orotic acid has been researched along with Leukemia in 12 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HANDSCHUMACHER, RE | 2 |
| WEISSMAN, S | 1 |
| EISEN, AZ | 1 |
| KARON, M | 2 |
| LEWIS, M | 1 |
| WEISSMAN, SM | 1 |
| BUTTOO, AS | 1 |
| ISRAUELS, MC | 1 |
| WILKINSON, JF | 1 |
| SATO, K | 1 |
| LEPAGE, GA | 1 |
| Cleaveland, ES | 1 |
| Zaharevitz, DW | 1 |
| Kelley, JA | 1 |
| Paull, K | 1 |
| Cooney, DA | 1 |
| Ford, H | 1 |
| Cadman, E | 1 |
| Eiferman, F | 1 |
| Heimer, R | 1 |
| Davis, L | 1 |
| Reyes, P | 1 |
| Brooke, J | 1 |
| Szabados, E | 1 |
| Lyons, SD | 1 |
| Goodridge, RJ | 1 |
| Harsanyi, MC | 1 |
| Poiner, A | 1 |
| Christopherson, RI | 1 |
| Castoldi, GL | 1 |
| Yam, LT | 1 |
| Mitus, WJ | 1 |
| Vogler, WR | 1 |
| Bain, JA | 1 |
| Huguley, CM | 1 |
12 other studies available for orotic acid and Leukemia
| Article | Year |
|---|---|
5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides.
Topics: Antimetabolites; Leukemia; Leukemia, Experimental; Liver; Orotic Acid; Pyrimidine Nucleotides; Uraci | 1963 |
Pseudouridine metabolism. II. Urinary excretion in gout, psoriasis, leukemia, and heterozygous oroticaciduria.
Topics: Gout; Humans; Leukemia; Nucleosides; Nucleotides; Orotate Phosphoribosyltransferase; Orotic Acid; Or | 1962 |
STUDIES ON THE PSEUDOURIDINIURIA OF CHRONIC LYMPHOCYTIC LEUKEMIA.
Topics: Body Fluids; Carbon Isotopes; Fluids and Secretions; Humans; Leukemia; Leukemia, Lymphocytic, Chroni | 1964 |
HYPOCHOLESTEROLAEMIA AND OROTIC ACIDURIA DURING TREATMENT WITH 6-AZAURIDINE.
Topics: Antineoplastic Agents; Azauridine; Cholesterol; Drug Therapy; Leukemia; Leukocyte Count; Lymphoma; L | 1965 |
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolis | 1964 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla | 1965 |
Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar.
Topics: Antineoplastic Agents; Aspartic Acid; Biphenyl Compounds; Breast Neoplasms; Carbolines; Carcinoma, N | 1996 |
Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Azacitidine; Cell Survival; Drug Synergism; Drug Thera | 1978 |
The rapid separation of orotate, orotidylate, and uridylate by thin-layer chromatography. Utility in the assay of orotate phosphoribosyltransferase and orotidylate decarboxylase.
Topics: Chromatography, Thin Layer; Leukemia; Liver; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidi | 1977 |
Cytotoxic effects of dihydroorotase inhibitors upon human CCRF-CEM leukemia.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cell Survival; Dihydroorotase; DNA, Neoplasm; Humans; | 1990 |
Cytochemical demonstration of dihydroorotic dehydrogenase in blood and bone marrow cells.
Topics: Anemia, Aplastic; Blood Cell Count; Blood Platelets; Bone Marrow; Bone Marrow Cells; Cytoplasmic Gra | 1968 |
In vivo effect of hydroxyurea on orotic acid synthesis.
Topics: Adult; Aged; Antimetabolites; DNA; Humans; Leukemia; Melanoma; Middle Aged; Nucleosides; Orotic Acid | 1966 |