Page last updated: 2024-11-02

orphenadrine and Cramp

orphenadrine has been researched along with Cramp in 14 studies

Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.

Research Excerpts

ExcerptRelevanceReference
"Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo."9.34Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study. ( Abd-Elsalam, S; Alkhalawany, W; Badawi, R; Ebrahim, S; Elfert, A; Elkadeem, M; Hawash, N; Soliman, S, 2020)
"Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms."8.84Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008)
"Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo."5.34Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study. ( Abd-Elsalam, S; Alkhalawany, W; Badawi, R; Ebrahim, S; Elfert, A; Elkadeem, M; Hawash, N; Soliman, S, 2020)
"Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms."4.84Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-199011 (78.57)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's0 (0.00)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Abd-Elsalam, S1
Ebrahim, S1
Soliman, S1
Alkhalawany, W1
Elfert, A1
Hawash, N1
Elkadeem, M1
Badawi, R1
FRIEDMAN, M1
SWEENEY, RE1
SLOANE, HS1
MOODY, WM1
SMITH, CM1
Guay, DR1
Valtonen, EJ1
Mathey, HG1
Hartmann-von Monakow, K1
Guidotti, FP1
Dilluvio, V1
Popkin, RJ1
Whittaker, VB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomized Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis[NCT02423395]Phase 3100 participants (Anticipated)Interventional2015-01-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for orphenadrine and Cramp

ArticleYear
Are there alternatives to the use of quinine to treat nocturnal leg cramps?
    The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2008, Volume: 23, Issue:2

    Topics: Amines; Calcium Channel Blockers; Carisoprodol; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino

2008

Trials

4 trials available for orphenadrine and Cramp

ArticleYear
Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study: Erratum.
    European journal of gastroenterology & hepatology, 2024, Jan-01, Volume: 36, Issue:1

    Topics: Humans; Liver Cirrhosis; Muscle Cramp; Orphenadrine

2024
Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study.
    European journal of gastroenterology & hepatology, 2020, Volume: 32, Issue:8

    Topics: Humans; Liver Cirrhosis; Muscle Cramp; Orphenadrine; Pain; Treatment Outcome

2020
A controlled clinical trial of chlormezanone, orphenadrine, orphenadrine/paracetamol and placebo in the treatment of painful skeletal muscle spasms.
    Annals of clinical research, 1975, Volume: 7, Issue:2

    Topics: Acetaminophen; Chlormezanone; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination;

1975
Oral treatment of skeletal muscle spasm with fluphenazine alone and combined with orphenadrine.
    Current therapeutic research, clinical and experimental, 1965, Volume: 7, Issue:11

    Topics: Adolescent; Adult; Clinical Trials as Topic; Female; Fluphenazine; Humans; Male; Middle Aged; Muscle

1965

Other Studies

9 other studies available for orphenadrine and Cramp

ArticleYear
Pareneral orphenadrine citrate in skeletal muscle spasm.
    Southwestern medicine, 1963, Volume: 44

    Topics: Databases, Genetic; Humans; Muscle Cramp; Muscle, Skeletal; Musculoskeletal System; Nervous System D

1963
Oral treatment of skeletal muscle spasm: a double-blind clinical study.
    Current therapeutic research, clinical and experimental, 1963, Volume: 5

    Topics: Administration, Oral; Double-Blind Method; Fluphenazine; Humans; Muscle Cramp; Muscle, Skeletal; Mus

1963
EXPERIENCES WITH A MUSCLE RELAXANT-ANALGESIC COMBINATION IN GENERAL PRACTICE.
    The Practitioner, 1963, Volume: 191

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Family Practice; General Practice

1963
EFFECTIVE OFFICE MANAGEMENT OF PAINFUL TRAUMATIC MUSCLE INJURIES.
    The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society, 1964, Volume: 116

    Topics: Biomedical Research; Drug Therapy; Humans; Muscle Cramp; Muscular Diseases; Office Management; Orphe

1964
RELAXATION OF DECEREBRATE RIGIDITY BY ORPHENADRINE.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1964, Volume: 116

    Topics: Cats; Decerebrate State; Muscle Cramp; Nervous System Physiological Phenomena; Orphenadrine; Pharmac

1964
[Therapeutic experiences with orphenadrine citrate Norflex].
    Die Medizinische Welt, 1967, Sep-30, Volume: 39

    Topics: Citrates; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Cramp; Muscles; Orphena

1967
[Therapy of spastic syndromes].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Carisoprodol; Chlordiazepoxide; Chlormezanone; Chlorzoxazone; Curare; Diazepam; Guaifenesin; Humans;

1969
Orphenadrine citrate (Norflex) for the treatment of "restless legs" and related syndromes.
    Journal of the American Geriatrics Society, 1971, Volume: 19, Issue:1

    Topics: Adult; Aged; Female; Humans; Leg; Male; Middle Aged; Muscle Cramp; Orphenadrine; Paresthesia

1971
The effect of orphenadrine citrate by injection in skeletal muscle spasm using an electromyographic examination technique.
    The British journal of clinical practice, 1969, Volume: 23, Issue:3

    Topics: Electromyography; Humans; Injections, Intravenous; Muscle Cramp; Orphenadrine

1969