orphenadrine and Low Back Ache
orphenadrine has been researched along with Low Back Ache in 2 studies
Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo." | 9.27 | A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018) |
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo." | 5.27 | A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018) |
Research
Studies (2)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (50.00) | 24.3611 |
2020's | 1 (50.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Abril, L | 1 |
Zamora, C | 1 |
Cordero, M | 1 |
Williams, AR | 1 |
Friedman, BW | 2 |
Cisewski, D | 1 |
Irizarry, E | 1 |
Davitt, M | 1 |
Solorzano, C | 1 |
Nassery, A | 1 |
Pearlman, S | 1 |
White, D | 1 |
Gallagher, EJ | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Methocarbamol and Orphenadrine for Acute, Non-traumatic, Non-radicular Low Back Pain: A Randomized, Placebo Controlled, 3-armed Study[NCT02665286] | Phase 4 | 240 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Cases of Moderate or Severe LBP
Participants with moderate to severe low back pain after treatment as report on the following ordinal scale: severe, moderate, mild, or none (NCT02665286)
Timeframe: 1 week
Intervention | Participants (Count of Participants) |
---|---|
Placebo | 34 |
Orphenadrine | 26 |
Methocarbamol | 31 |
Functional Impairment as Measured on the Roland Morris Disability Questionnaire
"Change in Roland Morris Disability Questionnaire between baseline and 1 week.~The low back pain functional disability scale is the RMDQ. The RMDQ is a 24-item low back pain functional scale recommended for use in low back pain research.Higher scores signify greater low back-related functional impairment.0= no functional impairment, 24= severe functional impairment." (NCT02665286)
Timeframe: 1 week
Intervention | units on a scale (Mean) |
---|---|
Placebo | 10.9 |
Orphenadrine | 9.4 |
Methocarbamol | 8.1 |
Medications--Patient Self Report of Medication Use
Participants still using medication such as analgesics for LBP after treatment (NCT02665286)
Timeframe: 1 week
Intervention | Participants (Count of Participants) |
---|---|
Placebo | 42 |
Orphenadrine | 40 |
Methocarbamol | 50 |
Patient Satisfaction With Treatment
The number of participants with affirmative response to the following question: Do you want the same medication combination during a subsequent episode of LBP. This is a patient-centered outcome that allows each individual to determine the desirability of the intervention. (NCT02665286)
Timeframe: 1 week
Intervention | Participants (Count of Participants) |
---|---|
Placebo | 51 |
Orphenadrine | 53 |
Methocarbamol | 51 |
Trials
1 trial available for orphenadrine and Low Back Ache
Article | Year |
---|---|
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.
Topics: Acute Pain; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela | 2018 |
Other Studies
1 other study available for orphenadrine and Low Back Ache
Article | Year |
---|---|
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Diazepam; Humans; Low Back Pain; Meth | 2022 |