orotic acid has been researched along with Malaria in 12 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine." | 7.68 | Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. ( Gómez, ZM; Rathod, PK, 1990) |
| "Malarial parasites, in contrast to mammalian cells, utilize orotic acid more efficiently than uracil or uridine." | 3.68 | Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice. ( Gómez, ZM; Rathod, PK, 1990) |
| ") was tested alone, or in a double and triple combination with a fixed oral dose of 1." | 1.35 | Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model. ( Ishih, A; Kano, S; Kino, H; Muregi, FW, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Muregi, FW | 1 |
| Kano, S | 1 |
| Kino, H | 1 |
| Ishih, A | 1 |
| Seymour, KK | 1 |
| Lyons, SD | 1 |
| Phillips, L | 1 |
| Rieckmann, KH | 1 |
| Christopherson, RI | 1 |
| Krungkrai, J | 1 |
| Krungkrai, SR | 1 |
| Phakanont, K | 1 |
| Rathod, PK | 2 |
| Gomez, ZM | 2 |
| Conklin, KA | 1 |
| Chou, SC | 1 |
| Siddiqui, WA | 1 |
| Schnell, JV | 1 |
| Peters, W | 1 |
| Jacobs, RL | 1 |
| Miller, LH | 1 |
| Koontz, LC | 1 |
| Barnes, MG | 1 |
| Polet, H | 1 |
| Tokuyasu, K | 1 |
| Ilan, J | 2 |
| Langer, BW | 1 |
| Canfield, CJ | 1 |
| Krooth, RS | 1 |
| Wuu, KD | 1 |
| Ma, R | 1 |
1 review available for orotic acid and Malaria
| Article | Year |
|---|---|
Summary of recent abstracts. 3. Malaria.2.
Topics: Animals; Carbon Isotopes; Chloroquine; Dapsone; DNA; Drug Resistance, Microbial; Humans; Malaria; Or | 1973 |
11 other studies available for orotic acid and Malaria
| Article | Year |
|---|---|
Plasmodium berghei: efficacy of 5-fluoroorotate in combination with commonly used antimalarial drugs in a mouse model.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Dapsone; Drug Synergism; Drug Therapy, Combination | 2009 |
Cytotoxic effects of inhibitors of de novo pyrimidine biosynthesis upon Plasmodium falciparum.
Topics: Amides; Animals; Antimalarials; Atovaquone; Bicarbonates; Carbon Radioisotopes; Chromatography, High | 1994 |
Antimalarial activity of orotate analogs that inhibit dihydroorotase and dihydroorotate dehydrogenase.
Topics: Animals; Antimalarials; Chloroquine; Dihydroorotase; Dihydroorotate Dehydrogenase; Kinetics; Macroph | 1992 |
Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice.
Topics: Administration, Oral; Animals; Antimalarials; Injections, Intraperitoneal; Malaria; Mice; Orotic Aci | 1991 |
Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice.
Topics: Animals; Drug Combinations; Malaria; Male; Mice; Orotic Acid; Plasmodium yoelii; Uridine | 1990 |
DNA and RNA syntheses by intraerythrocytic stages of Plasmodium knowlesi.
Topics: Adenosine; Animals; Carbon Radioisotopes; Cell Count; DNA; Erythrocytes; Haplorhini; Macaca; Malaria | 1973 |
Labeling of sporozoites of Plasmodium berghei with tritiated purines.
Topics: Adenine; Adenosine; Animals; Anopheles; Blood; Deoxyadenosines; Deoxyribonucleosides; Guanosine; Iso | 1974 |
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi.
Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria; | 1969 |
Biogenesis of ribosomes in Plasmodium berghei.
Topics: Animals; Carbon Isotopes; Culture Techniques; Malaria; Mice; Orotic Acid; Phosphorus Isotopes; Plasm | 1969 |
Methionine analogue metabolism in malaria.
Topics: Aspartate Aminotransferases; Carbon Isotopes; DNA; Malaria; Methionine; Orotic Acid; Plasmodium; RNA | 1971 |
Dihydroorotic acid dehydrogenase: introduction into erythrocyte by the malaria parasite.
Topics: Animals; Dialysis; Erythrocytes; Malaria; Mice; Orotic Acid; Oxidoreductases; Plasmodium; Rats | 1969 |