orotic acid has been researched along with Cardiomegaly in 10 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 5.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| "Amlodipine orotate was prepared by reacting orotic acid and amlodipine to increase the dissolution rate at higher gastric pH conditions." | 1.33 | Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats. ( Ahn, BO; Choi, SM; Kim, JE; Kwon, JW, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (80.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MEERSON, FZ | 2 |
| Choi, SM | 1 |
| Kim, JE | 1 |
| Ahn, BO | 1 |
| Kwon, JW | 1 |
| Donohoe, JA | 2 |
| Rosenfeldt, FL | 1 |
| Munsch, CM | 1 |
| Williams, JF | 4 |
| Donohoe, J | 1 |
| Lykke, A | 1 |
| Kolos, G | 3 |
| Mertz, DP | 1 |
| Rusteborg, J | 1 |
| Pomoinitsky, VD | 1 |
| Hickie, JB | 2 |
| Meerson, FS | 1 |
| Iavich, MP | 1 |
| Lerman, MI | 1 |
| Fanburg, BL | 1 |
| Matsushita, S | 1 |
| Raben, MS | 1 |
10 other studies available for orotic acid and Cardiomegaly
| Article | Year |
|---|---|
A MECHANISM OF HYPERTROPHY AND WEAR OF THE MYOCARDIUM.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Aortic Valve Stenosis; Cardiomegaly; Car | 1965 |
Effects of amlodipine orotate on hypertension-related complications in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium; Cardiomegaly; Ce | 2006 |
The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carbohydrate Metabo | 1993 |
Studies using orotic acid for improving the controlled development of myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Energy Metabolism; Glycogen; Leucine; Male; Myocardial Contraction; Myocardiu | 1976 |
[Duplication of the left atrioventricular orifice (author's transl)].
Topics: Adult; Allopurinol; Arrhythmias, Cardiac; Blood Glucose; Cardiomegaly; Cholesterol; Diphosphates; El | 1975 |
The role of high-energy phosphate compounds in the development of cardiac hypertrophy.
Topics: Acclimatization; Adenosine Triphosphate; Alanine; Animals; Aorta; Atmosphere Exposure Chambers; Carb | 1972 |
Biochemical studies in myocardial hypertrophy and metabolic support of the acutely stressed myocardium.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cardiomegaly; Creatine Kinase; Heart; Hy | 1974 |
Role of total ribonucleic acid concentration and the ratio of translating and nontranslating ribosomes in development of compensatory hypertrophy of the heart.
Topics: Animals; Carbon Radioisotopes; Cardiomegaly; Cattle; Centrifugation, Density Gradient; Male; Models, | 1974 |
The action of orotic acid as a positive inotropic agent during the acute phase of myocardial hypertrophy.
Topics: Acute Disease; Animals; Cardiomegaly; Folic Acid; Leucine; Male; Myocardial Contraction; Myocardium; | 1974 |
Nucleic acid metabolism in cardiac hypertrophy.
Topics: Animals; Cardiomegaly; Dactinomycin; DNA; Male; Myocardium; Nucleic Acid Precursors; Ornithine Decar | 1973 |