orotic acid has been researched along with Heart Failure in 14 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication." | 9.14 | Magnesium orotate in severe congestive heart failure (MACH). ( Martynow, AI; Stepura, OB, 2009) |
| "Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication." | 9.14 | Magnesium orotate in severe congestive heart failure (MACH). ( Martynow, AI; Stepura, OB, 2009) |
| "Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication." | 5.14 | Magnesium orotate in severe congestive heart failure (MACH). ( Martynow, AI; Stepura, OB, 2009) |
| "Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication." | 5.14 | Magnesium orotate in severe congestive heart failure (MACH). ( Martynow, AI; Stepura, OB, 2009) |
| " A subset of metabolite-HF associations was independent of well-established HF pathways such as increased left ventricular mass index and incident coronary heart disease and included homoarginine (per 1 SD increase in metabolite level, hazard ratio, 0." | 4.02 | Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study. ( Andersson, C; Benson, MD; Chen, ZZ; Clish, CB; Correa, A; Cruz, DE; Dailey, L; Gao, Y; Gerszten, RE; Hall, ME; Katz, DH; Ngo, D; Peterson, B; Robbins, JM; Shen, C; Shi, X; Tahir, UA; Vasan, RS; Wang, TJ; Wilson, JG; Zhao, T, 2021) |
| "This study deals with the potential therapeutic effect of orotic acid (OA) and Mg Orotate (MgO) on myocardial degeneration and the development of congestive heart failure in cardiomyopathic (CM) hamsters of the UM-X7." | 3.70 | Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy. ( Jasmin, G; Proschek, L, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Tahir, UA | 1 |
| Katz, DH | 1 |
| Zhao, T | 1 |
| Ngo, D | 1 |
| Cruz, DE | 1 |
| Robbins, JM | 1 |
| Chen, ZZ | 1 |
| Peterson, B | 1 |
| Benson, MD | 1 |
| Shi, X | 1 |
| Dailey, L | 1 |
| Andersson, C | 1 |
| Vasan, RS | 1 |
| Gao, Y | 1 |
| Shen, C | 1 |
| Correa, A | 1 |
| Hall, ME | 1 |
| Wang, TJ | 1 |
| Clish, CB | 1 |
| Wilson, JG | 1 |
| Gerszten, RE | 1 |
| Stepura, OB | 2 |
| Martynow, AI | 2 |
| SEITZ, K | 1 |
| Classen, HG | 1 |
| Hadj, A | 1 |
| Pepe, S | 1 |
| Rosenfeldt, F | 1 |
| Geiss, KR | 1 |
| Stergiou, N | 1 |
| Neuenfeld, HU | 1 |
| Jester, HG | 1 |
| Jasmin, G | 1 |
| Proschek, L | 1 |
| Simonson, E | 1 |
| Berman, R | 1 |
| Masliuk, VI | 1 |
| Popov, VG | 1 |
| Popova, TA | 1 |
| Litvintsev, VP | 1 |
| Wexler, BC | 1 |
| Judd, JT | 1 |
| Lutmer, RF | 1 |
| Saroff, J | 1 |
| Bajusz, E | 3 |
| Homburger, F | 1 |
| Baker, JR | 1 |
| Bogdonoff, P | 1 |
3 reviews available for orotic acid and Heart Failure
| Article | Year |
|---|---|
Magnesium orotate--experimental and clinical evidence.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Biological Availability; Clinical Trials as Topic; H | 2004 |
The clinical application of metabolic therapy for cardiovascular disease.
Topics: Adaptation, Physiological; Cardiovascular Diseases; Coenzymes; Exercise; Glucose; Heart Failure; Hum | 2007 |
New approach in treatment of cardiac decompensation in U.S.S.R.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acids; Aortic Valve Stenosis; Cardiac Glyco | 1973 |
3 trials available for orotic acid and Heart Failure
| Article | Year |
|---|---|
Magnesium orotate in severe congestive heart failure (MACH).
Topics: Adult; Aged; Chemotherapy, Adjuvant; Female; Heart Failure; Humans; Male; Middle Aged; Orotic Acid; | 2009 |
Magnesium orotate in severe congestive heart failure (MACH).
Topics: Adult; Aged; Double-Blind Method; Female; Heart Failure; Humans; Male; Middle Aged; Orotic Acid; Pro | 2009 |
Effects of magnesium orotate on exercise tolerance in patients with coronary heart disease.
Topics: Coronary Disease; Double-Blind Method; Echocardiography; Exercise; Heart Failure; Humans; Myocardial | 1998 |
8 other studies available for orotic acid and Heart Failure
| Article | Year |
|---|---|
Metabolomic Profiles and Heart Failure Risk in Black Adults: Insights From the Jackson Heart Study.
Topics: Adult; Aged; Black or African American; Case-Control Studies; Collagen; Coronary Disease; Effect Mod | 2021 |
[ON THE INFLUENCE OF CARDIAC INSUFFICIENCY ON THE LIVER--THERAPEUTIC CONSEQUENCES].
Topics: Heart Failure; Humans; Hypoxia; Liver Diseases; Liver Function Tests; Orotic Acid | 1963 |
Effect of orotic acid and magnesium orotate on the development and progression of the UM-X7.1 hamster hereditary cardiomyopathy.
Topics: Animals; Body Weight; Calcinosis; Cardiomyopathies; Cricetinae; Diet; Electrocardiography; Female; H | 1998 |
[Treatment of cardiac insufficiency with cardiac glycosides in a complex with preparations effecting nucleic acid synthesis and energy formation].
Topics: Adenosine Triphosphate; Calcium; Cardiac Glycosides; Electrocardiography; Heart; Heart Failure; Huma | 1972 |
Metabolic and histopathological consequences of a fatty liver during the acute stages of myocardial infarction in rats.
Topics: Acute Disease; Adrenal Glands; Alanine Transaminase; Aldosterone; Animals; Aspartate Aminotransferas | 1971 |
Dissociation of factors influencing myocardial degeneration and generalized cardiocirculatory failure.
Topics: Animals; Aspartic Acid; Cricetinae; Diet; Digitoxin; Disease Models, Animal; Edema; Epinephrine; Fem | 1969 |
Enhanced healing of myocardial lesions and prevention of congestive heart failure. Experimental studies on the therapeutic effect of K-salts, alone and in combination with glucose and insulin, in a hereditary cardiomyopathy.
Topics: Animals; Aspartic Acid; Cardiomyopathies; Chronic Disease; Citrates; Connective Tissue; Cricetinae; | 1969 |
Interrelationships between reparative processes in myocardium and the development of congestive heart failure.
Topics: Animals; Aspartic Acid; Cardiomyopathies; Cricetinae; Genes, Recessive; Glucose; Heart Failure; Inbr | 1968 |