Page last updated: 2024-11-02

orphenadrine and Low Back Ache

orphenadrine has been researched along with Low Back Ache in 2 studies

Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

Research Excerpts

ExcerptRelevanceReference
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo."9.27A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018)
"Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo."5.27A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's1 (50.00)2.80

Authors

AuthorsStudies
Abril, L1
Zamora, C1
Cordero, M1
Williams, AR1
Friedman, BW2
Cisewski, D1
Irizarry, E1
Davitt, M1
Solorzano, C1
Nassery, A1
Pearlman, S1
White, D1
Gallagher, EJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Methocarbamol and Orphenadrine for Acute, Non-traumatic, Non-radicular Low Back Pain: A Randomized, Placebo Controlled, 3-armed Study[NCT02665286]Phase 4240 participants (Actual)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cases of Moderate or Severe LBP

Participants with moderate to severe low back pain after treatment as report on the following ordinal scale: severe, moderate, mild, or none (NCT02665286)
Timeframe: 1 week

InterventionParticipants (Count of Participants)
Placebo34
Orphenadrine26
Methocarbamol31

Functional Impairment as Measured on the Roland Morris Disability Questionnaire

"Change in Roland Morris Disability Questionnaire between baseline and 1 week.~The low back pain functional disability scale is the RMDQ. The RMDQ is a 24-item low back pain functional scale recommended for use in low back pain research.Higher scores signify greater low back-related functional impairment.0= no functional impairment, 24= severe functional impairment." (NCT02665286)
Timeframe: 1 week

Interventionunits on a scale (Mean)
Placebo10.9
Orphenadrine9.4
Methocarbamol8.1

Medications--Patient Self Report of Medication Use

Participants still using medication such as analgesics for LBP after treatment (NCT02665286)
Timeframe: 1 week

InterventionParticipants (Count of Participants)
Placebo42
Orphenadrine40
Methocarbamol50

Patient Satisfaction With Treatment

The number of participants with affirmative response to the following question: Do you want the same medication combination during a subsequent episode of LBP. This is a patient-centered outcome that allows each individual to determine the desirability of the intervention. (NCT02665286)
Timeframe: 1 week

InterventionParticipants (Count of Participants)
Placebo51
Orphenadrine53
Methocarbamol51

Trials

1 trial available for orphenadrine and Low Back Ache

ArticleYear
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.
    Annals of emergency medicine, 2018, Volume: 71, Issue:3

    Topics: Acute Pain; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela

2018

Other Studies

1 other study available for orphenadrine and Low Back Ache

ArticleYear
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
    The Journal of emergency medicine, 2022, Volume: 62, Issue:4

    Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Diazepam; Humans; Low Back Pain; Meth

2022
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