orotic acid has been researched along with Leukemia L 1210 in 16 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deazauridine treatment of L1210 cells in culture stimulated the uptake of deoxycytidine-3H into DNA while inhibiting the uptake of 3H-labeled deoxyuridine, thymidine, deoxyadenosine, and deoxyguanosine." | 1.25 | The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine. ( Brockman, RW; Nelson, JA; Rose, LM; Schabel, FM; Shaddix, SC; Williams, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (62.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BONO, VH | 1 |
| CHENG, CC | 1 |
| FREI, E | 1 |
| KELLY, MG | 1 |
| Okada, J | 1 |
| Nakano, K | 1 |
| Miyake, H | 1 |
| Loh, E | 1 |
| Kufe, DW | 1 |
| Grzelkowska, K | 1 |
| Motyl, T | 1 |
| Malicka, E | 1 |
| Ostrowski, J | 1 |
| Trzeciak, L | 1 |
| Filipecki, M | 1 |
| Shopova, M | 1 |
| Tabakova, S | 1 |
| Taxirov, S | 1 |
| Golovinsky, E | 1 |
| Beuneu, C | 1 |
| Auger, R | 1 |
| Löffler, M | 1 |
| Guissani, A | 1 |
| Lemaire, G | 1 |
| Lepoivre, M | 1 |
| Brockman, RW | 1 |
| Shaddix, SC | 1 |
| Williams, M | 1 |
| Nelson, JA | 1 |
| Rose, LM | 1 |
| Schabel, FM | 1 |
| Moyer, JD | 1 |
| Handschumacher, RE | 1 |
| Chen, SF | 1 |
| Perrella, FW | 1 |
| Behrens, DL | 1 |
| Papp, LM | 1 |
| Brooke, J | 1 |
| Szabados, E | 1 |
| Lyons, SD | 1 |
| Goodridge, RJ | 1 |
| Harsanyi, MC | 1 |
| Poiner, A | 1 |
| Christopherson, RI | 1 |
| Castan, P | 1 |
| Colacio-Rodriguez, E | 1 |
| Beauchamp, AL | 1 |
| Cros, S | 1 |
| Wimmer, S | 1 |
| Peters, GJ | 1 |
| Sharma, SL | 1 |
| Laurensse, E | 1 |
| Pinedo, HM | 1 |
| Mishra, LC | 2 |
| Mead, JA | 2 |
| Danielsson, B | 1 |
| Bogentoft, C | 1 |
| Ljungnér, F | 1 |
| Sartorelli, AC | 1 |
| Booth, BA | 1 |
16 other studies available for orotic acid and Leukemia L 1210
| Article | Year |
|---|---|
MEHTYL-5-FLUOROOROTATE: SYNTHESIS AND COMPARISON WITH 5-FLUOROOROTIC ACID WITH RESPECT TO BIOLOGICAL ACTIVITY AND CELL ENTRY.
Topics: Animals; Leukemia L1210; Leukocytes; Metabolism; Mice; Orotic Acid; Research | 1964 |
Uracil derivatives. IV. Growth-inhibitory activity against L-1210 cells of orotic acid derivatives and synthesis of 1-(beta-D-ribofuranosyl)furo[3,4-d]pyrimidine-2,4,7(1H,3H,5H)-trione.
Topics: Animals; Antineoplastic Agents; Leukemia L1210; Mice; Orotic Acid; Pyrimidine Nucleosides | 1983 |
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleot | 1981 |
Effect of orotic acid on TGF-beta 1-induced growth inhibition of L1210 leukemic cells.
Topics: Animals; Cell Division; Leukemia L1210; Mice; Orotic Acid; Transforming Growth Factor beta; Tumor Ce | 1995 |
Synthesis and biological activity of some N1-substituted orotic acids.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Chromatography, Thin Layer; Drug Sc | 1993 |
Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide.
Topics: Animals; Antioxidants; Ascorbic Acid; Digitonin; Dihydroorotate Dehydrogenase; Electron Transport; E | 2000 |
The mechanism of action of 3-deazauridine in tumor cells sensitive and resistant to arabinosylcytosine.
Topics: 3-Deazauridine; Adenocarcinoma; Animals; Cell Line; Cytarabine; Deoxycytidine; Deoxyribonucleotides; | 1975 |
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Female; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred | 1979 |
Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Dehydrogenase; Kinetics; Leukemia | 1992 |
Cytotoxic effects of dihydroorotase inhibitors upon human CCRF-CEM leukemia.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cell Survival; Dihydroorotase; DNA, Neoplasm; Humans; | 1990 |
Platinum and palladium complexes of 3-methyl orotic acid: a route toward palladium complexes with good antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Survival; Crystallography; Female; Leukemia L1210; Mice; Models | 1990 |
Inhibition of pyrimidine de novo synthesis by DUP-785 (NSC 368390).
Topics: Amides; Animals; Antineoplastic Agents; Biphenyl Compounds; Dihydroorotate Oxidase; Leukemia L1210; | 1987 |
On the biochemical mechanism of action of tetrahydrohomofolic acid.
Topics: Animals; Carbon Isotopes; Cell Line; Deoxyuridine; Depression, Chemical; DNA; Drug Resistance; Folic | 1972 |
Effect of tetrahydrohomofolate on DNA biosynthesis in leukemic mice.
Topics: Animals; Carbon Isotopes; DNA; Folic Acid; Formates; Kidney; Leukemia L1210; Liver; Male; Mice; Mice | 1971 |
Potential anticancer agents. I. A nitrogen mustard based on orotic acid.
Topics: Animals; Antimetabolites; Esters; Leukemia L1210; Mice; Neoplasms, Experimental; Nitrogen Mustard Co | 1968 |
The synergistic anti-neoplastic activity of combinations of mitomycins with either 6-thioguanine or 5-fluorouracil.
Topics: Animals; Antineoplastic Agents; DNA, Neoplasm; Drug Synergism; Female; Fluorouracil; In Vitro Techni | 1965 |