orotic acid has been researched along with Disease Models, Animal in 41 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury." | 3.75 | Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. ( Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Veveris, M; Vilskersts, R, 2009) |
| "In rats without arginine supplementation, low plasma levels of citrulline and arginine increased urinary excretion of orotate, and focal tubulointerstitial fibrosis was observed 6 weeks after 90% SBR." | 3.71 | Extremely short small bowel induces focal tubulointerstitial fibrosis. ( Hebiguchi, T; Imai, H; Kato, T; Komatsuda, A; Mizuno, M; Wakui, H; Yoshino, H, 2001) |
| "Fatty liver is known to be associated with increased mortality and morbidity after liver resection." | 1.31 | Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. ( Horsmans, Y; Lambotte, L; Picard, C; Saliez, A; Sempoux, C; Starkel, P; Van den Berge, V, 2002) |
| "The increase in neutral lipids during CCl4 poisoning is significantly reduced by pretreatment and--somewhat less--by posttreatment with EPL." | 1.25 | Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents. ( Bartsch, GG; Gerber, GB, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (43.90) | 18.7374 |
| 1990's | 5 (12.20) | 18.2507 |
| 2000's | 5 (12.20) | 29.6817 |
| 2010's | 6 (14.63) | 24.3611 |
| 2020's | 7 (17.07) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Fushimura, Y | 1 |
| Hoshino, A | 1 |
| Furukawa, S | 2 |
| Nakagawa, T | 1 |
| Hino, T | 1 |
| Taminishi, S | 1 |
| Minami, Y | 1 |
| Urata, R | 1 |
| Iwai-Kanai, E | 1 |
| Matoba, S | 1 |
| Oizel, K | 1 |
| Tait-Mulder, J | 1 |
| Fernandez-de-Cossio-Diaz, J | 1 |
| Pietzke, M | 1 |
| Brunton, H | 1 |
| Lilla, S | 1 |
| Dhayade, S | 1 |
| Athineos, D | 1 |
| Blanco, GR | 1 |
| Sumpton, D | 1 |
| Mackay, GM | 1 |
| Blyth, K | 1 |
| Zanivan, SR | 1 |
| Meiser, J | 1 |
| Vazquez, A | 1 |
| Hu, Y | 1 |
| Xu, J | 2 |
| Chen, Q | 1 |
| Liu, M | 1 |
| Wang, S | 1 |
| Yu, H | 2 |
| Zhang, Y | 1 |
| Wang, T | 1 |
| Sugahara, G | 1 |
| Yamasaki, C | 1 |
| Yanagi, A | 1 |
| Ogawa, Y | 1 |
| Fukuda, A | 1 |
| Enosawa, S | 1 |
| Umezawa, A | 1 |
| Ishida, Y | 1 |
| Tateno, C | 1 |
| Zabulica, M | 1 |
| Srinivasan, RC | 1 |
| Akcakaya, P | 1 |
| Allegri, G | 1 |
| Bestas, B | 1 |
| Firth, M | 1 |
| Hammarstedt, C | 1 |
| Jakobsson, T | 2 |
| Ellis, E | 1 |
| Jorns, C | 1 |
| Makris, G | 1 |
| Scherer, T | 1 |
| Rimann, N | 1 |
| van Zuydam, NR | 1 |
| Gramignoli, R | 1 |
| Forslöw, A | 1 |
| Engberg, S | 1 |
| Maresca, M | 1 |
| Rooyackers, O | 1 |
| Thöny, B | 1 |
| Häberle, J | 1 |
| Rosen, B | 1 |
| Strom, SC | 1 |
| Verma, H | 1 |
| Garg, R | 1 |
| Naglah, AM | 1 |
| Al-Omar, MA | 1 |
| Almehizia, AA | 1 |
| Bhat, MA | 1 |
| Afifi, WM | 1 |
| Al-Wasidi, AS | 1 |
| Al-Humaidi, JY | 1 |
| Refat, MS | 1 |
| Tarasenko, TN | 1 |
| Rosas, OR | 1 |
| Singh, LN | 1 |
| Kristaponis, K | 1 |
| Vernon, H | 1 |
| McGuire, PJ | 1 |
| Guo, Q | 1 |
| Wei, Y | 1 |
| Xia, B | 1 |
| Jin, Y | 1 |
| Liu, C | 1 |
| Pan, X | 1 |
| Shi, J | 1 |
| Zhu, F | 1 |
| Li, J | 1 |
| Qian, L | 1 |
| Liu, X | 1 |
| Cheng, Z | 1 |
| Jin, S | 1 |
| Lin, J | 2 |
| Wu, W | 1 |
| Liu, Y | 2 |
| Shi, D | 1 |
| Tian, Y | 1 |
| Zhan, Q | 1 |
| Wang, J | 1 |
| Xue, C | 1 |
| Brunetti-Pierri, N | 1 |
| Clarke, C | 1 |
| Mane, V | 1 |
| Palmer, DJ | 1 |
| Lanpher, B | 1 |
| Sun, Q | 1 |
| O'Brien, W | 1 |
| Lee, B | 1 |
| Ginn, SL | 1 |
| Cunningham, SC | 2 |
| Zheng, M | 1 |
| Spinoulas, A | 1 |
| Carpenter, KH | 1 |
| Alexander, IE | 2 |
| Vilskersts, R | 1 |
| Liepinsh, E | 1 |
| Kuka, J | 1 |
| Cirule, H | 1 |
| Veveris, M | 1 |
| Kalvinsh, I | 1 |
| Dambrova, M | 1 |
| Kok, CY | 1 |
| Dane, AP | 1 |
| Carpenter, K | 1 |
| Kizana, E | 1 |
| Kuchel, PW | 1 |
| Wang, L | 1 |
| Wang, H | 1 |
| Morizono, H | 1 |
| Bell, P | 1 |
| Jones, D | 1 |
| McMenamin, D | 1 |
| Batshaw, ML | 2 |
| Wilson, JM | 1 |
| Shimada, T | 1 |
| Tashiro, M | 1 |
| Kanzaki, T | 1 |
| Noda, T | 1 |
| Murakami, T | 1 |
| Takiguchi, M | 1 |
| Mori, M | 1 |
| Yamamura, K | 1 |
| Saheki, T | 2 |
| Morsy, MA | 1 |
| Zhao, JZ | 1 |
| Ngo, TT | 1 |
| Warman, AW | 1 |
| O'Brien, WE | 1 |
| Graham, FL | 1 |
| Caskey, CT | 1 |
| Yudkoff, M | 1 |
| McLaughlin, BA | 1 |
| Gorry, E | 1 |
| Anegawa, NJ | 1 |
| Smith, IA | 1 |
| Hyman, SL | 1 |
| Robinson, MB | 1 |
| Kiwaki, K | 1 |
| Kanegae, Y | 1 |
| Saito, I | 1 |
| Komaki, S | 1 |
| Nakamura, K | 1 |
| Miyazaki, JI | 1 |
| Endo, F | 1 |
| Matsuda, I | 1 |
| Jellinek, H | 1 |
| Takács, E | 1 |
| Hebiguchi, T | 1 |
| Kato, T | 1 |
| Yoshino, H | 1 |
| Mizuno, M | 1 |
| Wakui, H | 1 |
| Komatsuda, A | 1 |
| Imai, H | 1 |
| Rao, PM | 1 |
| Nagamine, Y | 1 |
| Roomi, MW | 1 |
| Rajalakshmi, S | 1 |
| Sarma, DS | 1 |
| Picard, C | 1 |
| Lambotte, L | 1 |
| Starkel, P | 1 |
| Sempoux, C | 1 |
| Saliez, A | 1 |
| Van den Berge, V | 1 |
| Horsmans, Y | 1 |
| Qureshi, IA | 1 |
| Letarte, J | 1 |
| Ouellet, R | 1 |
| Hara, Y | 1 |
| Tomizawa, S | 1 |
| Bartsch, GG | 1 |
| Gerber, GB | 1 |
| Harden, KK | 1 |
| Robinson, JL | 1 |
| Alvarado, JA | 1 |
| Azorín, I | 1 |
| Miñana, MD | 1 |
| Felipo, V | 1 |
| Grisolía, S | 1 |
| Gushiken, T | 1 |
| Yoshimura, N | 1 |
| Petzold, H | 1 |
| Kehoe, JM | 1 |
| Lust, G | 1 |
| Statter, M | 1 |
| Russell, A | 1 |
| Abzug-Horowitz, S | 1 |
| Pinson, A | 1 |
| Edreira, JG | 1 |
| Hirsch, RL | 1 |
| Kennedy, JA | 1 |
| Sidransky, H | 2 |
| Verney, E | 2 |
| Murty, CN | 1 |
| Pidemskiĭ, EL | 1 |
| Martiusheva, SM | 1 |
| Sapko, VI | 1 |
| Bajusz, E | 1 |
| Homburger, F | 1 |
| Baker, JR | 1 |
| Bogdonoff, P | 1 |
| Marchetti, M | 1 |
| Moruzzi, G | 1 |
| Stueckemann, J | 1 |
| Paretsky, D | 1 |
41 other studies available for orotic acid and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line, Tumor; Cytosol; Diabetes Mellitus, Type 2 | 2021 |
Formate induces a metabolic switch in nucleotide and energy metabolism.
Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Col | 2020 |
Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats.
Topics: Animals; China; Cholesterol; Disease Models, Animal; Down-Regulation; Flavonoids; Hep G2 Cells; Huma | 2020 |
Humanized liver mouse model with transplanted human hepatocytes from patients with ornithine transcarbamylase deficiency.
Topics: Ammonia; Animals; Child, Preschool; Disease Models, Animal; Female; Gene Expression Regulation; Hepa | 2021 |
Correction of a urea cycle defect after ex vivo gene editing of human hepatocytes.
Topics: Adult; Aged; Ammonia; Animals; Cells, Cultured; Child; Disease Models, Animal; Female; Gene Editing; | 2021 |
Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia.
Topics: Animals; Cholecalciferol; Diabetes Mellitus, Experimental; Disease Models, Animal; Dyslipidemias; Hy | 2020 |
A Novel Oxidovanadium (IV)-Orotate Complex as an Alternative Antidiabetic Agent: Synthesis, Characterization, and Biological Assessments.
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Hypoglycemic Agents; Insulin; Ligands; Liver; Ma | 2018 |
A new mouse model of mild ornithine transcarbamylase deficiency (spf-j) displays cerebral amino acid perturbations at baseline and upon systemic immune activation.
Topics: Amino Acid Sequence; Amino Acids; Animals; Biological Transport; Body Weight; Brain; Disease Models, | 2015 |
Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Drug Discovery; Drug Resistance, B | 2016 |
Eicosapentaenoic Acid-Enriched Phosphatidylcholine Attenuated Hepatic Steatosis Through Regulation of Cholesterol Metabolism in Rats with Nonalcoholic Fatty Liver Disease.
Topics: Animals; Carrier Proteins; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Disease Models, Animal; Eic | 2017 |
Phenotypic correction of ornithine transcarbamylase deficiency using low dose helper-dependent adenoviral vectors.
Topics: Adenoviridae; Amino Acid Metabolism, Inborn Errors; Animals; Disease Models, Animal; Genetic Therapy | 2008 |
In vivo assessment of mutations in OTC for dominant-negative effects following rAAV2/8-mediated gene delivery to the mouse liver.
Topics: Adenoviridae; Animals; Blotting, Western; Disease Models, Animal; Enzyme Induction; Gene Expression; | 2009 |
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Drug Synergism; Drug Ther | 2009 |
Induction and prevention of severe hyperammonemia in the spfash mouse model of ornithine transcarbamylase deficiency using shRNA and rAAV-mediated gene delivery.
Topics: 3' Untranslated Regions; Animals; Dependovirus; Disease Models, Animal; Gene Knockdown Techniques; G | 2011 |
Sustained correction of OTC deficiency in spf( ash) mice using optimized self-complementary AAV2/8 vectors.
Topics: Animals; Base Sequence; Conserved Sequence; Dependovirus; Disease Models, Animal; Genetic Therapy; G | 2012 |
Normalization of hair growth in sparse fur-abnormal skin and hair (SPF-ASH) mice by introduction of the rat ornithine transcarbamylase (OTC) gene.
Topics: Animals; Arginine; Citrulline; Crosses, Genetic; Disease Models, Animal; Female; Genetic Linkage; Ha | 1994 |
Patient selection may affect gene therapy success. Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes.
Topics: Adenoviridae; Animals; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Hu | 1996 |
The sparse fur mouse as a model for gene therapy in ornithine carbamoyltransferase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Animals; Avoidance Learning; Crosses, Ge | 1995 |
Correction of ornithine transcarbamylase deficiency in adult spf(ash) mice and in OTC-deficient human hepatocytes with recombinant adenoviruses bearing the CAG promoter.
Topics: Actins; Adenoviridae; Amino Acid Metabolism, Inborn Errors; Animals; Antibodies; Cells, Cultured; Di | 1996 |
[Morphological aspects of the effect of magnesium orotate therapy on changes in the vascular walls induced by cholesterol-rich diet].
Topics: Animals; Arteriosclerosis; Cholesterol, Dietary; Diet, Atherogenic; Disease Models, Animal; Hypercho | 1997 |
Extremely short small bowel induces focal tubulointerstitial fibrosis.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Fibrosis; Immunohistochemistry; Kidney; Male; | 2001 |
Orotic acid, a new promoter for experimental liver carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Animals; Arginine; Carcinogens; Diet; Disease Models, Animal; DNA; gamma-Glut | 1984 |
Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats.
Topics: Animal Feed; Animals; Blotting, Western; Bromodeoxyuridine; CDC2-CDC28 Kinases; Cholesterol; Choline | 2002 |
Ornithine transcarbamylase deficiency in mutant mice I. Studies on the characterization of enzyme defect and suitability as animal model of human disease.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Creatinine; Disease Models, Animal; Female; Liver; Ma | 1979 |
[The antigranuloma effect of fluocinolone acetonide by paper disk granuloma in rats (author's transl)].
Topics: Adrenalectomy; Animals; Disease Models, Animal; DNA; Female; Fluocinolone Acetonide; Granuloma; In V | 1977 |
Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents.
Topics: Acetates; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease M | 1975 |
Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria.
Topics: Adenine Phosphoribosyltransferase; Animals; Carboxy-Lyases; Cattle; Disease Models, Animal; Erythroc | 1987 |
The use of a liposome-encapsulated 5-fluoroorotate for glaucoma surgery: I. Animal studies.
Topics: Animals; Ciliary Body; Conjunctiva; Disease Models, Animal; Drug Carriers; Glaucoma; Intraocular Pre | 1989 |
A simple animal model of hyperammonemia.
Topics: Acetates; Ammonia; Animals; Citrulline; Disease Models, Animal; Glutamate Dehydrogenase; Liver; Male | 1989 |
Transient hyperammonemia during aging in ornithine transcarbamylase-deficient, sparse-fur mice.
Topics: Aging; Ammonia; Animals; Body Weight; Disease Models, Animal; Hair; Liver; Mice; Mice, Mutant Strain | 1985 |
[Liver tissue enzymes in rats with galactosamine hepatitis during simultaneous administration of choline-orotate].
Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Ch | 1973 |
Studies of the host response to infectious disease: alterations of RNA metabolism in mouse tissues.
Topics: Animals; Arbovirus Infections; Carbon Isotopes; Cell Nucleus; Disease Models, Animal; Infections; Ki | 1969 |
Abnormal orotic acid metabolism associated with acute hyperammonaemia in the rat.
Topics: Acetates; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Carbon Radioisotopes; Carboxy-Lyas | 1974 |
Production of fatty liver with dietary ethanol despite orotic acid supplementation.
Topics: Alcohol Drinking; Animals; Body Weight; Diet; Disease Models, Animal; Ethanol; Fatty Liver; Liver; M | 1974 |
Studies on mRNA of the livers of rats force-fed a threonine-devoid or complete diet.
Topics: Animal Nutritional Physiological Phenomena; Animals; Carbon Radioisotopes; Dactinomycin; Deficiency | 1974 |
[Effect of potassium orotate on the bile-secretion function of the liver in normal state and in experimental hepatitis].
Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dogs; Liver; Methods; | 1971 |
Dissociation of factors influencing myocardial degeneration and generalized cardiocirculatory failure.
Topics: Animals; Aspartic Acid; Cricetinae; Diet; Digitoxin; Disease Models, Animal; Edema; Epinephrine; Fem | 1969 |
Influence of orotic acid on liver tumorigenesis in rats ingesting ethionine, N-2-fluorenylacetamide, and 3'-methyl-dimethylaminoazobenzene.
Topics: Acetamides; Acetates; Amides; Animals; Azo Compounds; Benzene Derivatives; Body Weight; Diet; Diseas | 1970 |
[Biochemical mechanisms of steatosis as sequelae of "nucleotide imbalance"].
Topics: Acetates; Adenine; Adenine Nucleotides; Adenosine Triphosphate; Animals; Azaserine; Biotin; Carbon I | 1970 |
Changes in hepatic glycogen, protein, and ribonucleic acid synthesis, and some effects of cortisol, during Q fever.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Carbon Isotopes; Chromatography, Paper; Coxiella; Dise | 1971 |