orotic acid has been researched along with Hypertension in 11 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The use of antihypertensive, metabolic (magnesium orotate) drugs, sedative and uroseptic phytotherapy, application of other nondrug measures in conditions of multidisciplinary dynamic support of the gestational period facilitated regress of clinical symptoms of EHT and EHT+CTD, favorable course of pregnancy and successful delivery." | 9.17 | [Magnesium orotate in treatment of chronic hypertension in pregnant women]. ( Gaĭsin, IR; Iskhakova, AS; Khodyrev, LA; Maksimov, NI; Shilina, LV; Valeeva, RM, 2013) |
| "Our objective was to study the urinary levels of orotic acid in normal pregnancy and in pregnancy-induced hypertension." | 7.70 | Urinary orotic acid levels in normal pregnancy and pregnancy-induced hypertension. ( Furutani, K; Ito, M; Matsubara, K; Ochi, H; Togari, H, 2000) |
| "Orotic acid (OA) is an intermediate of pyrimidine nucleotide biosynthesis." | 5.42 | Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. ( Choi, YJ; Kang, KW; Kang, YP; Kwon, SW; Lee, BH; Lee, KY; Lee, SM; Lim, DK; Yoon, Y, 2015) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 5.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| " The use of antihypertensive, metabolic (magnesium orotate) drugs, sedative and uroseptic phytotherapy, application of other nondrug measures in conditions of multidisciplinary dynamic support of the gestational period facilitated regress of clinical symptoms of EHT and EHT+CTD, favorable course of pregnancy and successful delivery." | 5.17 | [Magnesium orotate in treatment of chronic hypertension in pregnant women]. ( Gaĭsin, IR; Iskhakova, AS; Khodyrev, LA; Maksimov, NI; Shilina, LV; Valeeva, RM, 2013) |
| "Our objective was to study the urinary levels of orotic acid in normal pregnancy and in pregnancy-induced hypertension." | 3.70 | Urinary orotic acid levels in normal pregnancy and pregnancy-induced hypertension. ( Furutani, K; Ito, M; Matsubara, K; Ochi, H; Togari, H, 2000) |
| "Orotic acid (OA) is an intermediate of pyrimidine nucleotide biosynthesis." | 1.42 | Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis. ( Choi, YJ; Kang, KW; Kang, YP; Kwon, SW; Lee, BH; Lee, KY; Lee, SM; Lim, DK; Yoon, Y, 2015) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 1.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (27.27) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gaĭsin, IR | 1 |
| Valeeva, RM | 1 |
| Maksimov, NI | 1 |
| Iskhakova, AS | 1 |
| Khodyrev, LA | 1 |
| Shilina, LV | 1 |
| Choi, YJ | 1 |
| Yoon, Y | 1 |
| Lee, KY | 1 |
| Kang, YP | 1 |
| Lim, DK | 1 |
| Kwon, SW | 1 |
| Kang, KW | 1 |
| Lee, SM | 1 |
| Lee, BH | 1 |
| Martynov, AI | 1 |
| Akatova, EV | 1 |
| Classen, HG | 1 |
| Choi, SM | 1 |
| Kim, JE | 1 |
| Ahn, BO | 1 |
| Kwon, JW | 1 |
| Hadj, A | 1 |
| Pepe, S | 1 |
| Rosenfeldt, F | 1 |
| Wakabayashi, Y | 1 |
| Yamada, E | 1 |
| Yoshida, T | 1 |
| Takahashi, H | 1 |
| Furutani, K | 1 |
| Ochi, H | 1 |
| Matsubara, K | 1 |
| Ito, M | 1 |
| Togari, H | 1 |
| Zharov, EI | 1 |
| Szelényi, I | 1 |
| Sós, J | 1 |
| Rigó, J | 1 |
| Meerson, FZ | 1 |
| Bykovskaia, KN | 1 |
2 reviews available for orotic acid and Hypertension
| Article | Year |
|---|---|
Magnesium orotate--experimental and clinical evidence.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Biological Availability; Clinical Trials as Topic; H | 2004 |
The clinical application of metabolic therapy for cardiovascular disease.
Topics: Adaptation, Physiological; Cardiovascular Diseases; Coenzymes; Exercise; Glucose; Heart Failure; Hum | 2007 |
1 trial available for orotic acid and Hypertension
| Article | Year |
|---|---|
[Magnesium orotate in treatment of chronic hypertension in pregnant women].
Topics: Adult; Antihypertensive Agents; Blood Pressure; Connective Tissue Diseases; Dietary Supplements; Dru | 2013 |
8 other studies available for orotic acid and Hypertension
| Article | Year |
|---|---|
Orotic acid induces hypertension associated with impaired endothelial nitric oxide synthesis.
Topics: Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Insulin; Metformin; Nitric Oxide; Nitr | 2015 |
[Fifteen years experience of the use of magnesium preparations in patients with mitral valve prolapse].
Topics: Adult; Autonomic Nervous System; Blood Pressure; Drug Administration Schedule; Drug Monitoring; Echo | 2011 |
Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium; Cardiomegaly; Ce | 2006 |
Deficiency of endogenous arginine synthesis provokes hypertension by exhausting substrate arginine for nitric oxide synthesis.
Topics: Amino Acids; Animals; Arginine; Blood Pressure; Creatinine; Cyclic GMP; Eating; Hypertension; Intest | 1994 |
Urinary orotic acid levels in normal pregnancy and pregnancy-induced hypertension.
Topics: Arginine; Female; Gestational Age; Humans; Hypertension; Nitric Oxide; Orotic Acid; Pregnancy; Pregn | 2000 |
[Use of cofactors of the synthesis and precursors of nucleic acids in myocardial infarct patients].
Topics: Blood Circulation Time; Blood Pressure; Cardiac Output; Female; Folic Acid; Humans; Hypertension; Ma | 1971 |
[Effect of magnesium orotate and orotic acid on induced blood pressure elevation and cardiopathogenic changes of the myocardium in animal experiments].
Topics: Animals; Blood Pressure; Heart; Heart Diseases; Hypertension; Magnesium; Male; Myocardium; Orotic Ac | 1970 |
[Antihypertensive effect of cofactors of synthesis and precursors of nucleic acids in experimental salt hypertension].
Topics: Animals; Blood Pressure; Folic Acid; Hypertension; Injections, Intramuscular; Methods; Nucleic Acids | 1967 |