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orotic acid and Malaria

orotic acid has been researched along with Malaria in 12 studies

Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine."7.68Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. ( Gómez, ZM; Rathod, PK, 1990)
"Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine."3.68Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. ( Gómez, ZM; Rathod, PK, 1990)
") was tested alone, or in a double and triple combination with a fixed oral dose of 1."1.35Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model. ( Ishih, A; Kano, S; Kino, H; Muregi, FW, 2009)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19907 (58.33)18.7374
1990's4 (33.33)18.2507
2000's1 (8.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Muregi, FW1
Kano, S1
Kino, H1
Ishih, A1
Seymour, KK1
Lyons, SD1
Phillips, L1
Rieckmann, KH1
Christopherson, RI1
Krungkrai, J1
Krungkrai, SR1
Phakanont, K1
Rathod, PK2
Gomez, ZM2
Conklin, KA1
Chou, SC1
Siddiqui, WA1
Schnell, JV1
Peters, W1
Jacobs, RL1
Miller, LH1
Koontz, LC1
Barnes, MG1
Polet, H1
Tokuyasu, K1
Ilan, J2
Langer, BW1
Canfield, CJ1
Krooth, RS1
Wuu, KD1
Ma, R1

Reviews

1 review available for orotic acid and Malaria

ArticleYear
Summary of recent abstracts. 3. Malaria.2.
    Tropical diseases bulletin, 1973, Volume: 70, Issue:4

    Topics: Animals; Carbon Isotopes; Chloroquine; Dapsone; DNA; Drug Resistance, Microbial; Humans; Malaria; Or

1973

Other Studies

11 other studies available for orotic acid and Malaria

ArticleYear
Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model.
    Experimental parasitology, 2009, Volume: 121, Issue:4

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Synergism; Drug Therapy, Combination

2009
Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum.
    Biochemistry, 1994, May-03, Volume: 33, Issue:17

    Topics: Amides; Animals; Antimalarials; Atovaquone; Bicarbonates; Carbon Radioisotopes; Chromatography, High

1994
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase.
    Biochemical pharmacology, 1992, Mar-17, Volume: 43, Issue:6

    Topics: Animals; Antimalarials; Chloroquine; Dihydroorotase; Dihydroorotate Dehydrogenase; Kinetics; Macroph

1992
Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice.
    Experimental parasitology, 1991, Volume: 73, Issue:4

    Topics: Administration, Oral; Animals; Antimalarials; Injections, Intraperitoneal; Malaria; Mice; Orotic Aci

1991
Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:7

    Topics: Animals; Drug Combinations; Malaria; Male; Mice; Orotic Acid; Plasmodium yoelii; Uridine

1990
DNA and RNA syntheses by intraerythrocytic stages of Plasmodium knowlesi.
    The Journal of protozoology, 1973, Volume: 20, Issue:5

    Topics: Adenosine; Animals; Carbon Radioisotopes; Cell Count; DNA; Erythrocytes; Haplorhini; Macaca; Malaria

1973
Labeling of sporozoites of Plasmodium berghei with tritiated purines.
    The Journal of parasitology, 1974, Volume: 60, Issue:2

    Topics: Adenine; Adenosine; Animals; Anopheles; Blood; Deoxyadenosines; Deoxyribonucleosides; Guanosine; Iso

1974
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
    The Journal of laboratory and clinical medicine, 1969, Volume: 74, Issue:1

    Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria;

1969
Biogenesis of ribosomes in Plasmodium berghei.
    Military medicine, 1969, Volume: 134, Issue:10

    Topics: Animals; Carbon Isotopes; Culture Techniques; Malaria; Mice; Orotic Acid; Phosphorus Isotopes; Plasm

1969
Methionine analogue metabolism in malaria.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971, Volume: 65, Issue:1

    Topics: Aspartate Aminotransferases; Carbon Isotopes; DNA; Malaria; Methionine; Orotic Acid; Plasmodium; RNA

1971
Dihydroorotic acid dehydrogenase: introduction into erythrocyte by the malaria parasite.
    Science (New York, N.Y.), 1969, May-30, Volume: 164, Issue:3883

    Topics: Animals; Dialysis; Erythrocytes; Malaria; Mice; Orotic Acid; Oxidoreductases; Plasmodium; Rats

1969