Compounds > orphenadrine
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orphenadrine and Idiopathic Parkinson Disease

orphenadrine has been researched along with Idiopathic Parkinson Disease in 48 studies

Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

Research Excerpts

ExcerptRelevanceReference
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."7.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)
"In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy."3.65Visual hallucinations and delirium during treatment with amantadine (Symmetrel). ( Postma, JU; Van Tilburg, W, 1975)
" Hence we would advise that if for any reason anticholinergic drugs are to be withdrawn in patients receiving a stable dosage of levodopa this must be done slowly."2.64Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs. ( Hughes, RC; Polgar, JG; Walton, JN; Weightman, D, 1971)
"The treatment of Parkinson's disease today is complex, time-consuming, but rewarding."2.35Advances in the management of parkinson's disease. ( Marsden, CD, 1976)
"This outnumbered sales to patients with Parkinson's disease by >20 to 1."1.35The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study. ( Bramness, JG; Gjerden, P; Slørdal, L, 2009)
"The STN rest electrical activity in Parkinson's disease, however, is still unclear."1.32Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease. ( Bianchi, AM; Foffani, G; Locatelli, M; Moxon, KA; Pellegrini, M; Pesenti, A; Priori, A; Tamma, F; Villani, RM, 2004)
"The effect of chronic intake of the anticholinergic drug orphenadrine on the bioavailability of levodopa was studied in six patients with Parkinson's disease."1.28Combined levodopa-anticholinergic therapy in the treatment of Parkinson's disease. Effect on levodopa bioavailability. ( Albani, F; Baruzzi, A; Contin, M; Martinelli, P; Procaccianti, G; Riva, R, 1991)
" In the sixth year, it appeared necessary to increase the dosage in the first three groups."1.27Low-dosage treatment in de novo patients with Parkinson's disease: a prospective study. ( van der Drift, JH, 1987)

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-199043 (89.58)18.7374
1990's2 (4.17)18.2507
2000's3 (6.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gjerden, P2
Bramness, JG2
Slørdal, L2
KOSTER, S1
DOSHAY, LJ1
CONSTABLE, K1
MASCIOCCHI, A1
SFRONDINI, E1
ROSENFELD, S1
NAYAMPALLI, SS1
GOLDNER, MG1
RUDRAUF, J1
CHALLOU, C1
MEURICE, E1
ONUAGULUCHI, G1
BAUER, H1
GERSTENBRAND, F1
PATEISKY, K1
GILLINGHAM, FJ1
KALYANARAMAN, S1
STRANG, RR4
ERNSTING, W1
MUELLER, TH1
ROBINSON, LR1
DICK, TH1
Priori, A1
Foffani, G1
Pesenti, A1
Tamma, F1
Bianchi, AM1
Pellegrini, M1
Locatelli, M1
Moxon, KA1
Villani, RM1
Wheatley, D1
Van Spaendonck, KP1
Berger, HJ1
Horstink, MW1
Buytenhuijs, EL1
Cools, AR1
Korczyn, AD1
Goldberg, GJ1
Dainow, II1
Postma, JU1
Van Tilburg, W1
Gerlach, J1
Rasmussen, PT1
Hansen, L1
Kristjansen, P1
Marsden, CD1
Parkenberg, H1
Contin, M1
Riva, R1
Martinelli, P1
Procaccianti, G1
Albani, F1
Baruzzi, A1
Mugglestone, CJ1
Bassi, S1
Albizzati, MG1
Calloni, E1
Sbacchi, M1
Frattola, L1
van der Drift, JH1
Walls, TJ1
Dick, DJ1
Fletcher, J1
Zheng, JH1
Birket-Smith, E1
Naylor, RJ1
Costall, B1
Mindham, RH1
Gaind, R1
Anstee, BH1
Rimmer, L1
Broe, GA1
Caird, FI1
Whyte, RK1
Hunter, KR1
Laurence, DR1
Stern, GM1
Armitage, P1
Ban, T1
Hojo, M1
Stern, G1
Boman, K1
Meurman, T1
Hughes, RC1
Polgar, JG1
Weightman, D1
Walton, JN1
Aquilonius, SM1
Tiselius, P1
Ekdawi, MY1
Fowke, R1

Reviews

1 review available for orphenadrine and Idiopathic Parkinson Disease

ArticleYear
Advances in the management of parkinson's disease.
    Scottish medical journal, 1976, Volume: 21, Issue:3

    Topics: Amantadine; Anesthesia; Humans; Levodopa; Orphenadrine; Parasympatholytics; Parkinson Disease; Socia

1976

Trials

7 trials available for orphenadrine and Idiopathic Parkinson Disease

ArticleYear
Extrapyramidal effects of neuroleptics.
    Journal of neurology, neurosurgery, and psychiatry, 1976, Volume: 39, Issue:9

    Topics: Adult; Age Factors; Antipsychotic Agents; Clinical Trials as Topic; Dyskinesia, Drug-Induced; Extrap

1976
Antiparkinsonian agents and long-term neuroleptic treatment. Effect of G 31.406, orphenadrine, and placebo on parkinsonism, schizophrenic symptoms, depression and anxiety.
    Acta psychiatrica Scandinavica, 1977, Volume: 55, Issue:4

    Topics: Administration, Oral; Adult; Aged; Antiparkinson Agents; Anxiety; Clinical Trials as Topic; Depressi

1977
Experiences with cogentin in the treatment of Parkinsonism. A one-year controlled study of 94 patients.
    Acta neurologica Scandinavica, 1966, Volume: 41, Issue:4

    Topics: Adult; Aged; Clinical Trials as Topic; Depression, Chemical; Female; Histamine H1 Antagonists; Human

1966
Comparison of amantadine, orphenadrine, and placebo in the control of phenothiazine-induced Parkinsonism.
    Psychological medicine, 1972, Volume: 2, Issue:4

    Topics: Affect; Amantadine; Basal Ganglia Diseases; Clinical Trials as Topic; Evaluation Studies as Topic; F

1972
Levodopa and orphenadrine hydrochloride in Parkinsonism.
    European journal of clinical pharmacology, 1971, Volume: 4, Issue:1

    Topics: Administration, Oral; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Evaluation Studies as

1971
Orphenadrine ("Disipal") in the treatment of Parkinsonism: a two-year study of 150 patients.
    The Medical journal of Australia, 1965, Sep-11, Volume: 2, Issue:11

    Topics: Adult; Aged; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Male; Middle Aged; Orphenadri

1965
Levodopa in Parkinsonism: the effects of withdrawal of anticholinergic drugs.
    British medical journal, 1971, May-29, Volume: 2, Issue:5760

    Topics: Dihydroxyphenylalanine; Drug Synergism; Drug Tolerance; Female; Humans; Male; Methods; Neurologic Ma

1971

Other Studies

40 other studies available for orphenadrine and Idiopathic Parkinson Disease

ArticleYear
The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study.
    British journal of clinical pharmacology, 2009, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Cholinergic Antagoni

2009
The use of antipsychotic and anticholinergic antiparkinson drugs in Norway after the withdrawal of orphenadrine.
    British journal of clinical pharmacology, 2009, Volume: 68, Issue:2

    Topics: Antipsychotic Agents; Cholinergic Antagonists; Drug Administration Schedule; Female; Humans; Male; N

2009
[Experience with disipal (BS 5930) in paralysis agitans].
    Geneeskundige gids, 1955, Jul-21, Volume: 33, Issue:15

    Topics: Diphenhydramine; Orphenadrine; Parkinson Disease

1955
Treatment of paralysis agitans with orphenadrine (disipal) hydrochloride; results in one hundred seventy-six cases.
    Journal of the American Medical Association, 1957, Apr-13, Volume: 163, Issue:15

    Topics: Diphenhydramine; Orphenadrine; Parkinson Disease; Salts

1957
[Disipal in the treatment of post-encephalitic parkinsonism].
    Rassegna di neuropsichiatria e scienze affini, 1958, Volume: 12, Issue:3-4

    Topics: Diphenhydramine; Encephalitis; Humans; Orphenadrine; Parkinson Disease; Parkinson Disease, Postencep

1958
An evaluation of orphenadrine hydrochloride (disipal).
    Journal of the American Geriatrics Society, 1959, Volume: 7, Issue:6

    Topics: Aged; Diphenhydramine; Humans; Orphenadrine; Parkinson Disease

1959
[Clinical study on the combined action of orphenadrine and thioproperazine: correction of neuroleptic impregnation and therapeutic synergism].
    Acta neurologica et psychiatrica Belgica, 1961, Volume: 61

    Topics: Antipsychotic Agents; Drug Interactions; Orphenadrine; Parasympatholytics; Parkinson Disease; Phenot

1961
[Disipal and the correction of parkinsonism induced by neuroleptics. (A critical review)].
    Acta neurologica et psychiatrica Belgica, 1961, Volume: 61

    Topics: Antipsychotic Agents; Orphenadrine; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders; P

1961
Investigations into the so-called reserpine Parkinsonoid in chronic schizophrenics and its treatment with orphenadrine (disipal).
    Folia psychiatrica, neurologica et neurochirurgica Neerlandica, 1959, Volume: 62

    Topics: Anticonvulsants; Humans; Orphenadrine; Parkinson Disease; Reserpine; Schizophrenia

1959
Assessment of drug therapy in Parkinsonism.
    British medical journal, 1963, Feb-16, Volume: 1, Issue:5328

    Topics: Humans; Nortropanes; Orphenadrine; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders

1963
[TREATMENT OF SEVERE PARKINSON'S SYNDROME WITH ORPHENADRINE WITH SPECIAL REFERENCE TO MENTAL ACTIVITY].
    Medizinische Klinik, 1963, Sep-13, Volume: 58

    Topics: Humans; Mental Processes; Orphenadrine; Parkinson Disease; Parkinsonian Disorders

1963
[CONTRIBUTION TO THE THERAPY AND REHABILITATION OF PARKINSON'S SYNDROME].
    Wiener Zeitschrift fur Nervenheilkunde und deren Grenzgebiete, 1963, Volume: 21

    Topics: Histamine H1 Antagonists; Neurosurgery; Orphenadrine; Parasympatholytics; Parkinson Disease; Parkins

1963
PARKINSON'S DISEASE.
    Physiotherapy, 1963, Dec-10, Volume: 49

    Topics: Amitriptyline; Dextroamphetamine; Humans; Imipramine; Muscle Relaxants, Central; Neurosurgery; Orphe

1963
ORPHENADRINE IN THE TREATMENT OF PARKINSON'S DISEASE.
    Current medicine and drugs, 1964, Volume: 5, Issue:1

    Topics: Biomedical Research; Geriatrics; Orphenadrine; Parkinson Disease; Parkinsonian Disorders; Pharmacolo

1964
[DISIPAL IN THE TREATMENT OF PARKINSON'S DISEASE. A STUDY CONCERNING 80 PATIENTS IN A 6-MONTH PERIOD].
    Svenska lakartidningen, 1964, Sep-16, Volume: 61

    Topics: Drug Therapy; Orphenadrine; Parkinson Disease; Parkinsonian Disorders; Research

1964
[The treatment of the Parkinson syndrome with disipal (BS 5930)].
    Nederlands tijdschrift voor geneeskunde, 1955, Apr-09, Volume: 99, Issue:15

    Topics: Diphenhydramine; Orphenadrine; Parkinson Disease

1955
[On the medicinal treatment of Parkinson's syndrome. Clinical experiences with disipal].
    Wiener medizinische Wochenschrift (1946), 1960, Apr-23, Volume: 110

    Topics: Humans; Orphenadrine; Parasympatholytics; Parkinson Disease

1960
A clinical assessment of orphenadrine (disipal) in the treatment of Parkinsonism.
    The Ulster medical journal, 1960, Jun-01, Volume: 29

    Topics: Humans; Orphenadrine; Parasympatholytics; Parkinson Disease; Parkinsonian Disorders

1960
Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease.
    Experimental neurology, 2004, Volume: 189, Issue:2

    Topics: Action Potentials; Adult; Aged; Alpha Rhythm; Antiparkinson Agents; Apomorphine; Beta Rhythm; Biolog

2004
Combined treatment in Parkinson's disease.
    The Practitioner, 1983, Volume: 227, Issue:1377

    Topics: Aged; Amantadine; Antiparkinson Agents; Drug Therapy, Combination; Female; Humans; Male; Middle Aged

1983
Impaired cognitive shifting in parkinsonian patients on anticholinergic therapy.
    Neuropsychologia, 1993, Volume: 31, Issue:4

    Topics: Aged; Cognition; Female; Humans; Male; Middle Aged; Orphenadrine; Parasympatholytics; Parkinson Dise

1993
Deaths after overdoses of orphenadrine.
    Lancet (London, England), 1977, Sep-24, Volume: 2, Issue:8039

    Topics: Drug Interactions; Humans; Orphenadrine; Parkinson Disease; Phenothiazines

1977
Visual hallucinations and delirium during treatment with amantadine (Symmetrel).
    Journal of the American Geriatrics Society, 1975, Volume: 23, Issue:5

    Topics: Aged; Amantadine; Benztropine; Biperiden; Delirium; Drug Eruptions; Female; Hallucinations; Humans;

1975
[Treatment of parkinsonism].
    Ugeskrift for laeger, 1976, Apr-26, Volume: 138, Issue:18

    Topics: Amantadine; Benztropine; Biperiden; Humans; Levodopa; Orphenadrine; Parkinson Disease; Procyclidine;

1976
Combined levodopa-anticholinergic therapy in the treatment of Parkinson's disease. Effect on levodopa bioavailability.
    Clinical neuropharmacology, 1991, Volume: 14, Issue:2

    Topics: Adult; Aged; Biological Availability; Drug Administration Schedule; Drug Interactions; Drug Therapy,

1991
Dangers of orphenadrine in psychiatric patients.
    Lancet (London, England), 1985, Sep-14, Volume: 2, Issue:8455

    Topics: Humans; Orphenadrine; Parkinson Disease; Risk; Substance-Related Disorders

1985
Treatment of Parkinson's disease with orphenadrine alone and in combination with L-dopa.
    The British journal of clinical practice, 1986, Volume: 40, Issue:7

    Topics: Aged; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Orphenadrine; Parkinso

1986
Low-dosage treatment in de novo patients with Parkinson's disease: a prospective study.
    Advances in neurology, 1987, Volume: 45

    Topics: Aged; Bromocriptine; Carbidopa; Disability Evaluation; Dose-Response Relationship, Drug; Drug Combin

1987
Problems with inactivation of drugs used in Parkinson's disease.
    British medical journal (Clinical research ed.), 1985, Feb-09, Volume: 290, Issue:6466

    Topics: Aged; Bromocriptine; Drug Stability; Female; Humans; Orphenadrine; Parkinson Disease; Suspensions

1985
[Therapeutic effect of disipal in Parkinson's disease].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:4

    Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Orphenadrine; Parkinson Disease

1985
Abnormal involuntary movements induced by anticholinergic therapy.
    Acta neurologica Scandinavica, 1974, Volume: 50, Issue:6

    Topics: Aged; Biperiden; Dibenzazepines; Female; Humans; Mastication; Middle Aged; Movement Disorders; Orphe

1974
The relationship between the inhibition of dopamine uptake and the enhancement of amphetamine stereotypy.
    Life sciences. Pt. 1: Physiology and pharmacology, 1971, Aug-15, Volume: 10, Issue:16

    Topics: Amantadine; Amphetamine; Animals; Behavior, Animal; Chlorpheniramine; Dopamine; Dopamine Antagonists

1971
Levodopa for parkinsonism in elderly and demented patients.
    The Medical journal of Australia, 1973, Mar-31, Volume: 1, Issue:13

    Topics: Activities of Daily Living; Aged; Cardiovascular Diseases; Dementia; Dihydroxyphenylalanine; Drug Sy

1973
A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activities.
    Psychopharmacologia, 1971, Volume: 19, Issue:1

    Topics: Animals; Diphenhydramine; Drug Antagonism; Electroencephalography; Male; Muscle Tonus; Muscles; Orph

1971
Parkinsonism and dopa.
    The New Zealand medical journal, 1969, Volume: 69, Issue:444

    Topics: Dihydroxyphenylalanine; Humans; New Zealand; Orphenadrine; Parkinson Disease; Parkinson Disease, Pos

1969
Parkinsonism.
    British medical journal, 1969, Nov-29, Volume: 4, Issue:5682

    Topics: Agranulocytosis; Dihydroxyphenylalanine; Humans; Middle Aged; Nausea; Orphenadrine; Parasympatholyti

1969
Investigations on the effect of some drugs on the Parkinsonian rigidity.
    Acta neurologica Scandinavica, 1970, Volume: 46, Issue:1

    Topics: Adult; Atropine; Biperiden; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Contr

1970
Measurement of rigidity and tremor in Parkinson's disease.
    Acta neurologica Scandinavica, 1969, Volume: 45, Issue:3

    Topics: Elasticity; Humans; Joint Diseases; Joints; Movement; Orphenadrine; Oscillometry; Parasympatholytics

1969
Antiparkinsonism drugs.
    The Medical letter on drugs and therapeutics, 1965, Mar-12, Volume: 7, Issue:6

    Topics: Antidepressive Agents; Atropine; Diphenhydramine; Humans; Orphenadrine; Parasympatholytics; Parkinso

1965
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism.
    The British journal of psychiatry : the journal of mental science, 1966, Volume: 112, Issue:487

    Topics: Adolescent; Adult; Chlorpromazine; Haloperidol; Humans; Middle Aged; Orphenadrine; Parasympatholytic

1966