orotic acid has been researched along with Myocardial Ischemia in 4 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Orotic acid treatment significantly improved post-ischaemic myocardial function and increased pre-ischaemic and post-ischaemic glycogen content of the heart." | 1.30 | Effects of orotic acid on ischaemic/reperfused myocardial function and glycogen content in isolated working rat hearts. ( Fazekas, T; Ferdinandy, P; Kádár, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pôrto, LC | 1 |
| de Castro, CH | 1 |
| Savergnini, SS | 1 |
| Santos, SH | 1 |
| Ferreira, AV | 1 |
| Cordeiro, LM | 1 |
| Sobrinho, DB | 1 |
| Santos, RA | 1 |
| de Almeida, AP | 1 |
| Botion, LM | 1 |
| Richards, SM | 2 |
| Conyers, RA | 2 |
| Fisher, JL | 1 |
| Rosenfeldt, FL | 2 |
| Ferdinandy, P | 1 |
| Fazekas, T | 1 |
| Kádár, E | 1 |
| Lin, Z | 1 |
| Pepe, S | 1 |
4 other studies available for orotic acid and Myocardial Ischemia
| Article | Year |
|---|---|
Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid.
Topics: Animals; Diet; Energy Metabolism; Fatty Acids; Glycolysis; Heart; Humans; Lipoprotein Lipase; Male; | 2012 |
Cardioprotection by orotic acid: metabolism and mechanism of action.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Heart; Liver; Male; Myocardial Infarction; Myocardi | 1997 |
Effects of orotic acid on ischaemic/reperfused myocardial function and glycogen content in isolated working rat hearts.
Topics: Animals; Glycogen; Heart; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial | 1998 |
Mechanism of cardioprotective effect of orotic acid.
Topics: Adenine Nucleotides; Animals; Heart; Hypoxia; In Vitro Techniques; Liver; Male; Myocardial Contracti | 1998 |