orotic acid has been researched along with Cardiovascular Stroke in 23 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Myocardial infarction causes reversible depression of resting function and beta-adrenergic responsiveness in the remote and border zone areas, which is not prevented by metabolic therapy with orotic acid." | 7.69 | Depressed function in remote myocardium after myocardial infarction: influence of orotic acid. ( Cochrane, AD; Conyers, RA; Pathik, S; Rosenfeldt, FL; Smolich, JJ, 1996) |
| "The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury." | 3.75 | Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart. ( Cirule, H; Dambrova, M; Kalvinsh, I; Kuka, J; Liepinsh, E; Veveris, M; Vilskersts, R, 2009) |
| "Myocardial infarction causes reversible depression of resting function and beta-adrenergic responsiveness in the remote and border zone areas, which is not prevented by metabolic therapy with orotic acid." | 3.69 | Depressed function in remote myocardium after myocardial infarction: influence of orotic acid. ( Cochrane, AD; Conyers, RA; Pathik, S; Rosenfeldt, FL; Smolich, JJ, 1996) |
| "On a model of experimental myocardial infarction there is demonstrated the stimulating effect of inosine (most distinctly) and also of stimulants of the nucleic acids synthesis and of retabolil on the formation of the post-infarction scar, the processes of compensatory hyperfunction and hypertrophy, all this finally speeding up the restoration of the myocardial function as a whole." | 3.65 | [Ways of drug action on the restorative processes in the myocardium in experimental myocardial infarct]. ( Cherpachenko, NM; Golikov, PP; Nikolaeva, LF; Sokolova, RI; Veselova, SP, 1975) |
| "Treatment with orotic acid produced a further upward trend in uridine nucleotide levels." | 1.28 | The effect of orotic acid on the response of the recently infarcted rat heart to hypothermic cardioplegia. ( Conyers, RA; Langley, LH; Munsch, CM; O'Halloran, K; Rosenfeldt, FL; Williams, JF, 1991) |
| "Myocardial infarction was induced in rats by coronary ligation, and after 2 days or 3 days the hearts were excised and perfused on the working heart apparatus." | 1.28 | The impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: the protective effect of orotic acid. ( Munsch, C; Rosenfeldt, FL; Williams, JF, 1989) |
| "Orotic acid is a precursor of nucleic acids with the ability to enhance protein synthesis." | 1.28 | Sensitivity of the recently infarcted heart to cardioplegic arrest. Beneficial effect of pretreatment with orotic acid. ( Chen, XZ; Newman, MA; Rabinov, M; Rosenfeldt, FL; Williams, JF, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (73.91) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 2 (8.70) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Varatharajah, K | 1 |
| Rosenfeldt, FL | 7 |
| Vilskersts, R | 1 |
| Liepinsh, E | 1 |
| Kuka, J | 1 |
| Cirule, H | 1 |
| Veveris, M | 1 |
| Kalvinsh, I | 1 |
| Dambrova, M | 1 |
| Belyĭ, IS | 1 |
| Sukhodol'skiĭ, AM | 1 |
| Cochrane, AD | 1 |
| Pathik, S | 1 |
| Smolich, JJ | 1 |
| Conyers, RA | 4 |
| Richards, SM | 2 |
| Fisher, JL | 1 |
| Lin, Z | 1 |
| Pepe, S | 1 |
| Nikolaeva, LF | 2 |
| Cherpachenko, NM | 2 |
| Sokolova, RI | 2 |
| Veselova, SP | 1 |
| Golikov, PP | 1 |
| Demin, AA | 1 |
| Krylov, BV | 1 |
| Tomov, L | 1 |
| Kaloianova, A | 1 |
| Munsch, CM | 1 |
| O'Halloran, K | 1 |
| Langley, LH | 1 |
| Williams, JF | 3 |
| Munsch, C | 1 |
| Newman, MA | 1 |
| Chen, XZ | 1 |
| Rabinov, M | 1 |
| Veselova, SA | 1 |
| O'Sullivan, WJ | 1 |
| Tsimmerman, IaS | 1 |
| Rusinova, VG | 1 |
| Kleĭmenova, NN | 1 |
| Alekseeva, SP | 1 |
| Belen'kiĭ, EE | 1 |
| Szabó, J | 1 |
| Csáky, L | 1 |
| Wexler, BC | 1 |
| Judd, JT | 1 |
| Lutmer, RF | 1 |
| Saroff, J | 1 |
| Zharov, EI | 3 |
| Kheĭnonen, IM | 1 |
| Makeeva, GK | 1 |
| Villányi, P | 1 |
| Votin, J | 1 |
| Rahlfs, V | 1 |
| Lukomskiĭ, PE | 1 |
| Meerson, FZ | 1 |
| Solov'ev, VV | 1 |
| Shenderov, SM | 1 |
| Markovskaia, GI | 2 |
| Mdinaradze, IuS | 1 |
| Arshakuni, RO | 1 |
| Taraeva, NG | 1 |
| Iurasov, VS | 1 |
2 reviews available for orotic acid and Cardiovascular Stroke
| Article | Year |
|---|---|
[Stimulation of the restorative processes in myocardial infarct].
Topics: Amino Acids; Anabolic Agents; Animals; Cardiac Glycosides; DNA; Drug Therapy, Combination; Folic Aci | 1976 |
Orotic acid.
Topics: Allopurinol; Anemia, Pernicious; Animals; Azauridine; Carboxy-Lyases; Fatty Liver; Female; Humans; I | 1973 |
21 other studies available for orotic acid and Cardiovascular Stroke
| Article | Year |
|---|---|
Changes in noninfarcted myocardium explain benefits of on-pump beating-heart coronary artery bypass grafting for acute myocardial infarction.
Topics: Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction | 2009 |
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Disease Models, Animal; Drug Synergism; Drug Ther | 2009 |
[Myocardial lesions in acute surgical pathology of the abdominal organs].
Topics: Abdomen, Acute; Adult; Aged; Cardiomyopathies; Electrocardiography; Female; Humans; Male; Middle Age | 1980 |
Depressed function in remote myocardium after myocardial infarction: influence of orotic acid.
Topics: Adrenergic beta-Antagonists; Animals; Dogs; Echocardiography; Heart; Myocardial Contraction; Myocard | 1996 |
Cardioprotection by orotic acid: metabolism and mechanism of action.
Topics: Adenine Nucleotides; Animals; Energy Metabolism; Heart; Liver; Male; Myocardial Infarction; Myocardi | 1997 |
Mechanism of cardioprotective effect of orotic acid.
Topics: Adenine Nucleotides; Animals; Heart; Hypoxia; In Vitro Techniques; Liver; Male; Myocardial Contracti | 1998 |
[Ways of drug action on the restorative processes in the myocardium in experimental myocardial infarct].
Topics: Aminopeptidases; Animals; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Esterases; | 1975 |
[Changes in hemodynamics in acute myocardial infarct following administration of potassium orotate].
Topics: Acute Disease; Blood Circulation Time; Blood Volume; Cardiac Output; Female; Humans; Male; Myocardia | 1976 |
The effect of orotic acid on the response of the recently infarcted rat heart to hypothermic cardioplegia.
Topics: Animals; Blood Pressure; Cardiac Output; Heart; Heart Arrest, Induced; Ischemia; Male; Myocardial In | 1991 |
The impaired tolerance of the recently infarcted rat heart to cardioplegic arrest: the protective effect of orotic acid.
Topics: Animals; Heart; Heart Arrest; Heart Arrest, Induced; In Vitro Techniques; Myocardial Infarction; Oro | 1989 |
Sensitivity of the recently infarcted heart to cardioplegic arrest. Beneficial effect of pretreatment with orotic acid.
Topics: Animals; Body Water; Cardioplegic Solutions; Dogs; Heart Arrest, Induced; Myocardial Infarction; Myo | 1989 |
Mechanisms of drug action on recovery processes of cardiac muscle in myocardial infarction.
Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Animals; Dihydrolipoamide Dehydrogenase; Es | 1974 |
[Clinical labortory evaluation of the effectiveness of the overall treatment of myocardial infarct using nucleic acid synthesis cofactors and precursors].
Topics: Adult; Aged; Anticoagulants; Blood Proteins; Calcium; Cardiac Glycosides; Electrocardiography; Femal | 1973 |
[The effect of potassium orotate on the ultrastructure of cardiac muscle cells in experimental myocardial infarct].
Topics: Animals; Cell Nucleus; Cytoplasmic Granules; Endoplasmic Reticulum; Glycogen; Histocytochemistry; Mi | 1973 |
[Myocardial necrosis induced with isoproterenol in rat heart].
Topics: Animals; Carbon Radioisotopes; Heart; Hypoxia; Isoproterenol; Myocardial Infarction; Myocardium; Nec | 1974 |
Metabolic and histopathological consequences of a fatty liver during the acute stages of myocardial infarction in rats.
Topics: Acute Disease; Adrenal Glands; Alanine Transaminase; Aldosterone; Animals; Aspartate Aminotransferas | 1971 |
[Use of cofactors of the synthesis and precursors of nucleic acids in myocardial infarct patients].
Topics: Blood Circulation Time; Blood Pressure; Cardiac Output; Female; Folic Acid; Humans; Hypertension; Ma | 1971 |
[Effect of potassium orotate on the course of myocardial infarct].
Topics: Female; Folic Acid; Heart; Humans; Male; Myocardial Infarction; Orotic Acid; Vitamin B 12 | 1970 |
[Arteriosclerosis, myocardial infarct and blood lipids, their therapeutic modification by magnesium orotate].
Topics: Age Factors; Aged; Aorta; Arteriosclerosis; Cholesterol; Depression, Chemical; Humans; Lipids; Magne | 1970 |
[Disturbances of contractile function of the heart in myocardial infarct and the therapeutic use of cofactors of synthesis and precursors of nucleic acids].
Topics: Animals; Aorta; Arteries; Blood Flow Velocity; Blood Pressure; Cardiac Output; Constriction; Dogs; F | 1967 |
[Effect of the cofactors of synthesis and precursors of nucleic acids on the state of the myocardium in myocardial infarct according to electrocardiographic data].
Topics: Animals; Electrocardiography; Female; Folic Acid; Heart; Humans; Male; Middle Aged; Myocardial Infar | 1968 |