orotic acid has been researched along with Fatty Liver, Nonalcoholic in 11 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance." | 7.83 | Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats. ( Gao, X; Han, X; Liu, C; Wang, J; Wang, Y; Xue, C; Xue, Y; Yanagita, T, 2016) |
| "Orotic acid (OA) has been intensively utilized to induce fatty liver in rats." | 5.56 | Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. ( Käkelä, R; Matilainen, J; Mustonen, AM; Nieminen, P; Rilla, K; Sihvo, SP, 2020) |
| " The results showed that RO, rosmarinic acid (RA) and carnosic acid (CA) significantly reduced the contents of liver triglyceride (TG), total cholesterol (TC), free fatty acids (FFA) and improved cell hypertrophy, vacuolation, and cell necrosis in the liver of orotic acid induced non-alcoholic fatty liver disease (NAFLD) model rats." | 3.91 | Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats. ( Chen, Q; Liu, MY; Wang, SJ; Wang, T; Wu, JQ; Xu, JQ; Yu, HY; Zhang, Y, 2019) |
| "Preliminary study results have shown that rats with non-alcoholic fatty liver disease (NAFLD) induced by 1% orotic acid-containing diet have decreased hepatic CYP2D activity." | 3.91 | Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats. ( Bang, WS; Hwang, YR; Kang, HE; Lee, I; Li, Z, 2019) |
| "We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance." | 3.83 | Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats. ( Gao, X; Han, X; Liu, C; Wang, J; Wang, Y; Xue, C; Xue, Y; Yanagita, T, 2016) |
| " The fatty liver model was established by administration of 1% orotic acid (OA) to the rats." | 3.78 | Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. ( Hu, X; Li, Z; Wang, J; Wang, Y; Xu, J; Xue, C; Xue, Y; Yanagita, T; Zhang, B, 2012) |
| " We also investigated the anti-fatty liver activity of AMC-2 in rats with fatty liver induced by orotic acid." | 3.77 | Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides. ( Feng, TY; Sugawara, T; Wang, YM; Xu, J; Xue, CH; Zhang, B, 2011) |
| " Moreover, though the lipid-lowering effect of EA2 was not equal with EA at the same dosage of 0." | 1.72 | Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats. ( Li, X; Li, Z; Wang, Y; Wen, L; Xue, C; Zeng, B; Zhang, T; Zhao, Y, 2022) |
| "Orotic acid (OA) has been intensively utilized to induce fatty liver in rats." | 1.56 | Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. ( Käkelä, R; Matilainen, J; Mustonen, AM; Nieminen, P; Rilla, K; Sihvo, SP, 2020) |
| "Nonalcoholic fatty liver disease (NAFLD) has become one predictive factor of death from various illnesses." | 1.48 | Comparative Analysis of EPA/DHA-PL Forage and Liposomes in Orotic Acid-Induced Nonalcoholic Fatty Liver Rats and Their Related Mechanisms. ( Chang, M; Han, X; Tang, Q; Wang, Y; Xu, J; Xue, C; Yanagita, T; Zhang, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Zeng, B | 1 |
| Wen, L | 1 |
| Zhao, Y | 1 |
| Li, Z | 3 |
| Xue, C | 5 |
| Zhang, T | 2 |
| Wang, Y | 4 |
| Wang, SJ | 1 |
| Chen, Q | 2 |
| Liu, MY | 1 |
| Yu, HY | 1 |
| Xu, JQ | 1 |
| Wu, JQ | 1 |
| Zhang, Y | 2 |
| Wang, T | 2 |
| Matilainen, J | 1 |
| Mustonen, AM | 1 |
| Rilla, K | 1 |
| Käkelä, R | 1 |
| Sihvo, SP | 1 |
| Nieminen, P | 1 |
| Hu, Y | 1 |
| Xu, J | 5 |
| Liu, M | 1 |
| Wang, S | 1 |
| Yu, H | 1 |
| Jiang, Z | 1 |
| Kimura, Y | 1 |
| Shirouchi, B | 1 |
| Tanaka, Y | 1 |
| Tsai, WT | 1 |
| Yuan, X | 1 |
| Sato, M | 1 |
| Chang, M | 1 |
| Han, X | 2 |
| Tang, Q | 1 |
| Yanagita, T | 3 |
| Bang, WS | 1 |
| Hwang, YR | 1 |
| Lee, I | 1 |
| Kang, HE | 1 |
| Liu, C | 1 |
| Xue, Y | 2 |
| Wang, J | 3 |
| Gao, X | 1 |
| Liu, Y | 2 |
| Shi, D | 1 |
| Tian, Y | 1 |
| Zhan, Q | 1 |
| Wang, YM | 1 |
| Feng, TY | 1 |
| Zhang, B | 2 |
| Sugawara, T | 1 |
| Xue, CH | 1 |
| Hu, X | 1 |
11 other studies available for orotic acid and Fatty Liver, Nonalcoholic
| Article | Year |
|---|---|
Sea Cucumber Saponins Derivatives Alleviate Hepatic Lipid Accumulation Effectively in Fatty Acids-Induced HepG2 Cells and Orotic Acid-Induced Rats.
Topics: Animals; Cholesterol; Fatty Acids; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Non-alcoholic Fatt | 2022 |
Regulation effects of rosemary (Rosmarinus officinalis Linn.) on hepatic lipid metabolism in OA induced NAFLD rats.
Topics: Abietanes; Animals; Cinnamates; Depsides; Hep G2 Cells; Humans; Lipid Metabolism; Male; Non-alcoholi | 2019 |
Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism.
Topics: Carcinoma, Hepatocellular; Discriminant Analysis; Fatty Acids; Gene Expression Regulation, Neoplasti | 2020 |
Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats.
Topics: Animals; China; Cholesterol; Disease Models, Animal; Down-Regulation; Flavonoids; Hep G2 Cells; Huma | 2020 |
Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression.
Topics: Animals; Carrier Proteins; Diet; Egg Proteins, Dietary; Liver; Male; Non-alcoholic Fatty Liver Disea | 2021 |
Comparative Analysis of EPA/DHA-PL Forage and Liposomes in Orotic Acid-Induced Nonalcoholic Fatty Liver Rats and Their Related Mechanisms.
Topics: Animals; Aspartate Aminotransferases; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Liposome | 2018 |
Effects of Orotic Acid-Induced Non-Alcoholic Fatty Liver on the Pharmacokinetics of Metoprolol and its Metabolites in Rats.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Cytochrome P450 Family 2; Liver; Male; Metoprolol; | 2019 |
Long-term fatty liver-induced insulin resistance in orotic acid-induced nonalcoholic fatty liver rats.
Topics: Animals; Gene Expression; Gluconeogenesis; Glucose Tolerance Test; Insulin; Insulin Resistance; Male | 2016 |
Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease.
Topics: Animals; Carrier Proteins; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Disease Models, Animal; Eic | 2017 |
Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides.
Topics: Administration, Oral; Animals; Cerebrosides; Cholesterol; Fatty Acids; Fatty Liver; Gas Chromatograp | 2011 |
Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats.
Topics: Animals; Antimetabolites; Carnitine O-Palmitoyltransferase; Carrier Proteins; Cerebrosides; Dietary | 2012 |