple flexion when the limb was manipulated did not gain any relief with orphenadrine." | 2.68 | Reduction of spastic hypertonia in patients with spinal cord injury: a double-blind comparison of intravenous orphenadrine citrate and placebo. ( Buonocore, M; Casale, R; Glynn, CJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Steinbrecher, W | 1 |
| McGuinness, BW | 1 |
| Casale, R | 1 |
| Glynn, CJ | 1 |
| Buonocore, M | 1 |
| Hartmann-von Monakow, K | 1 |
| Lenman, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Response of Nuberol Forte® for the Pain Management in Musculoskeletal Disorders in Routine Pakistani Practice[NCT04765787] | 399 participants (Actual) | Observational | 2020-11-25 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for orphenadrine and Muscle Spasticity
| Article | Year |
|---|---|
A double-blind comparison in general practice of a combination tablet containing orphenadrine citrate and paracetamol ('Norgesic') with paracetamol alone.
Topics: Acetaminophen; Adolescent; Adult; Aged; Back Pain; Bone Diseases; Double-Blind Method; Drug Combinat | 1983 |
Reduction of spastic hypertonia in patients with spinal cord injury: a double-blind comparison of intravenous orphenadrine citrate and placebo.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Injections, Intravenous; Leg; Male; | 1995 |
3 other studies available for orphenadrine and Muscle Spasticity
| Article | Year |
|---|---|
[Myotonolysis by means of orphenadrine citrate. Clinical and electromyographic studies in cerebral and spinal spasticity].
Topics: Action Potentials; Automatism; Central Nervous System Diseases; Citrates; Electromyography; Humans; | 1966 |
[Therapy of spastic syndromes].
Topics: Carisoprodol; Chlordiazepoxide; Chlormezanone; Chlorzoxazone; Curare; Diazepam; Guaifenesin; Humans; | 1969 |
The use of drugs in the treatment of spasticity.
Topics: Chlordiazepoxide; Curare; Diazepam; Electromyography; Humans; Mephenesin; Muscle Spasticity; Orphena | 1970 |