orotic acid has been researched along with Seizures in 13 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the effect of ethanol on the convulsion threshold as model of injuriousness to analyse the CNS protective efficacy of nootropics." | 1.27 | [Effect of nootropic agents on the lowering of the spasm threshold after a single ethanol application]. ( Andreas, K; Dienel, A; Schmidt, J, 1984) |
| "The enhanced seizure susceptibility after a single dose of ethanol was abolished by piracetam and MGO." | 1.27 | Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility. ( Andreas, K; Dienel, A; Schmidt, J, 1985) |
| "Orotic aciduria was present (max: 693 mg/day) and was related to NH4 levels." | 1.25 | [Chronic hyperammonemia with orotic aciduria: evidence of pyrimidine pathway stimulation (author's transl)]. ( Beaudry, MA; Collu, R; Dallairf, L; Ducharme, JR; Leboeuf, G; Letarte, J; Melancon, SB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (92.31) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KURTH, LE | 1 |
| KOENIG, H | 1 |
| FREYRE, J | 1 |
| Yamagami, S | 1 |
| Ohno, K | 1 |
| Tsuji, M | 1 |
| Mori, K | 1 |
| Kawakita, Y | 1 |
| Dienel, A | 2 |
| Andreas, K | 2 |
| Schmidt, J | 2 |
| Meerson, FZ | 1 |
| Mamalyga, LM | 1 |
| Beaudry, MA | 1 |
| Letarte, J | 1 |
| Collu, R | 1 |
| Leboeuf, G | 1 |
| Ducharme, JR | 1 |
| Melancon, SB | 1 |
| Dallairf, L | 1 |
| Rowe, PC | 1 |
| Newman, SL | 1 |
| Brusilow, SW | 1 |
| Dewar, AJ | 1 |
| Dow, RC | 1 |
| McQueen, JK | 1 |
| Goldstein, AS | 1 |
| Hoogenraad, NJ | 1 |
| Johnson, JD | 1 |
| Fukanaga, K | 1 |
| Swierczewski, E | 1 |
| Cann, HM | 1 |
| Sunshine, P | 1 |
| Baskin, F | 1 |
| Masiarz, FR | 1 |
| Agranoff, BW | 1 |
| Barbato, LM | 1 |
| Barbato, IW | 1 |
| Hamanaka, A | 1 |
| Ott, T | 1 |
| Matthies, H | 1 |
| Shashoua, VE | 1 |
13 other studies available for orotic acid and Seizures
| Article | Year |
|---|---|
Frontal lobe encephalopathy with focal seizures produced with pyrimidine analogs.
Topics: Disease; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Orotic Acid; Seizures | 1960 |
Developmental alteration in RNA metabolism of E1 mouse brain.
Topics: Aging; Animals; Brain; DNA; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Tissue Protein | 1981 |
[Effect of nootropic agents on the lowering of the spasm threshold after a single ethanol application].
Topics: Animals; Brain; Ethanol; Male; Meclofenoxate; Meglumine; Mice; Orotic Acid; Picrotoxin; Piracetam; P | 1984 |
[The protective action of adaptation to hypoxia in audiogenic epilepsy and its prolongation by using pharmacologic agents].
Topics: Acoustic Stimulation; Adaptation, Physiological; Animals; Benserazide; Brain; Brain Chemistry; Drug | 1994 |
[Chronic hyperammonemia with orotic aciduria: evidence of pyrimidine pathway stimulation (author's transl)].
Topics: Alanine; Amino Acids; Ammonia; Child, Preschool; Dietary Proteins; Erythrocytes; Growth Disorders; H | 1975 |
Natural history of symptomatic partial ornithine transcarbamylase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Ataxia; Child, Preschool; Coma; Diagnosis, Differenti | 1986 |
Influence of nootropic drugs on drinking behaviour in ethanol-preferring mice and ethanol-induced increase of seizure susceptibility.
Topics: Alcohol Drinking; Alcoholism; Animals; Dihydroergotoxine; Ethanol; Male; Meglumine; Mice; Mice, Inbr | 1985 |
RNA and protein metabolism in cobalt-induced epileptogenic lesions in rat brain.
Topics: Animals; Carbon Isotopes; Cobalt; DNA; Electroencephalography; Epilepsy; Leucine; Male; Motor Cortex | 1972 |
Metabolic and genetic studies of a family with ornithine transcarbamylase deficiency.
Topics: Ammonia; Ammonium Chloride; Brain; Citrates; Dietary Proteins; Estradiol; Glucose; Heterozygote; Hum | 1974 |
Effect of various stresses on the incorporation of ( 3 H)orotic acid into goldfish brain RNA.
Topics: Animals; Avoidance Learning; Brain; Carbon Dioxide; Cyprinidae; Cytosine Nucleotides; Electroshock; | 1972 |
The effect of insulin convulsions on the metabolism of RNA in the rabbit brain.
Topics: Animals; Brain; Carbon Isotopes; Cell Nucleus; Cytidine; Cytosine Nucleotides; Insulin; Microsomes; | 1972 |
[Effect of orotic acid on the retrograde amnesia induced by electroconvulsive shock].
Topics: Amnesia; Animals; Discrimination, Psychological; Electroshock; Extinction, Psychological; Humans; In | 1971 |
RNA metabolism in goldfish brain during acquisition of new behavioral patterns.
Topics: Animals; Behavior, Animal; Brain; Centrifugation, Density Gradient; Cyprinidae; Learning; Memory; Nu | 1970 |