orotic acid has been researched along with Experimental Leukemia in 13 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| HANDSCHUMACHER, RE | 4 |
| SATO, K | 1 |
| LEPAGE, GA | 1 |
| Cadman, E | 1 |
| Eiferman, F | 1 |
| Heimer, R | 1 |
| Davis, L | 1 |
| Cadman, EC | 1 |
| Dix, DE | 1 |
| Schwartz, PM | 1 |
| Krooth, RS | 1 |
| Hsiao, WL | 1 |
| Potvin, BW | 1 |
| Reyes, P | 2 |
| Guganig, ME | 1 |
| Guganig, M | 1 |
| Meĭren, DV | 1 |
| Belousova, AK | 1 |
| Kisseljov, FL | 1 |
| Semjonova, LA | 1 |
| Irlin, IS | 1 |
| Shatalova, GG | 1 |
| Veselý, J | 2 |
| Cihák, A | 2 |
| Sorm, F | 2 |
13 other studies available for orotic acid and Experimental Leukemia
| Article | Year |
|---|---|
5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides.
Topics: Antimetabolites; Leukemia; Leukemia, Experimental; Liver; Orotic Acid; Pyrimidine Nucleotides; Uraci | 1963 |
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolis | 1964 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla | 1965 |
Pyrazofurin enhancement of 5-azacytidine antitumor activity in L5178Y and human leukemia cells.
Topics: Amides; Animals; Antibiotics, Antineoplastic; Azacitidine; Cell Survival; Drug Synergism; Drug Thera | 1978 |
Clinical, biological, and biochemical effect of pyrazofurin.
Topics: Adolescent; Adult; Aged; Amides; Animals; Carcinoma 256, Walker; Cell Division; Cell Line; Female; H | 1978 |
Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro.
Topics: Allopurinol; Animals; Cell Line; Cell Survival; Drug Therapy, Combination; Fluorouracil; Humans; Leu | 1979 |
Resistance to 5-fluoroorotic acid and pyrimidine auxotrophy: a new bidirectional selective system for mammalian cells.
Topics: Animals; Clone Cells; Culture Media; Drug Resistance; Leukemia, Experimental; Mice; Orotic Acid; Phe | 1979 |
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Carboxylic Acids; Cells, Cultured; Centrifugation, De | 1975 |
A new and highly sensitive radiotracer assay for orotate phosphoribosyltransferase.
Topics: Animals; Carbon Isotopes; Cell Line; Chromatography, Thin Layer; Enzyme Activation; Fluorouracil; Hy | 1972 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumo | 1972 |
Partially double-stranded RNA in mouse spleen cells: the effect of Rauscher virus infection.
Topics: Animals; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chromatography, DEAE-Cellulose; | 1972 |
Biochemical mechanism of drug resistance. VII. Inhibition of orotic acid metabolism by 5-azacytidine in leukemic mice sensitive and resistant to 5-azacytidine.
Topics: Animals; Antimetabolites; Carbon Isotopes; Cell-Free System; Depression, Chemical; Female; Leukemia, | 1968 |
Characteristics of mouse leukemic cells resistant to 5-azacytidine and 5-aza-2'-deoxycytidine.
Topics: Animals; Antimetabolites; Carbon Isotopes; DNA, Neoplasm; Female; Hydrocortisone; Kynurenine; Leukem | 1968 |