orphenadrine has been researched along with Acute Pain in 4 studies
Orphenadrine: A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
orphenadrine : A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol.
Acute Pain: Intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo." | 9.27 | A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018) |
| "Among ED patients with acute, nontraumatic, nonradicular low back pain, combining naproxen with either orphenadrine or methocarbamol did not improve functional outcomes compared with naproxen+placebo." | 5.27 | A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. ( Cisewski, D; Davitt, M; Friedman, BW; Gallagher, EJ; Irizarry, E; Nassery, A; Pearlman, S; Solorzano, C; White, D, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amelin, AV | 1 |
| Tereshchenko, NM | 1 |
| Gotovchikov, AA | 1 |
| Abril, L | 1 |
| Zamora, C | 1 |
| Cordero, M | 1 |
| Williams, AR | 1 |
| Friedman, BW | 2 |
| Kiselev, DV | 1 |
| Lavrukhin, VV | 1 |
| Cisewski, D | 1 |
| Irizarry, E | 1 |
| Davitt, M | 1 |
| Solorzano, C | 1 |
| Nassery, A | 1 |
| Pearlman, S | 1 |
| White, D | 1 |
| Gallagher, EJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methocarbamol and Orphenadrine for Acute, Non-traumatic, Non-radicular Low Back Pain: A Randomized, Placebo Controlled, 3-armed Study[NCT02665286] | Phase 4 | 240 participants (Actual) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants with moderate to severe low back pain after treatment as report on the following ordinal scale: severe, moderate, mild, or none (NCT02665286)
Timeframe: 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 34 |
| Orphenadrine | 26 |
| Methocarbamol | 31 |
"Change in Roland Morris Disability Questionnaire between baseline and 1 week.~The low back pain functional disability scale is the RMDQ. The RMDQ is a 24-item low back pain functional scale recommended for use in low back pain research.Higher scores signify greater low back-related functional impairment.0= no functional impairment, 24= severe functional impairment." (NCT02665286)
Timeframe: 1 week
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 10.9 |
| Orphenadrine | 9.4 |
| Methocarbamol | 8.1 |
Participants still using medication such as analgesics for LBP after treatment (NCT02665286)
Timeframe: 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 42 |
| Orphenadrine | 40 |
| Methocarbamol | 50 |
The number of participants with affirmative response to the following question: Do you want the same medication combination during a subsequent episode of LBP. This is a patient-centered outcome that allows each individual to determine the desirability of the intervention. (NCT02665286)
Timeframe: 1 week
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 51 |
| Orphenadrine | 53 |
| Methocarbamol | 51 |
1 trial available for orphenadrine and Acute Pain
| Article | Year |
|---|---|
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.
Topics: Acute Pain; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela | 2018 |
3 other studies available for orphenadrine and Acute Pain
| Article | Year |
|---|---|
[Clinical experience with the use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome].
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Humans; Orphenadrine; Pain Measurem | 2021 |
The Relative Efficacy of Seven Skeletal Muscle Relaxants. An Analysis of Data From Randomized Studies.
Topics: Acute Pain; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Diazepam; Humans; Low Back Pain; Meth | 2022 |
[The use of a fixed combination of diclofenac and orphenadrine in the treatment of acute pain syndrome in patients with discogenic lumbosacral radiculopathy and lumboischialgia].
Topics: Acute Pain; Back Pain; Diclofenac; Humans; Orphenadrine; Radiculopathy | 2023 |