orotic acid has been researched along with Choline Deficiency in 9 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid." | 7.67 | Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989) |
| " However, when females and males were exposed to four promotion regimens including orotic acid (OA), choline deficiency, deoxycholic acid (DOC), or selection for resistance (to 2-acetylaminofluorene; 2-AAF) after DEN initiation, very significant sex differences were observed with respect to oval cell proliferation and growth rates of hepatocytic foci." | 3.68 | Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine. ( Armstrong, D; Blanck, A; Cameron, RG, 1990) |
| "The activities of pathways for the biosynthesis of hippurate, urea and pyrimidines in hepatocytes isolated from lean livers were compared with those from three sources of fatty liver: a) the genetically obese Zucker rat, b) Sprague-Dawley rats fed a diet deficient in choline and inositol, and c) Sprague-Dawley rats fed a diet supplemented with orotic acid." | 3.67 | Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats. ( Maswoswe, SM; Tremblay, GC, 1989) |
| "In rats with steatohepatitis, mean elasticity (2." | 1.35 | Early detection of steatohepatitis in fatty rat liver by using MR elastography. ( Abarca-Quinones, J; Dorvillius, M; Fink, M; Larrat, B; Leclercq, I; Pallu, S; Salameh, N; Sinkus, R; Van Beers, BE, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salameh, N | 1 |
| Larrat, B | 1 |
| Abarca-Quinones, J | 1 |
| Pallu, S | 1 |
| Dorvillius, M | 1 |
| Leclercq, I | 1 |
| Fink, M | 1 |
| Sinkus, R | 1 |
| Van Beers, BE | 1 |
| Cameron, RG | 1 |
| Blanck, A | 1 |
| Armstrong, D | 1 |
| Laconi, E | 1 |
| Vasudevan, S | 1 |
| Rao, PM | 2 |
| Rajalakshmi, S | 2 |
| Sarma, DS | 2 |
| Maswoswe, SM | 1 |
| Tremblay, GC | 1 |
| Porta, EA | 2 |
| Manning, C | 1 |
| Hartroft, WS | 2 |
| Simon, JB | 2 |
| Scheig, R | 2 |
| Klatskin, G | 2 |
| Monserrat, AJ | 1 |
1 review available for orotic acid and Choline Deficiency
| Article | Year |
|---|---|
Liver tumour promotion by chemicals: models and mechanisms.
Topics: Cell Division; Choline Deficiency; Cocarcinogenesis; Humans; Liver Neoplasms; Orotic Acid; Phenobarb | 1986 |
8 other studies available for orotic acid and Choline Deficiency
| Article | Year |
|---|---|
Early detection of steatohepatitis in fatty rat liver by using MR elastography.
Topics: Animals; Carbon Tetrachloride; Choline Deficiency; Elasticity Imaging Techniques; Fatty Liver; Male; | 2009 |
Sex differences in response to four promotion regimens in spite of common first cellular steps in the hepatocellular cancer process initiated by diethylnitrosamine.
Topics: 2-Acetylaminofluorene; Animals; Cell Division; Choline Deficiency; Deoxycholic Acid; Diethylnitrosam | 1990 |
Complementarity between two rat liver tumor promoters.
Topics: Animals; Choline Deficiency; Diet; Diethylnitrosamine; gamma-Glutamyltransferase; Liver; Liver Neopl | 1987 |
Biosynthesis of hippurate, urea and pyrimidines in the fatty liver: studies with rats fed orotic acid or a diet deficient in choline and inositol, and with genetically obese (Zucker) rats.
Topics: Ammonium Chloride; Animals; Benzoates; Choline Deficiency; Diet; Fatty Liver; Gluconeogenesis; Hippu | 1989 |
The lipotropic action of orotic acid.
Topics: Animals; Body Weight; Cholesterol; Choline Deficiency; Diet; Histocytochemistry; Liver; Male; Micros | 1968 |
Protection by orotic acid against the renal necrosis and fatty liver of choline deficiency.
Topics: Adenine; Animals; Choline Deficiency; Fatty Liver; Hemorrhage; Kidney; Liver; Male; Necrosis; Orotic | 1968 |
Orotic acid effects on the kidney. Changes in choline-deficient weanling rats.
Topics: Animals; Blood Urea Nitrogen; Cholesterol; Choline Deficiency; Diet; Kidney; Lipids; Male; Microscop | 1969 |
Hepatic ATP and triglyceride levels in choline-deficient rats with and without dietary orotic acid supplementation.
Topics: Adenine; Adenosine Triphosphate; Animals; Choline Deficiency; Diet; Dietary Fats; Fatty Liver; Liver | 1969 |