orphenadrine has been researched along with Cramp in 14 studies
Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo." | 9.34 | Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study. ( Abd-Elsalam, S; Alkhalawany, W; Badawi, R; Ebrahim, S; Elfert, A; Elkadeem, M; Hawash, N; Soliman, S, 2020) |
| "Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms." | 8.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| "Frequency, duration of muscle cramps, and pain score improved significantly after 1 month of orphenadrine therapy in comparison to placebo." | 5.34 | Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study. ( Abd-Elsalam, S; Alkhalawany, W; Badawi, R; Ebrahim, S; Elfert, A; Elkadeem, M; Hawash, N; Soliman, S, 2020) |
| "Selection and extraction: a MEDLINE/PubMed, English-language literature search from 1966 to the present using quinine, leg cramps, vitamin E, verapamil, muscle relaxants, gabapentin as search terms." | 4.84 | Are there alternatives to the use of quinine to treat nocturnal leg cramps? ( Guay, DR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abd-Elsalam, S | 1 |
| Ebrahim, S | 1 |
| Soliman, S | 1 |
| Alkhalawany, W | 1 |
| Elfert, A | 1 |
| Hawash, N | 1 |
| Elkadeem, M | 1 |
| Badawi, R | 1 |
| FRIEDMAN, M | 1 |
| SWEENEY, RE | 1 |
| SLOANE, HS | 1 |
| MOODY, WM | 1 |
| SMITH, CM | 1 |
| Guay, DR | 1 |
| Valtonen, EJ | 1 |
| Mathey, HG | 1 |
| Hartmann-von Monakow, K | 1 |
| Guidotti, FP | 1 |
| Dilluvio, V | 1 |
| Popkin, RJ | 1 |
| Whittaker, VB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis[NCT02423395] | Phase 3 | 100 participants (Anticipated) | Interventional | 2015-01-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for orphenadrine and Cramp
| Article | Year |
|---|---|
Are there alternatives to the use of quinine to treat nocturnal leg cramps?
Topics: Amines; Calcium Channel Blockers; Carisoprodol; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Amino | 2008 |
4 trials available for orphenadrine and Cramp
| Article | Year |
|---|---|
Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study: Erratum.
Topics: Humans; Liver Cirrhosis; Muscle Cramp; Orphenadrine | 2024 |
Orphenadrine in treatment of muscle cramps in cirrhotic patients: a randomized study.
Topics: Humans; Liver Cirrhosis; Muscle Cramp; Orphenadrine; Pain; Treatment Outcome | 2020 |
A controlled clinical trial of chlormezanone, orphenadrine, orphenadrine/paracetamol and placebo in the treatment of painful skeletal muscle spasms.
Topics: Acetaminophen; Chlormezanone; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; | 1975 |
Oral treatment of skeletal muscle spasm with fluphenazine alone and combined with orphenadrine.
Topics: Adolescent; Adult; Clinical Trials as Topic; Female; Fluphenazine; Humans; Male; Middle Aged; Muscle | 1965 |
9 other studies available for orphenadrine and Cramp
| Article | Year |
|---|---|
Pareneral orphenadrine citrate in skeletal muscle spasm.
Topics: Databases, Genetic; Humans; Muscle Cramp; Muscle, Skeletal; Musculoskeletal System; Nervous System D | 1963 |
Oral treatment of skeletal muscle spasm: a double-blind clinical study.
Topics: Administration, Oral; Double-Blind Method; Fluphenazine; Humans; Muscle Cramp; Muscle, Skeletal; Mus | 1963 |
EXPERIENCES WITH A MUSCLE RELAXANT-ANALGESIC COMBINATION IN GENERAL PRACTICE.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Antipyretics; Family Practice; General Practice | 1963 |
EFFECTIVE OFFICE MANAGEMENT OF PAINFUL TRAUMATIC MUSCLE INJURIES.
Topics: Biomedical Research; Drug Therapy; Humans; Muscle Cramp; Muscular Diseases; Office Management; Orphe | 1964 |
RELAXATION OF DECEREBRATE RIGIDITY BY ORPHENADRINE.
Topics: Cats; Decerebrate State; Muscle Cramp; Nervous System Physiological Phenomena; Orphenadrine; Pharmac | 1964 |
[Therapeutic experiences with orphenadrine citrate Norflex].
Topics: Citrates; Female; Humans; Injections, Intravenous; Male; Middle Aged; Muscle Cramp; Muscles; Orphena | 1967 |
[Therapy of spastic syndromes].
Topics: Carisoprodol; Chlordiazepoxide; Chlormezanone; Chlorzoxazone; Curare; Diazepam; Guaifenesin; Humans; | 1969 |
Orphenadrine citrate (Norflex) for the treatment of "restless legs" and related syndromes.
Topics: Adult; Aged; Female; Humans; Leg; Male; Middle Aged; Muscle Cramp; Orphenadrine; Paresthesia | 1971 |
The effect of orphenadrine citrate by injection in skeletal muscle spasm using an electromyographic examination technique.
Topics: Electromyography; Humans; Injections, Intravenous; Muscle Cramp; Orphenadrine | 1969 |