Compounds > orotic acid
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orotic acid and Chemical and Drug Induced Liver Injury

orotic acid has been researched along with Chemical and Drug Induced Liver Injury in 35 studies

Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.

Research Excerpts

ExcerptRelevanceReference
" Liver and kidney samples were also taken at appropriate times after dosing and examined histologically for evidence of drug induced damage."1.26Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat. ( Clampitt, RB, 1978)
"The increase in neutral lipids during CCl4 poisoning is significantly reduced by pretreatment and--somewhat less--by posttreatment with EPL."1.25Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents. ( Bartsch, GG; Gerber, GB, 1975)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-199031 (88.57)18.7374
1990's2 (5.71)18.2507
2000's0 (0.00)29.6817
2010's1 (2.86)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Fourches, D1
Barnes, JC1
Day, NC1
Bradley, P1
Reed, JZ1
Tropsha, A1
Müller, FA1
Stamou, M1
Englert, FH1
Frenzel, O1
Diedrich, S1
Suter-Dick, L1
Wambaugh, JF1
Sturla, SJ1
KOPTE, J1
DECLOITRE, F1
LOWY, R1
CARTIER, P2
LEROUX, JP2
KOECHER, Z1
HABERMANNOVA, S1
CERHOVA, M1
SUVA, J1
Clifford, JI1
Rees, KR1
Fernández, G1
Villarruel, MC1
Bernacchi, A1
de Castro, CR1
Castro, JA1
Stachura, J1
Tarnawski, A1
Szczudrawa, J1
Bogdał, J1
Mach, T1
Klimczyk, B1
Kirchmayer, S1
Posokhova, EA1
Sadanobu, S1
Takeuchi, M1
Tezuka, M1
Clampitt, RB1
Bartsch, GG1
Gerber, GB1
Pickering, RW1
Lynn James, GW1
Parker, FL1
Erzsébet, FR1
György, L1
László, T1
Baĭbekova, EM1
Sultanova, LI1
Klein, A1
Pappas, SC1
Gordon, P1
Wong, A1
Kellen, J1
Kolin, A1
Robinson, JB1
Malkin, A1
Maeda, S1
Takeda, S1
Miyamoto, Y1
Aburada, M1
Harada, M1
Wallnöfer, H1
Gajdos, A1
Gajdos-Török, M1
Petzold, H2
Neupert, A1
Gravela, E1
Mészáros, K1
Antoni, F1
Hrabák, A1
Szikla, C1
Garzó, T1
Tompa, A1
Lapis, K1
Pal'tsyn, AA1
Fujisawa, K1
Okabe, K1
Tanaka, K1
Decker, K1
Keppler, D1
Rudigier, J1
Domschke, W1
Szelényi, I2
Nemesánszky, E2
Nagy, Z1
Nam, LB1
Romics, I1
Rigó, J1
Farkas, I1
Desi, I1
Pidemskiĭ, EL1
Martiusheva, SM1
Sapko, VI1
Kobayashi, T1
Friedman, MA1
Wogan, GN1
Dubin, HV1
Harrell, ER1
Villa-Treviño, S1
Leaver, DD1

Other Studies

35 other studies available for orotic acid and Chemical and Drug Induced Liver Injury

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI

2010
In vitro to in vivo extrapolation and high-content imaging for simultaneous characterization of chemically induced liver steatosis and markers of hepatotoxicity.
    Archives of toxicology, 2023, Volume: 97, Issue:6

    Topics: Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Fatty Liver

2023
[Hepato-protective action of oxypurines in experimental poisoning of rats with carbon tetrachloride].
    Hospital (Rio de Janeiro, Brazil), 1963, Volume: 63

    Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Hepatitis; Orotic Acid; Purin

1963
[EFFECT OF OROTIC ACID ON THE PROCESSES OF NECROSIS AND TISSUE REPAIR IN THE RAT].
    Enzymologia biologica et clinica, 1964, Volume: 74

    Topics: Adenine Nucleotides; Adenosine Triphosphate; Chemical and Drug Induced Liver Injury; Colorimetry; DN

1964
[INFLUENCE OF OROTIC ACID ON THE FREE NUCLEOTIDES IN THE RAT LIVER DURING TETRACHLORIDE POISONING].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Live

1964
[INFLUENCE OF INOSINIC ACID, ALONE OR COMBINED WITH OROTIC ACID, ON THE FREE NUCLEOTIDES IN THE RAT LIVER DURING CARBON TETRACHLORIDE POISONING].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1964, Volume: 158

    Topics: Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis; Hepatitis A; Inos

1964
THE INFLUENCE OF OROTIC ACID ON LIVER PARENCHYMA. IV. CHANGES IN SERUM AND LIVER LIPIDS DUE TO CHRONIC CARBON TETRACHLORIDE INTOXICATION.
    Acta vitaminologica, 1964, Volume: 18

    Topics: Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Choles

1964
The action of aflatoxin B1 on the rat liver.
    The Biochemical journal, 1967, Volume: 102, Issue:1

    Topics: Aflatoxins; Animals; Carbon Isotopes; Chemical and Drug Induced Liver Injury; DNA; Glutamate Dehydro

1967
Effects of repeated administration of rat 2-diethylaminoethyl-2-2-diphenylvalerate-HCI (SKF 525 A) on liver.
    Toxicology, 1981, Volume: 20, Issue:2-3

    Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Liver; Male; Microsomes, Liv

1981
Cytoprotective effect of 16, 16' dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rat.
    Folia histochemica et cytochemica, 1980, Volume: 18, Issue:4

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Chemical and Drug Induced Liver Injury; Choline; Drug Combi

1980
[Effect of orotic acid, calcium pangamate, and lipamide on ultrastructural changes in lipocytes in hepatic dystrophy].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:1

    Topics: Animals; Calcium Gluconate; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury;

1981
Effect of 1,3-dithia-2-thioxo-cyclopent-4-ene and its derivatives on liver injury induced by carbon tetrachloride and orotic acid in rats.
    The Journal of toxicological sciences, 1997, Volume: 22, Issue:5

    Topics: Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur

1997
Young Scientists Award Lecture 1977: An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1978, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Evaluation Studies

1978
Influence of phospholipids on liver damage. II. Changes in lipid content and synthesis after liver damage with carbontetrachloride and other agents.
    Acta hepato-gastroenterologica, 1975, Volume: 22, Issue:4

    Topics: Acetates; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Disease M

1975
Inhibition, by drugs, of galactosamine induced hepatitis in the rat.
    Arzneimittel-Forschung, 1975, Volume: 25, Issue:10

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Azathioprine; Chemical and Drug Induced

1975
[Liver-protecting effects of imidazole derivatives in acute liver damage].
    Acta pharmaceutica Hungarica, 1976, Volume: 46, Issue:2

    Topics: Acute Disease; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Imidazoles; L

1976
[Structure of the liver after correction of experimental chronic hepatitis with benzonal and potassium orotate].
    Arkhiv anatomii, gistologii i embriologii, 1990, Volume: 98, Issue:2

    Topics: Animals; Barbiturates; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Drug

1990
The effect of nonviral liver damage on the T-lymphocyte helper/suppressor ratio.
    Clinical immunology and immunopathology, 1988, Volume: 46, Issue:2

    Topics: Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Leukocyte Count; Necrosis; Orotic Ac

1988
Effects of gomisin A on liver functions in hepatotoxic chemicals-treated rats.
    Japanese journal of pharmacology, 1985, Volume: 38, Issue:4

    Topics: 1-Naphthylisothiocyanate; Animals; Bile; Carbon Tetrachloride Poisoning; Chemical and Drug Induced L

1985
[The treatment of hepatoses].
    Munchener medizinische Wochenschrift (1950), 1972, Feb-04, Volume: 114, Issue:5

    Topics: Biotransformation; Chemical and Drug Induced Liver Injury; Cholestasis; Diet Therapy; Fatty Liver; G

1972
[Effect of inosine on the experimentally decreased level of hepatic ATP].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1967, Volume: 161, Issue:3

    Topics: Adenosine Triphosphate; Animals; Chemical and Drug Induced Liver Injury; Ethanol; Ethionine; Liver;

1967
[Enzyme histochemical findings in the rat liver following galactosamine lesions and cholinorotate].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Dec-15, Volume: 27, Issue:24

    Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induce

1972
[Liver tissue enzymes in rats with galactosamine hepatitis during simultaneous administration of choline-orotate].
    Ceskoslovenska gynekologie, 1973, Volume: 27, Issue:5

    Topics: Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Chemical and Drug Induced Liver Injury; Ch

1973
Evidence for a reduced active life-span of messenger RNA in liver of rats poisoned with carbon tetrachloride.
    Experimental and molecular pathology, 1973, Volume: 19, Issue:1

    Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cycloheximide; Dact

1973
Prevention of the hepatotoxic effects of D-galactosamine by D-galactose.
    FEBS letters, 1973, Sep-01, Volume: 35, Issue:1

    Topics: Animals; Carbon Radioisotopes; Chemical and Drug Induced Liver Injury; Chromatography, Ion Exchange;

1973
[An autoradiographic study of DNA and RNA synthesis in the liver cells of mice with chronic carbon tetrachloride poisoning].
    Biulleten' eksperimental'noi biologii i meditsiny, 1973, Volume: 75, Issue:4

    Topics: Animals; Autoradiography; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Drug In

1973
[Acute hepatic disorders].
    Nihon rinsho. Japanese journal of clinical medicine, 1972, Volume: 30, Issue:1

    Topics: Acute Disease; Alcoholism; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver

1972
Cell damage by trapping of biosynthetic intermediates. The role of uracil nucleotides in experimental hepatitis.
    Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1971, Volume: 352, Issue:3

    Topics: Alanine Transaminase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Hepatitis;

1971
[Experimental liver lesions and its influencing by anorganic and organic magnesium salts].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:6

    Topics: Animals; Asparagine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chlorid

1971
[Effect of magnesium orotate glycinate on the brain electric activity after experimental ammonia poisoning].
    Arzneimittel-Forschung, 1971, Volume: 21, Issue:6

    Topics: Ammonia; Animals; Brain Diseases; Chemical and Drug Induced Liver Injury; Electroencephalography; Fe

1971
[Effect of potassium orotate on the bile-secretion function of the liver in normal state and in experimental hepatitis].
    Patologicheskaia fiziologiia i eksperimental'naia terapiia, 1971, Volume: 15, Issue:1

    Topics: Animals; Bile; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dogs; Liver; Methods;

1971
[Pharmacological studies on liver-acting agents 2. Effects of so-called liver drugs on the ethionine-damaged liver].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1966, Nov-20, Volume: 62, Issue:6

    Topics: Animals; Bile Acids and Salts; Blood Proteins; Chemical and Drug Induced Liver Injury; Ethionine; Gl

1966
Liver nuclear RNA metabolism in rats treated with aflatoxin B1.
    Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1970, Jul-08, Volume: 9, Issue:13

    Topics: Aflatoxins; Animals; Carbon Isotopes; Cell Nucleus; Centrifugation; Chemical and Drug Induced Liver

1970
Azaribine in the treatment of psoriasis.
    Annals of internal medicine, 1971, Volume: 74, Issue:5

    Topics: Chemical and Drug Induced Liver Injury; DNA; Humans; Methotrexate; Orotic Acid; Psoriasis; Time Fact

1971
Effects of the hepatotoxic agents retrorsine and aflatoxin B1 on hepatic protein synthesis in the rat.
    The Biochemical journal, 1968, Volume: 109, Issue:1

    Topics: Aflatoxins; Alkaloids; Animals; Blood Proteins; Carbon Isotopes; Cell Nucleus; Cell-Free System; Che

1968