orotic acid has been researched along with Liver Steatosis in 126 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the peroxisome proliferator, dehydroepiandrosterone sulfate (DHEAS), and the typical cytochrome P450 (CYP) inducers phenobarbital (PB) and 3-methylcholanthrene (3-MC) on fatty liver were examined in rats." | 7.81 | Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet. ( Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H, 2015) |
| "Fatty liver is caused when rats are given orotic acid of the pyrimidine base in large quantities." | 7.81 | Effects of Fatty Liver Induced by Excess Orotic Acid on B-Group Vitamin Concentrations of Liver, Blood, and Urine in Rats. ( Fukuwatari, T; Kawamura, T; Morita, N; Shibata, K; Tsuji, A, 2015) |
| "The aim of this study was to investigate the possible mechanism of orotic acid-induced fatty liver in rats." | 7.77 | Study on possible mechanism of orotic acid-induced fatty liver in rats. ( Hu, XQ; Li, ZJ; Wang, YM; Xue, CH; Xue, Y; Yanagita, T, 2011) |
| "We compared the efficacy of alpha-linolenic acid (alpha-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats." | 7.72 | Alleviation of fatty liver by alpha-linolenic acid. ( Buang, Y; Cha, JY; Inoue, N; Nagao, K; Wang, YM; Yanagita, T, 2004) |
| " Orotic acid-induced fatty liver disease was investigated at the transcriptional and metabolic levels using microarrays and metabolic profiling in two strains of rats." | 7.72 | An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. ( Bonney, SA; Gibbons, GF; Griffin, JL; Hebbachi, AM; Mann, C; Nicholson, JK; Scott, J; Shoulders, CC, 2004) |
| "Preventive effects of dehydroepiandrosteone acetate (DHEA-A) and clofibrate (positive control substance) on the fatty liver induced by orotic acid (OA) were examined on the male Sprague-Dawley rats fed a high sucrose based diet containing 1% OA and this diet further mixed with 0." | 7.70 | Preventive effects of dehydroepiandrosterone acetate on the fatty liver induced by orotic acid in male rats. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| " The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB)." | 7.70 | Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| " Orotic acid and estrogen, which both modify lipid metabolism in the liver, were used in male geese as tools to understand the alterations of liver lipids and plasma lipoproteins during the induction of liver steatosis." | 7.69 | Influence of orotic acid and estrogen on hepatic lipid storage and secretion in the goose susceptible to liver steatosis. ( Hermier, D; Peresson, R; Rousselot-Pailley, D; Sellier, N, 1994) |
| "Orotic acid-induced fatty livers were examined by biochemical and immunohistochemical approaches." | 7.68 | Biochemical and immunohistochemical analysis of orotic acid-induced fatty liver. ( Misawa, M; Murakoshi, M; Suemizu, H; Takekoshi, S; Watanabe, K, 1991) |
| "The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid." | 7.67 | Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989) |
| "Fatty liver was induced in Wistar rats by orotic acid and the recovery process was studied by enzyme histochemical staining for non specific esterase, lipase and by ultrastructural investigation." | 7.67 | Enzyme histochemical and ultrastructural approach in orotic acid-induced fatty liver and their recovery process in Wistar rats. ( Murakoshi, M; Suemizu, H; Watanabe, K, 1988) |
| "Rats fed orotic acid develop fatty livers characterized by triglyceride-laden, membrane-bounded vesicles designated "liposomes." | 7.67 | Apolipoproteins of the orotic acid fatty liver: implications for the biogenesis of plasma lipoproteins. ( Fleming, R; Hay, R; Kirschner, J; O'Connell, W; Oppliger, W, 1988) |
| "The addition of 1 per cent orotic acid to a sucrose-enriched semipurified diet results in markedly fatty liver when fed to rats for 7 to 22 days." | 7.65 | Reversal of orotic acid-induced fatty liver in rats by clofibrate. ( Edelstein, D; Novikoff, PM, 1977) |
| "Fatty liver is caused when rats are given orotic acid of the pyrimidine base in large quantities." | 3.81 | Effects of Fatty Liver Induced by Excess Orotic Acid on B-Group Vitamin Concentrations of Liver, Blood, and Urine in Rats. ( Fukuwatari, T; Kawamura, T; Morita, N; Shibata, K; Tsuji, A, 2015) |
| "The effects of the peroxisome proliferator, dehydroepiandrosterone sulfate (DHEAS), and the typical cytochrome P450 (CYP) inducers phenobarbital (PB) and 3-methylcholanthrene (3-MC) on fatty liver were examined in rats." | 3.81 | Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet. ( Goto, H; Ito, Y; Matsumoto, S; Sato, M; Senba, T; Takeuchi, K; Umehara, K; Yamada, H, 2015) |
| " The fatty liver model was established by administration of 1% orotic acid (OA) to the rats." | 3.78 | Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. ( Hu, X; Li, Z; Wang, J; Wang, Y; Xu, J; Xue, C; Xue, Y; Yanagita, T; Zhang, B, 2012) |
| "The aim of this study was to investigate the possible mechanism of orotic acid-induced fatty liver in rats." | 3.77 | Study on possible mechanism of orotic acid-induced fatty liver in rats. ( Hu, XQ; Li, ZJ; Wang, YM; Xue, CH; Xue, Y; Yanagita, T, 2011) |
| " We also investigated the anti-fatty liver activity of AMC-2 in rats with fatty liver induced by orotic acid." | 3.77 | Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides. ( Feng, TY; Sugawara, T; Wang, YM; Xu, J; Xue, CH; Zhang, B, 2011) |
| " Fatty liver induced in rats by chronic orotic acid feeding was investigated using this modified sequence." | 3.72 | High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue. ( Griffin, JL; Nicholson, JK; Rooney, OM; Troke, J, 2003) |
| " Orotic acid-induced fatty liver disease was investigated at the transcriptional and metabolic levels using microarrays and metabolic profiling in two strains of rats." | 3.72 | An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. ( Bonney, SA; Gibbons, GF; Griffin, JL; Hebbachi, AM; Mann, C; Nicholson, JK; Scott, J; Shoulders, CC, 2004) |
| "We compared the efficacy of alpha-linolenic acid (alpha-LNA, n-3) and linoleic acid (LA, n-6) on orotic acid (OA)-induced fatty liver in Sprague-Dawley rats." | 3.72 | Alleviation of fatty liver by alpha-linolenic acid. ( Buang, Y; Cha, JY; Inoue, N; Nagao, K; Wang, YM; Yanagita, T, 2004) |
| "Orotic acid is known to cause fatty liver, but it is unclear whether this is caused partly by stimulation of the enzymes for triacylglycerol (TG) synthesis." | 3.70 | Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats. ( Cha, JY; Mameda, Y; Oogami, K; Yamamoto, K; Yanagita, T, 1998) |
| " The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital (PB)." | 3.70 | Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| "Preventive effects of dehydroepiandrosteone acetate (DHEA-A) and clofibrate (positive control substance) on the fatty liver induced by orotic acid (OA) were examined on the male Sprague-Dawley rats fed a high sucrose based diet containing 1% OA and this diet further mixed with 0." | 3.70 | Preventive effects of dehydroepiandrosterone acetate on the fatty liver induced by orotic acid in male rats. ( Goto, H; Makita, T; Yamashita, S, 1998) |
| " Orotic acid and estrogen, which both modify lipid metabolism in the liver, were used in male geese as tools to understand the alterations of liver lipids and plasma lipoproteins during the induction of liver steatosis." | 3.69 | Influence of orotic acid and estrogen on hepatic lipid storage and secretion in the goose susceptible to liver steatosis. ( Hermier, D; Peresson, R; Rousselot-Pailley, D; Sellier, N, 1994) |
| "The purpose of this study was to ascertain the changes in nitrogen balance, plasma free amino acid concentrations, urinary orotic acid excretion and body weight during long-term fasting in adult obese cats." | 3.69 | Nitrogen balance, plasma free amino acid concentrations and urinary orotic acid excretion during long-term fasting in cats. ( Bee, D; Biourge, V; Fisher, C; Groff, JM; Morris, JG; Rogers, QR, 1994) |
| "Using a spectrometer (n = 60) in vitro and MRT imaging (n = 8) in vivo, we studied the influence of fatty changes of liver cells on the relaxation times of the liver (two animal models of fatty liver disease/orotic acid, L-ethionine)." | 3.69 | [Animal experiment studies on the influence of fatty infiltration of liver cells on tissue relaxation times and signal changes in magnetic resonance tomography]. ( Kreft, B; Schild, H; Stark, D, 1995) |
| "Branched-chain amino acid aminotransferase activities were measured in rats in which hepatic lesions were induced experimentally, that is, fatty liver produced by an orotic acid-containing diet and acute hepatic lesion induced by D-galactosamine injection into the abdominal cavity." | 3.69 | Changes in activity levels and isozyme patterns of isoleucine aminotransferase in response to experimentally induced hepatic lesion. ( Kobayashi, Y; Kuratomi, K; Miyazawa, H; Sasanuma, A, 1995) |
| "Orotic acid-induced fatty livers were examined by biochemical and immunohistochemical approaches." | 3.68 | Biochemical and immunohistochemical analysis of orotic acid-induced fatty liver. ( Misawa, M; Murakoshi, M; Suemizu, H; Takekoshi, S; Watanabe, K, 1991) |
| "Fatty liver was induced in Wistar rats by orotic acid and the recovery process was studied by enzyme histochemical staining for non specific esterase, lipase and by ultrastructural investigation." | 3.67 | Enzyme histochemical and ultrastructural approach in orotic acid-induced fatty liver and their recovery process in Wistar rats. ( Murakoshi, M; Suemizu, H; Watanabe, K, 1988) |
| "The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid." | 3.67 | Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989) |
| "Rats fed orotic acid develop fatty livers characterized by triglyceride-laden, membrane-bounded vesicles designated "liposomes." | 3.67 | Apolipoproteins of the orotic acid fatty liver: implications for the biogenesis of plasma lipoproteins. ( Fleming, R; Hay, R; Kirschner, J; O'Connell, W; Oppliger, W, 1988) |
| "Groups of normal and heterozygote sparse-fur (spf) mutant mice were studied at various stages of gestation, to assess the effects of normal pregnancy on orotate excretion, hepatic mitochondrial urea cycle enzymes and any predisposition to the development of fatty liver." | 3.67 | The role of hepatic ornithine transcarbamylase deficiency in the orotic aciduria of pregnant mice. ( Letarte, J; Qureshi, IA; Qureshi, SR; Tuchweber, B; Yousef, I, 1986) |
| "The addition of 1 per cent orotic acid to a sucrose-enriched semipurified diet results in markedly fatty liver when fed to rats for 7 to 22 days." | 3.65 | Reversal of orotic acid-induced fatty liver in rats by clofibrate. ( Edelstein, D; Novikoff, PM, 1977) |
| "This study provides confirmation of previous observations that showed that rats fed a diet containing 1% orotic acid for 7 days develop a fatty liver and that there is an inhibition of the secretion of low density lipoproteins without altering general liver protein synthesis." | 3.65 | Serum lipoprotein accumulation in the livers of orotic acid-fed rats. ( Getz, GS; Pottenger, LA, 1971) |
| "Orotic acid is an important representative of the pyrimidines, the pathophysiological importance of which is less well-known in comparison to the purines." | 2.65 | [Metabolic effects of orotic acid]. ( Müller, G, 1984) |
| "In rats with steatohepatitis, mean elasticity (2." | 1.35 | Early detection of steatohepatitis in fatty rat liver by using MR elastography. ( Abarca-Quinones, J; Dorvillius, M; Fink, M; Larrat, B; Leclercq, I; Pallu, S; Salameh, N; Sinkus, R; Van Beers, BE, 2009) |
| " Lipid deposition in livers of patients with the metabolic syndrome may necessitate dosage adjustments for toxic drugs, including CLZ." | 1.34 | Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis. ( Murray, M; Ramzan, I; Zhang, WV, 2007) |
| "Fatty liver is known to be associated with increased mortality and morbidity after liver resection." | 1.31 | Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. ( Horsmans, Y; Lambotte, L; Picard, C; Saliez, A; Sempoux, C; Starkel, P; Van den Berge, V, 2002) |
| "Most concentrations of OA used in this study did not induce HL in cats during a 29-day period, but the highest dosage used did result in renal disease." | 1.30 | Effects of oral administration of orotic acid on hepatic morphologic characteristics and serum biochemical variables in cats. ( Dimski, DS; Hosgood, G; Swenson, DH; Taboada, J; Taylor, HW; VanSteenhouse, JL, 1999) |
| "The increase in neutral lipids during CCl4 poisoning is significantly reduced by pretreatment and--somewhat less--by posttreatment with EPL." | 1.25 | Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents. ( Bartsch, GG; Gerber, GB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 96 (76.19) | 18.7374 |
| 1990's | 13 (10.32) | 18.2507 |
| 2000's | 7 (5.56) | 29.6817 |
| 2010's | 9 (7.14) | 24.3611 |
| 2020's | 1 (0.79) | 2.80 |
| Authors | Studies |
|---|---|
| Müller, FA | 1 |
| Stamou, M | 1 |
| Englert, FH | 1 |
| Frenzel, O | 1 |
| Diedrich, S | 1 |
| Suter-Dick, L | 1 |
| Wambaugh, JF | 1 |
| Sturla, SJ | 1 |
| García-Heredia, A | 1 |
| Kensicki, E | 1 |
| Mohney, RP | 1 |
| Rull, A | 1 |
| Triguero, I | 1 |
| Marsillach, J | 1 |
| Tormos, C | 1 |
| Mackness, B | 1 |
| Mackness, M | 1 |
| Shih, DM | 1 |
| Pedro-Botet, J | 1 |
| Joven, J | 1 |
| Sáez, G | 1 |
| Camps, J | 1 |
| Hong, ES | 1 |
| Kim, EK | 1 |
| Kang, SM | 1 |
| Khang, AR | 1 |
| Choi, SH | 1 |
| Park, KS | 1 |
| Jang, HC | 1 |
| Lim, S | 1 |
| Takeuchi, K | 1 |
| Goto, H | 3 |
| Ito, Y | 1 |
| Sato, M | 1 |
| Matsumoto, S | 1 |
| Senba, T | 1 |
| Yamada, H | 1 |
| Umehara, K | 1 |
| Shibata, K | 2 |
| Morita, N | 1 |
| Kawamura, T | 1 |
| Tsuji, A | 1 |
| Fukuwatari, T | 2 |
| Salameh, N | 1 |
| Larrat, B | 1 |
| Abarca-Quinones, J | 1 |
| Pallu, S | 1 |
| Dorvillius, M | 1 |
| Leclercq, I | 1 |
| Fink, M | 1 |
| Sinkus, R | 1 |
| Van Beers, BE | 1 |
| Hu, XQ | 2 |
| Wang, YM | 4 |
| Wang, JF | 1 |
| Xue, Y | 3 |
| Li, ZJ | 2 |
| Nagao, K | 2 |
| Yanagita, T | 5 |
| Xue, CH | 3 |
| Jung, EJ | 1 |
| Kwon, SW | 1 |
| Jung, BH | 1 |
| Oh, SH | 1 |
| Lee, BH | 1 |
| Xu, J | 2 |
| Feng, TY | 1 |
| Zhang, B | 2 |
| Sugawara, T | 1 |
| Xue, C | 1 |
| Hu, X | 1 |
| Li, Z | 1 |
| Wang, J | 1 |
| Wang, Y | 1 |
| Morikawa, Y | 1 |
| Sugimoto, E | 1 |
| STANDERFER, SB | 1 |
| HANDLER, P | 1 |
| CREASEY, WA | 1 |
| HANKIN, L | 1 |
| HANDSCHUMACHER, RE | 4 |
| HATAKEYAMA, T | 1 |
| RAJALAKSHMI, S | 3 |
| SARMA, DS | 4 |
| SARMA, PS | 3 |
| HAYANO, K | 1 |
| TSUBONE, T | 1 |
| AZUMA, I | 1 |
| YAMAMURA, Y | 1 |
| SRIRAMACHARI, S | 2 |
| SIDRANSKY, H | 7 |
| VON EULER, LH | 2 |
| RUBIN, RJ | 1 |
| Verney, E | 4 |
| Lombardi, B | 1 |
| KOBATA, A | 1 |
| FURUNO, K | 2 |
| SUZUOKI-ZIR, O | 1 |
| NOMURA, T | 1 |
| TANAKA, T | 1 |
| HENDERSON, JF | 1 |
| WINDMUELLER, HG | 4 |
| MARCHETTI, M | 3 |
| PUDDU, P | 3 |
| MCDANIEL, EG | 1 |
| SPAETH, A | 1 |
| DEAMER, DW | 1 |
| KRUGER, FA | 1 |
| CORNWELL, DG | 1 |
| JATLOW, P | 1 |
| ADAMS, WR | 2 |
| GREAVES, JP | 1 |
| Rooney, OM | 1 |
| Troke, J | 1 |
| Nicholson, JK | 2 |
| Griffin, JL | 2 |
| Bonney, SA | 1 |
| Mann, C | 1 |
| Hebbachi, AM | 1 |
| Gibbons, GF | 1 |
| Shoulders, CC | 1 |
| Scott, J | 1 |
| Buang, Y | 1 |
| Cha, JY | 2 |
| Inoue, N | 1 |
| Zhang, WV | 1 |
| Ramzan, I | 1 |
| Murray, M | 2 |
| Levy, RI | 1 |
| Radomski, MW | 1 |
| Orme, T | 1 |
| Kinsella, JE | 2 |
| Blanding, JH | 1 |
| Tremblay, GC | 2 |
| Müller, G | 1 |
| Ulman, EA | 1 |
| Ifft, KH | 1 |
| Kari, FW | 1 |
| Visek, WJ | 2 |
| Miyazawa, S | 1 |
| Furuta, S | 1 |
| Hashimoto, T | 1 |
| Martin, A | 1 |
| Biol, MC | 1 |
| Raisonnier, A | 1 |
| Infante, R | 1 |
| Louisot, P | 1 |
| Richard, M | 1 |
| Milner, JA | 2 |
| Hassan, AS | 1 |
| Terada, M | 1 |
| Wakusawa, S | 1 |
| Watanabe, Y | 1 |
| Kato, M | 1 |
| Hayashi, M | 1 |
| Hayashi, E | 1 |
| Menninger, U | 1 |
| Menninger, W | 1 |
| Kobayashi, Y | 1 |
| Miyazawa, H | 1 |
| Sasanuma, A | 1 |
| Kuratomi, K | 1 |
| Kreft, B | 1 |
| Stark, D | 1 |
| Schild, H | 1 |
| Biourge, V | 2 |
| Groff, JM | 2 |
| Morris, JG | 2 |
| Rogers, QR | 2 |
| Fisher, C | 1 |
| Bee, D | 1 |
| Hermier, D | 1 |
| Rousselot-Pailley, D | 1 |
| Peresson, R | 1 |
| Sellier, N | 1 |
| Sadanobu, S | 1 |
| Takeuchi, M | 1 |
| Tezuka, M | 1 |
| Mameda, Y | 1 |
| Yamamoto, K | 1 |
| Oogami, K | 1 |
| Yamashita, S | 2 |
| Makita, T | 2 |
| VanSteenhouse, JL | 2 |
| Dimski, DS | 2 |
| Taylor, HW | 1 |
| Swenson, DH | 2 |
| Taboada, J | 2 |
| Hosgood, G | 1 |
| Su, GM | 1 |
| Sefton, RM | 1 |
| Picard, C | 1 |
| Lambotte, L | 1 |
| Starkel, P | 1 |
| Sempoux, C | 1 |
| Saliez, A | 1 |
| Van den Berge, V | 1 |
| Horsmans, Y | 1 |
| Cenedella, RJ | 1 |
| Shimakawa, K | 1 |
| Suzuoki, Z | 1 |
| Porta, EA | 1 |
| Korycka-Dahl, M | 1 |
| Richardson, T | 1 |
| Amundson, CH | 1 |
| Allen, JR | 1 |
| Negishi, I | 2 |
| Aizawa, Y | 2 |
| Sabesin, SM | 1 |
| Frase, S | 1 |
| Ragland, JB | 1 |
| Yousufzai, SY | 1 |
| Siddiqi, M | 1 |
| Thaler, MM | 1 |
| Novikoff, PM | 2 |
| Edelstein, D | 2 |
| Carrella, M | 1 |
| Björkhem, I | 1 |
| Gustafsson, JA | 1 |
| Einarsson, K | 1 |
| Hellström, K | 1 |
| Bartsch, GG | 1 |
| Gerber, GB | 1 |
| Murakoshi, M | 3 |
| Suemizu, H | 2 |
| Takekoshi, S | 1 |
| Misawa, M | 2 |
| Watanabe, K | 3 |
| Maswoswe, SM | 1 |
| Hay, R | 1 |
| Fleming, R | 1 |
| O'Connell, W | 1 |
| Kirschner, J | 1 |
| Oppliger, W | 1 |
| O'Brien, WD | 1 |
| Erdman, JW | 1 |
| Hebner, TB | 1 |
| Qureshi, IA | 1 |
| Letarte, J | 1 |
| Tuchweber, B | 1 |
| Yousef, I | 1 |
| Qureshi, SR | 1 |
| Wallnöfer, H | 1 |
| Vaishwanar, I | 2 |
| Jiddewar, GG | 2 |
| Amrutavalli, E | 1 |
| Petzold, H | 1 |
| Storch, H | 1 |
| Hohlfeld, R | 1 |
| Wagle, DS | 1 |
| Novikoff, AB | 2 |
| Roheim, PS | 4 |
| Quintana, N | 1 |
| Hamuro, Y | 1 |
| Gajdos, A | 1 |
| Gajdos-Tërök, M | 1 |
| Horn, R | 1 |
| Feo, C | 1 |
| Garçon, E | 1 |
| Pottenger, LA | 1 |
| Getz, GS | 1 |
| Okonkwo, PO | 1 |
| Philippen, R | 1 |
| O'Sullivan, WJ | 1 |
| Witting, LA | 2 |
| Shukla, RD | 1 |
| Kowale, CN | 1 |
| Edreira, JG | 1 |
| Hirsch, RL | 1 |
| Kennedy, JA | 1 |
| Westerfeld, WW | 3 |
| Elwood, JC | 2 |
| Richert, DA | 2 |
| Négret, JP | 1 |
| Bloom, RJ | 1 |
| Wexler, BC | 1 |
| Judd, JT | 1 |
| Lutmer, RF | 1 |
| Saroff, J | 1 |
| Torrielli, MV | 1 |
| Ugazio, G | 1 |
| Kotaki, A | 1 |
| Okumura, M | 1 |
| Hasan, SH | 1 |
| Yagi, K | 1 |
| Moruzzi, G | 1 |
| Simon, JB | 2 |
| Scheig, R | 2 |
| Klatskin, G | 2 |
| Bianchi, FB | 1 |
| Cavalli, G | 1 |
| Pisi, E | 1 |
| Sotgiu, G | 1 |
| Kayden, HJ | 1 |
| Glassman, MI | 1 |
| Medick, M | 1 |
| Bunyan, J | 1 |
| Cawthorne, MA | 1 |
| Diplock, AT | 1 |
| Green, J | 1 |
| Yajima, Y | 1 |
| Bloomfield, RA | 1 |
| Letter, AA | 1 |
| Wilson, RP | 1 |
| Caldarera, CM | 1 |
| Switzer, S | 2 |
| Girard, A | 2 |
| Eder, HA | 2 |
| Zaki, GF | 1 |
| Rommel, K | 1 |
| Georg, D | 1 |
| Mähr, G | 1 |
| Török, M | 1 |
3 reviews available for orotic acid and Liver Steatosis
| Article | Year |
|---|---|
Nutrition and diseases of the liver and gallbladder.
Topics: Alcoholism; Animals; Atrophy; Avitaminosis; Fatty Acids, Essential; Fatty Liver; Gallbladder Disease | 1975 |
Metabolic mechanisms in Reye syndrome. End of a Mystery?
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Aspirin; Brain Diseases; Carbamoyl-Phosphate Synthase | 1976 |
Orotic acid.
Topics: Allopurinol; Anemia, Pernicious; Animals; Azauridine; Carboxy-Lyases; Fatty Liver; Female; Humans; I | 1973 |
2 trials available for orotic acid and Liver Steatosis
| Article | Year |
|---|---|
Effect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled study.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Biomarkers; Blood Glucose; Carnitine; DNA | 2014 |
[Metabolic effects of orotic acid].
Topics: Animals; Fatty Liver; Humans; Hyperlipoproteinemias; Lipids; Liver; Orotate Phosphoribosyltransferas | 1984 |
121 other studies available for orotic acid and Liver Steatosis
| Article | Year |
|---|---|
In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Fatty Liver | 2023 |
Paraoxonase-1 deficiency is associated with severe liver steatosis in mice fed a high-fat high-cholesterol diet: a metabolomic approach.
Topics: Amino Acids; Animals; Aryldialkylphosphatase; Biomarkers; Cholesterol; Diet, High-Fat; Fatty Liver; | 2013 |
Dehydroepiandrosterone sulfate and cytochrome P450 inducers alleviate fatty liver in male rats fed an orotic acid-supplemented diet.
Topics: Animals; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone Su | 2015 |
Effects of Fatty Liver Induced by Excess Orotic Acid on B-Group Vitamin Concentrations of Liver, Blood, and Urine in Rats.
Topics: Animals; Biotin; Fatty Liver; Folic Acid; Liver; Male; Niacin; Orotic Acid; Pantothenic Acid; Rats; | 2015 |
Early detection of steatohepatitis in fatty rat liver by using MR elastography.
Topics: Animals; Carbon Tetrachloride; Choline Deficiency; Elasticity Imaging Techniques; Fatty Liver; Male; | 2009 |
Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling.
Topics: Animal Feed; Animals; Cholesterol; Fatty Liver; Male; Orotic Acid; Plant Extracts; PPAR alpha; Rats; | 2010 |
Study on possible mechanism of orotic acid-induced fatty liver in rats.
Topics: Animals; Carnitine O-Palmitoyltransferase; Cholesterol; Cholesterol, VLDL; Diet; Fatty Acid Synthase | 2011 |
Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Cell Line; Enzyme Acti | 2011 |
Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides.
Topics: Administration, Oral; Animals; Cerebrosides; Cholesterol; Fatty Acids; Fatty Liver; Gas Chromatograp | 2011 |
Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.
Topics: Animals; Antimetabolites; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cerebrosides; Dietary | 2012 |
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
Topics: Animals; Diet; Fats; Fatty Liver; Feeding Behavior; Liver; Male; NAD; NADP; Niacin; Organ Size; Orot | 2002 |
Fatty liver induced by orotic acid feeding.
Topics: Fatty Liver; Liver Diseases; Orotic Acid | 1955 |
Fatty livers induced by orotic acid. I. Accumulation and metabolism of lipids.
Topics: Fatty Liver; Lipids; Liver; Orotic Acid | 1961 |
[Studies on nutrition and hepatic injury. 4. Studies on experimental fatty liver; effects of addition of lipoic acid, orotic acid, lvsine, threonine, and fermented sovbeans].
Topics: Fatty Liver; Glycine max; Liver Diseases; Lysine; Nutritional Status; Orotic Acid; Thioctic Acid; Th | 1961 |
Studies on 'orotic acid fatty liver'.
Topics: Cholesterol; Fatty Liver; Lipid Metabolism; Liver; Orotic Acid | 1961 |
The prevention of the orotic acid fatty liver by the administration of 5-aminoimidazolecarboxamide.
Topics: Amides; Fatty Liver; Imidazoles; Orotic Acid | 1962 |
Experimental dietary cirrhosis.
Topics: Animals; Choline; Cystine; Diet; Fatty Liver; Humans; Liver Cirrhosis, Experimental; Methionine; Oro | 1962 |
Sex difference in induction of fatty liver in the rat by dietary orotic acid.
Topics: Animals; Diet; Fatty Liver; Orotic Acid; Rats; Sex Characteristics | 1963 |
Fatty livers induced by orotic acid. II. Changes in nucleotide metabolism.
Topics: Adenine Nucleotides; Body Composition; Fatty Liver; Nucleotides; Orotic Acid; Uracil Nucleotides | 1963 |
FACTORS INFLUENCING THE INDUCTION OF FATTY LIVER BY OROTIC ACID.
Topics: Albumins; Caseins; Cytosine; Diet; Fatty Liver; Glycine max; Guanine; Nucleosides; Orotic Acid; Rats | 1963 |
THE CHEMICAL COMPONENTS OF MILK WHICH PREVENT THE FATTY LIVER INDUCED BY OROTIC ACID.
Topics: Calcium; Fatty Liver; Lactose; Liver; Milk; Orotic Acid; Research | 1964 |
[HISTOLOGICAL STUDY ON NUCLEIC ACIDS OF THE LIVER IN DIETARY LIVER DISORDERS. 2. THE RESULTS IN THE GROUPS FED BUCKWHEAT WITH ANTI-FATTY LIVER AGENTS].
Topics: Animals; Caseins; Diet; Edible Grain; Fagopyrum; Fatty Liver; Folic Acid; Liver; Methionine; Mice; N | 1964 |
[THE RELATION BETWEEN FATTY METAMORPHOSIS AND FIBROSIS AND THE EFFECTS OF JOINT USE OF OROTIC ACID AND PURINE BODIES].
Topics: Cholesterol; DNA; Fatty Liver; Hexosamines; Hydroxyproline; Lipid Metabolism; Liver; Liver Cirrhosis | 1964 |
STUDIES ON FATTY LIVER INDUCTION BY 4-AMINOPYRAZOLOPYRIMIDINE.
Topics: Acetates; Antimetabolites; Carbon Isotopes; Cholesterol; Fatty Acids; Fatty Liver; Glycerides; Glyci | 1963 |
AN OROTIC ACID-INDUCED, ADENINE-REVEREED INHIBITION OF HEPATIC LIPOPROTEIN SECRETION IN THE RAT.
Topics: Adenine; Adipose Tissue; Antimetabolites; Cholesterol; Fatty Acids; Fatty Liver; Glycerides; Intesti | 1964 |
METABOLIC ASPECTS OF "OROTIC ACID FATTY LIVER". RELATIONSHIPS BETWEEN BIOTIN AND FATTY LIVER.
Topics: Biotin; Diet; Fatty Liver; Orotic Acid; Pharmacology; Rats; Research; Toxicology | 1964 |
PERIPORTAL FATTY LIVER IN THE RAT INDUCED BY HIGH PROTEIN OROTIC ACID DIETS.
Topics: Adenine; Diet; Dietary Proteins; Fatty Liver; Orotic Acid; Pharmacology; Rats; Research; Toxicology | 1964 |
OROTIC ACID-INDUCED FATTY LIVER. METABOLIC STUDIES IN CONVENTIONAL AND GERM-FREE RATS.
Topics: Diet; Fatty Liver; Feces; Germ-Free Life; Intestinal Absorption; Intestines; Metabolism; Nucleosides | 1965 |
TOTAL LIVER PROTEIN AND AMINO ACID INCORPORATION INTO LIVER PROTEIN IN OROTIC ACID-INDUCED FATTY LIVER.
Topics: Amino Acids; Carbon Isotopes; Fatty Liver; Glycine; Leucine; Orotic Acid; Pharmacology; Proteins; Ra | 1965 |
PATHOGENESIS OF OROTIC ACID-INDUCED FATTY CHANGE IN THE RAT LIVER: LIGHT AND ELECTRON MICROSCOPIC STUDIES.
Topics: Animals; Cell Physiological Phenomena; Electrons; Endoplasmic Reticulum; Fatty Liver; Lipid Metaboli | 1965 |
CHRONIC FATTY LIVER WITHOUT CIRRHOSIS INDUCED IN THE RAT BY DIETARY OROTIC ACID.
Topics: Diet; Fatty Liver; Histocytochemistry; Liver Cirrhosis; Organ Size; Orotic Acid; Pathology; Pharmaco | 1965 |
OROTIC ACID AND FATTY LIVERS.
Topics: Fatty Liver; Humans; Lipids; Orotic Acid; Rats | 1965 |
Fatty liver induction by orotic acid.
Topics: Fatty Liver; Humans; Liver Diseases; Orotic Acid | 1960 |
High-resolution diffusion and relaxation-edited magic angle spinning 1H NMR spectroscopy of intact liver tissue.
Topics: Animals; Fatty Liver; Liver; Magnetic Resonance Spectroscopy; Male; Orotic Acid; Rats; Rats, Sprague | 2003 |
An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver.
Topics: Administration, Oral; Animals; Fatty Acids; Fatty Liver; Gene Expression Profiling; Genomics; Kineti | 2004 |
Alleviation of fatty liver by alpha-linolenic acid.
Topics: alpha-Linolenic Acid; Animals; Fatty Liver; Linoleic Acid; Male; Organ Size; Orotic Acid; Phosphatid | 2004 |
Impaired microsomal oxidation of the atypical antipsychotic agent clozapine in hepatic steatosis.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; | 2007 |
Total inhibition of hepatic beta-lipoprotein production in the rat by orotic acid.
Topics: Animals; Blood Protein Electrophoresis; Fatty Liver; Immunoelectrophoresis; Lipoproteins; Liver; Oro | 1967 |
Effect of environmental temperature on fatty livers produced by various hepatotoxic agents in rats.
Topics: Animals; Carbon Tetrachloride; Choline; Diet; Ethanol; Ethionine; Fatty Liver; Female; Lipid Metabol | 1967 |
Increased lipoperoxide content of orotic acid-induced fatty liver.
Topics: Animals; Fatty Liver; In Vitro Techniques; Lipids; Liver; Orotic Acid; Peroxides; Rats | 1967 |
Biotin deficiency and orotic acid fatty liver in the rat.
Topics: Animals; Avitaminosis; Biotin; Body Weight; Diet; Fatty Liver; Female; Lipid Metabolism; Organ Size; | 1967 |
Ammonia detoxification in the fatty liver.
Topics: Acetates; Ammonium Chloride; Animals; Bicarbonates; Fatty Liver; In Vitro Techniques; Liver; Male; O | 1982 |
Fatty liver of growing rats fed excess lysine and its prevention by adenine or allopurinol.
Topics: Adenine; Allopurinol; Animals; Arginine; Diet; Fatty Liver; Lipid Metabolism; Liver; Lysine; Male; O | 1981 |
Reduction of beta-oxidation capacity of rat liver mitochondria by feeding orotic acid.
Topics: Acyl-CoA Dehydrogenases; Adenine; Animals; Clofibric Acid; Diet; Fatty Acids; Fatty Liver; Male; Mit | 1982 |
Impaired glycosylation in liver microsomes of orotic-acid-fed rats.
Topics: Animals; Fatty Liver; Fucose; Galactose; Hexosyltransferases; Kinetics; Male; Mannose; Microsomes, L | 1982 |
Species specificity of arginine deficiency-induced hepatic steatosis.
Topics: Age Factors; Animals; Arginine; Body Weight; Cricetinae; Disease Susceptibility; Fatty Liver; Lipid | 1981 |
Effect of l-ascorbate 2-sulfate on fatty liver and hyperlipidemia induced by various treatments in rats and guinea pigs.
Topics: Animals; Ascorbic Acid; Cholesterol; Ethionine; Fatty Liver; Female; Guinea Pigs; Hyperlipidemias; L | 1980 |
[Clinical experience report on Hepavis].
Topics: Adult; Aged; Alanine Transaminase; Aspartate Aminotransferases; Choline; Dehydrocholic Acid; Drug Co | 1980 |
Changes in activity levels and isozyme patterns of isoleucine aminotransferase in response to experimentally induced hepatic lesion.
Topics: Animals; Fatty Liver; Galactosamine; Isoenzymes; Male; Methionine Adenosyltransferase; Mitochondria, | 1995 |
[Animal experiment studies on the influence of fatty infiltration of liver cells on tissue relaxation times and signal changes in magnetic resonance tomography].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Clinical Enzyme Tests; Ethionine; Fatty | 1995 |
Long-term voluntary fasting in adult obese cats: nitrogen balance, plasma amino acid concentrations and urinary orotic acid excretion.
Topics: Amino Acids; Animals; Cat Diseases; Cats; Fasting; Fatty Liver; Female; Male; Nitrogen; Obesity; Oro | 1994 |
Nitrogen balance, plasma free amino acid concentrations and urinary orotic acid excretion during long-term fasting in cats.
Topics: Amino Acids, Essential; Animals; Bilirubin; Body Weight; Cat Diseases; Cats; Fasting; Fatty Liver; F | 1994 |
Influence of orotic acid and estrogen on hepatic lipid storage and secretion in the goose susceptible to liver steatosis.
Topics: Animal Feed; Animals; Body Weight; Estrogens; Fatty Liver; Geese; Lipids; Lipoproteins, VLDL; Liver; | 1994 |
Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
Topics: Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1997 |
Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats.
Topics: Animals; Diet; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Fatty Liver; Li | 1998 |
Prevention of orotic-acid-induced fatty liver in male rats by dehydroepiandrosterone and/or phenobarbital.
Topics: Analysis of Variance; Animals; Cells, Cultured; Dehydroepiandrosterone; Dietary Sucrose; Energy Inta | 1998 |
Preventive effects of dehydroepiandrosterone acetate on the fatty liver induced by orotic acid in male rats.
Topics: Animals; Clofibrate; Dehydroepiandrosterone; Diet; Fatty Liver; Hypolipidemic Agents; Liver; Male; M | 1998 |
Effects of oral administration of orotic acid on hepatic morphologic characteristics and serum biochemical variables in cats.
Topics: Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferas | 1999 |
Urinary orotic acid-to-creatinine ratios in cats with hepatic lipidosis.
Topics: Animals; Biomarkers; Cat Diseases; Cats; Chromatography, High Pressure Liquid; Creatinine; Fatty Liv | 1999 |
Down-regulation of rat hepatic microsomal cytochromes P-450 in microvesicular steatosis induced by orotic acid.
Topics: Androstenedione; Animals; Aryl Hydrocarbon Hydroxylases; Body Weight; Cytochrome P-450 CYP2C8; Cytoc | 1999 |
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline | 2002 |
Hepatic triglyceride lipases--effect of clofibrate and halofenate.
Topics: Animals; Clofibrate; Fatty Acids, Nonesterified; Fatty Liver; Glycolates; Halofenate; Hydrogen-Ion C | 1976 |
Effects of nutritional factors on the development of ethanol-induced fatty liver in KK and KK-Ay mice.
Topics: Age Factors; Animals; Caseins; Cottonseed Oil; Dietary Carbohydrates; Dose-Response Relationship, Dr | 1975 |
Absence of fatty livers in rhesus monkeys fed orotic acid.
Topics: Animals; Fatty Liver; Female; Haplorhini; Lipids; Liver; Macaca; Macaca mulatta; Male; Milk; Orotic | 1979 |
Effect of phospholipid on the release of beta-lipoprotein in orotic acid-induced fatty liver.
Topics: Animals; Fatty Liver; Female; In Vitro Techniques; Lipoproteins, LDL; Liver; Orotic Acid; Phospholip | 1975 |
Sex difference in the development of fatty liver by orotic acid.
Topics: Acetates; Animals; Fatty Liver; Female; Lipoproteins, LDL; Liver; Male; Methionine; Orotic Acid; Pho | 1975 |
Accumulation of nascent lipoproteins in rat hepatic golgi during induction of fatty liver by orotic acid.
Topics: Animals; Diet; Endoplasmic Reticulum; Fatty Liver; Female; Golgi Apparatus; Lipoproteins, VLDL; Live | 1977 |
3-Hydroxy-3-methylglutaric acid and orotic acid induced fatty liver in rats.
Topics: Animals; Cholesterol; Fatty Liver; Glutarates; Hydroxy Acids; Lipoproteins, LDL; Liver; Orotic Acid; | 1977 |
Mechanism for fatty liver induction in rats fed arginine deficient diets.
Topics: Adenine; Animals; Arginine; Body Weight; Cholesterol; Citrates; Fatty Liver; Female; Guanine; Lipid | 1979 |
Reversal of orotic acid-induced fatty liver in rats by clofibrate.
Topics: Animals; Apoproteins; Clofibrate; Endoplasmic Reticulum; Fatty Liver; Golgi Apparatus; Liver; Male; | 1977 |
The metabolism of steroids in the fatty liver induced by orotic acid feeding.
Topics: Androstane-3,17-diol; Androstenedione; Animals; Cholestanes; Cholestenones; Cholesterol; Eating; Fat | 1976 |
Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents.
Topics: Acetates; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease M | 1975 |
Biochemical and immunohistochemical analysis of orotic acid-induced fatty liver.
Topics: Animals; Fatty Liver; Glutathione Peroxidase; Immunohistochemistry; Lipid Peroxidation; Lipid Peroxi | 1991 |
Enzyme histochemical and ultrastructural approach in orotic acid-induced fatty liver and their recovery process in Wistar rats.
Topics: Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Cytoplasm; Endoplasmic Reticulum; Fatty Live | 1988 |
Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats.
Topics: Ammonium Chloride; Animals; Benzoates; Choline Deficiency; Diet; Fatty Liver; Gluconeogenesis; Hippu | 1989 |
Arginine needs, physiological state and usual diets. A reevaluation.
Topics: Animals; Arginine; Body Weight; Creatine; Diet; Fatty Liver; Female; Humans; Lysine; Nutritional Req | 1986 |
Apolipoproteins of the orotic acid fatty liver: implications for the biogenesis of plasma lipoproteins.
Topics: Animals; Apolipoproteins; Electrophoresis, Polyacrylamide Gel; Fatty Liver; Liposomes; Male; Orotic | 1988 |
Ultrasonic propagation properties (@ 100 MHz) in excessively fatty rat liver.
Topics: Animals; Dietary Fats; Fatty Liver; Female; Orotic Acid; Rats; Rats, Inbred Strains; Time Factors; U | 1988 |
The role of hepatic ornithine transcarbamylase deficiency in the orotic aciduria of pregnant mice.
Topics: Animals; Creatinine; Fatty Liver; Female; Genotype; Liver; Mice; Mice, Mutant Strains; Mitochondria, | 1986 |
Ultrastructural and enzyme histochemical studies in orotic acid-induced fatty liver.
Topics: Animals; Esterases; Fatty Liver; Histocytochemistry; Lipase; Liver; Male; Microscopy, Electron; Orot | 1986 |
[The treatment of hepatoses].
Topics: Biotransformation; Chemical and Drug Induced Liver Injury; Cholestasis; Diet Therapy; Fatty Liver; G | 1972 |
Orotic acid induced fatty liver and influence of papain.
Topics: Animals; Cholesterol; Depression, Chemical; Fatty Liver; Lipid Metabolism; Liver; Orotic Acid; Papai | 1970 |
Effect of glucosamine on orotic acid induced fatty liver.
Topics: Animals; Fatty Liver; Female; Glucosamine; Lipoproteins; Male; Nucleotides; Orotic Acid; Rats | 1971 |
[Effect of cholineorotate on experimental fatty liver in the rat].
Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Choline; Fatty Liver; Li | 1970 |
Effect of dietary orotic acid on liver glycogen.
Topics: Adenine; Animals; Epinephrine; Fatty Liver; Glucose-6-Phosphatase; Glucosidases; Glycine; In Vitro T | 1965 |
Changes in rat liver cells induced by orotic acid feeding.
Topics: Animals; Endoplasmic Reticulum; Fatty Liver; Golgi Apparatus; Liver; Microscopy, Electron; Orotic Ac | 1966 |
Effect of adrenal and hypophyseal hormones on the development of fatty liver in rats fed orotic acid.
Topics: Administration, Oral; Adrenal Glands; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Fatty Liv | 1972 |
The effect of (+)-catechin on the hepatic level of ATP and the lipid content of liver during experimental steatosis.
Topics: Adenosine Triphosphate; Animals; Catechin; Dietary Proteins; Ethanol; Ethionine; Fatty Liver; Female | 1972 |
Study of steatosis induced in the rat by orotic acid.
Topics: Animals; Cholesterol; Diet; Erythrocytes; Fatty Liver; Female; Lipoproteins, LDL; Liver; Organ Size; | 1973 |
Serum lipoprotein accumulation in the livers of orotic acid-fed rats.
Topics: Animals; Apoproteins; Cell Fractionation; Centrifugation, Zonal; Chylomicrons; Electrophoresis, Poly | 1971 |
Fatty livers induction by orotic acid contained in skim milk powder.
Topics: Animals; Body Weight; Diet; Eating; Fatty Liver; Female; Lipid Metabolism; Liver; Milk; Organ Size; | 1974 |
[Treatment of fatty liver].
Topics: Anabolic Agents; Dietary Carbohydrates; Fatty Liver; Humans; Liver Extracts; Orotic Acid; Vitamin B | 1974 |
Fatty liver induction: effect of ethionine on polyunsaturated fatty acid synthesis.
Topics: Acetates; Animals; Body Weight; Carbon Isotopes; Cytochrome P-450 Enzyme System; Edetic Acid; Ethion | 1973 |
Effect of nicotinic acid on serum & hepatic lipids in experimentally induced fatty liver.
Topics: Animals; Carbon Tetrachloride; Fatty Liver; Lipids; Liver; Male; Nicotinic Acids; Orotic Acid; Rats | 1972 |
Production of fatty liver with dietary ethanol despite orotic acid supplementation.
Topics: Alcohol Drinking; Animals; Body Weight; Diet; Disease Models, Animal; Ethanol; Fatty Liver; Liver; M | 1974 |
Production and prevention of fatty liver in rats fed clofibrate and orotic acid diets containing sucrose.
Topics: Animals; Apoproteins; Cholesterol; Clofibrate; Diet; Drug Synergism; Endoplasmic Reticulum; Fatty Li | 1974 |
Effect of clofibrate on the handling of dietary and liver fat.
Topics: Animals; Cholesterol; Clofibrate; Diet; Electrophoresis, Disc; Enzyme Activation; Fatty Liver; Gluco | 1972 |
A comparison of hypolipidemic drugs in the prevention of an orotic acid fatty liver.
Topics: Animals; Clofibrate; Diet; Electrophoresis; Ethylamines; Fatty Liver; Glucosephosphate Dehydrogenase | 1972 |
[Clinical experimentation with Aïcamine in hepatic insufficiency].
Topics: Adolescent; Adult; Aged; Carboxylic Acids; Fatty Liver; Female; Hepatitis; Humans; Imidazoles; Liver | 1972 |
Fatty liver induction: inverse relationship between hepatic neutral lipid accumulation and dietary polyunsaturated fatty acids in orotic acid-fed rats.
Topics: Aniline Compounds; Animals; Dietary Fats; Fatty Acids, Essential; Fatty Liver; Female; Hexobarbital; | 1972 |
The thiobarbituric acid reaction in relation to fatty livers.
Topics: Aldehydes; Animals; Barbiturates; Chromatography, Gas; Diet; Dietary Fats; Ethanol; Fatty Acids; Fat | 1971 |
Metabolic and histopathological consequences of a fatty liver during the acute stages of myocardial infarction in rats.
Topics: Acute Disease; Adrenal Glands; Alanine Transaminase; Aldosterone; Animals; Aspartate Aminotransferas | 1971 |
Effect of DPPD on the orotic acid-induced fatty liver in the rat.
Topics: Aldehydes; Aniline Compounds; Animals; Fatty Liver; Liver; Male; Malonates; Orotic Acid; Peroxides; | 1970 |
Studies on myoinositol. V. Effect of myoinositol on the prevention of fatty liver induced by orotic acid.
Topics: Animals; Choline; Fatty Liver; Injections, Subcutaneous; Inositol; Lipid Metabolism; Liver; Male; Mu | 1970 |
Influence of orotic acid on liver tumorigenesis in rats ingesting ethionine, N-2-fluorenylacetamide, and 3'-methyl-dimethylaminoazobenzene.
Topics: Acetamides; Acetates; Amides; Animals; Azo Compounds; Benzene Derivatives; Body Weight; Diet; Diseas | 1970 |
[Biochemical mechanisms of steatosis as sequelae of "nucleotide imbalance"].
Topics: Acetates; Adenine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Azaserine; Biotin; Carbon I | 1970 |
Prevention of orotic acid-induced fatty liver with allopurinol.
Topics: Allopurinol; Animals; Fatty Liver; Liver; Nucleotides; Orotic Acid; Rats | 1971 |
Protection by orotic acid against the renal necrosis and fatty liver of choline deficiency.
Topics: Adenine; Animals; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Male; Necrosis; Orotic | 1968 |
[Apropos of the pathogenesis of acute alcoholic steatosis of the liver].
Topics: Adenosine Triphosphate; Alcoholism; Animals; Biotin; Carbon Isotopes; Ethanol; Ethionine; Fatty Live | 1968 |
The metabolism of short and long chain fatty acids in orotic acid-fed rats.
Topics: Abetalipoproteinemia; Animals; Carbon Isotopes; Chylomicrons; Diet; Fatty Acids; Fatty Liver; Female | 1969 |
Isolation and characterization of low density structures from orotic acid-induced fatty livers.
Topics: Adenine; Animals; Carbon Isotopes; Centrifugation, Density Gradient; Endoplasmic Reticulum; Fatty Li | 1969 |
Studies on orotic acid fatty liver in rats: factors influencing the induction of fatty liver.
Topics: Adenosine Triphosphate; Animals; Depression, Chemical; Diet; Esters; Fasting; Fatty Liver; Female; F | 1969 |
Hepatic ATP and triglyceride levels in choline-deficient rats with and without dietary orotic acid supplementation.
Topics: Adenine; Adenosine Triphosphate; Animals; Choline Deficiency; Diet; Dietary Fats; Fatty Liver; Liver | 1969 |
Vitamin E and hepatotoxic agents. 2. Lipid peroxidation and poisoning with orotic acid, ethanol and thioacetamide in rats.
Topics: Aldehydes; Amides; Aniline Compounds; Animals; Ethanol; Fatty Liver; In Vitro Techniques; Lipid Meta | 1969 |
[Lipid metabolism in orotic acid-induced fatty liver].
Topics: Animals; Chromatography, Thin Layer; Fatty Liver; Lipid Metabolism; Liver; Male; Orotic Acid; Rats; | 1969 |
Effect of orotic acid on the lipid and acid-soluble nucleotide concentrations in avian liver.
Topics: Animals; Chickens; Depression, Chemical; Diet; Fatty Liver; Lipids; Liver; Male; Nucleotides; Orotic | 1969 |
Metabolic aspects of "orotic acid fatty liver". Nucleotide control mechanisms of lipid metabolism.
Topics: Adenine; Aminohydrolases; Animals; DNA; Fatty Liver; Lipid Metabolism; Nucleotides; Orotic Acid; Pho | 1964 |
The mechanism of inhibition of lipoprotein synthesis by orotic acid.
Topics: Animals; Cholesterol; Dietary Fats; Fatty Liver; Lipoproteins; Orotic Acid; Perfusion; Rats | 1965 |
Alterations of lipoprotein metabolism in orotic acid-induced fatty liver.
Topics: Amino Acids; Animals; Fatty Liver; In Vitro Techniques; Lipoproteins; Orotic Acid; Perfusion; Rats | 1966 |
Fatty cirrhosis in the rat.
Topics: Animals; Autoradiography; Bile Ducts; Bile Ducts, Intrahepatic; Carbon Tetrachloride; Choline; Fats; | 1966 |
[Effects and side-effects of orotic acid].
Topics: Adenine; Animals; Drug Synergism; Fatty Liver; Galactosemias; Nucleotides; Orotic Acid; Purines; Rat | 1966 |