Compounds > orotic acid
Page last updated: 2024-10-19

orotic acid and Carcinoma, Hepatocellular

orotic acid has been researched along with Carcinoma, Hepatocellular in 47 studies

Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Research Excerpts

ExcerptRelevanceReference
"Orotic acid (OA) has been intensively utilized to induce fatty liver in rats."5.56Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. ( Käkelä, R; Matilainen, J; Mustonen, AM; Nieminen, P; Rilla, K; Sihvo, SP, 2020)
"Orotic acid (OA) has been intensively utilized to induce fatty liver in rats."1.56Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism. ( Käkelä, R; Matilainen, J; Mustonen, AM; Nieminen, P; Rilla, K; Sihvo, SP, 2020)
"A young patient with hepatocellular carcinoma receiving chemotherapy presented with encephalopathy."1.35Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency. ( Blanke, CD; Chan, JS; Harding, CO, 2008)
"However, the incidence of hepatocellular carcinoma was greatly increased in animals exposed to the orotic acid diet, with 42% incidence in initiated rats given orotic acid diet for 10 weeks and up to 75% in those exposed to this diet for 40 weeks."1.29Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis. ( Denda, A; Laconi, E; Pani, P; Rajalakshmi, S; Rao, PM; Sarma, DS, 1993)
"Furthermore, Ehrlich ascites tumor cells indicating a high incorporation activity was also high in activities of both phosphorylase and kinase for uridine, while Rhodamine sarcoma as a representative having a low incorporation activity was considerably low in these two enzymic activities."1.26Incorporation characteristics of uracil, uridine, and orotic acid into ribonucleic acid of neoplastic cells. ( Tamemasa, O; Tezuka, M, 1977)
"In the two hepatomas the turnover of mRNA of free polyribosomes was at a similar rate as that of membrane bound polyribosomes."1.26Turnover of messenger RNA in transplantable hepatomas and host liver of rats. ( Murty, CN; Sidransky, H; Verney, E, 1978)
"Zajdela ascitic hepatoma cells are shown to take up pyrimidine bases at much lower rates than obtained in slices from normal rat liver."1.25Uptake in vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells. ( Bhargava, PM; Bornecque, CA; Szafarz, D; Zajdela, F, 1975)
"3."1.25Diversity and nature of ribosomal pools in hepatoma 7800 and host liver. ( Kwan, SW; Morris, HP; Webb, TE, 1968)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199042 (89.36)18.7374
1990's3 (6.38)18.2507
2000's1 (2.13)29.6817
2010's0 (0.00)24.3611
2020's1 (2.13)2.80

Authors

AuthorsStudies
Matilainen, J1
Mustonen, AM1
Rilla, K1
Käkelä, R1
Sihvo, SP1
Nieminen, P1
MANDEL, P1
WINTZERITH, M1
BORKOWSKA, I1
MANDEL, L1
BRESNICK, E2
BLATCHFORD, K1
JACOB, ST1
BHARGAVA, PM2
Chan, JS1
Harding, CO1
Blanke, CD1
Denda, A2
Laconi, E2
Rao, PM2
Rajalakshmi, S2
Sarma, DS2
Pani, P1
Liau, MC1
Hunt, ME1
Hurlbert, RB1
Mitchell, AD1
Hoogenraad, NJ2
Szafarz, D1
Bornecque, CA1
Zajdela, F1
Letnansky, K1
Pausch, JG1
Keppler, DO1
Gerok, W2
Tezuka, M1
Tamemasa, O1
Sidransky, H1
Murty, CN1
Verney, E1
Keppler, D1
Pausch, J1
Lea, MA4
Luke, A1
Assad, A1
Patel, M1
Reddy, PA1
Harley, EH1
Sacks, S1
Berman, P1
Cohen, L1
Simmonds, HA1
Fairbanks, LD1
Black, D1
Boctor, A1
Grossman, A1
Mayfield, ED1
Lyman, K1
Wilkinson, BR1
Kirby, KS2
Otsuka, H2
Terayama, H3
Webb, TE3
Parish, JH1
Drews, J1
Brawerman, G1
Morris, HP5
Muramatsu, M1
Higashinakagawa, T1
Ono, T1
Sugano, H1
Matsudaira, H1
Nakamura, C1
Hishizawa, T1
Kwan, SW1
Rizzo, AJ1
Miyamoto, M2
Plagemann, PG1
Dijkstra, J1
Weide, SS1
Shapot, VS1
Vornovitskaya, GI1
Gorozhanskaya, EG1
Davidova, SY1
Zhubanova, AA1
Krechetova, GD1
Chudinova, IA1
Lafarge, C1
Frayssinet, C1
Sweeney, MJ3
Hoffman, DH3
Miller, S1
Mackauf, I1
Hirschberg, E1
Van Buskirk, JJ1
Kirsch, WM1
Khalil, FL2
Rey, MI1
Winsnes, A1
Rugstad, HE1
Smuckler, EA1
Koplitz, M1
Shearer, RW1
Lee, DC1
Tidwell, T1
Howard, E1
Bullock, J1
Parton, JW1

Reviews

2 reviews available for orotic acid and Carcinoma, Hepatocellular

ArticleYear
[Selective chemotherapy of hepatocellular carcinomas].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1978, Issue:84

    Topics: Animals; Carcinoma, Hepatocellular; Doxorubicin; Fluorouracil; Humans; Liver Neoplasms; Liver Neopla

1978
Notes on some peculiarities of enzymic processes in malignant tumours and tissues of the host.
    Neoplasma, 1972, Volume: 19, Issue:4

    Topics: Adenine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Catalase; Cholesterol; DNA, Neoplasm;

1972

Other Studies

45 other studies available for orotic acid and Carcinoma, Hepatocellular

ArticleYear
Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism.
    Lipids in health and disease, 2020, Apr-13, Volume: 19, Issue:1

    Topics: Carcinoma, Hepatocellular; Discriminant Analysis; Fatty Acids; Gene Expression Regulation, Neoplasti

2020
[ON THE EXISTENCE OF RAPIDLY LABELED DESOXYRIBONUCLEIC FRACTION IN ANIMAL CELLS].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences, 1964, Feb-10, Volume: 258

    Topics: Adenine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; DNA; Liver; Liver Neoplasms; Neoplasm

1964
STUDIES ON DIHYDROOROTASE ACTIVITY IN PREPARATIONS FROM NOVIKOFF ASCITES HEPATOMA CELLS.
    Archives of biochemistry and biophysics, 1964, Volume: 104

    Topics: Ascites; Carcinoma, Hepatocellular; Cyanides; Cysteine; Dihydroorotase; Enzyme Inhibitors; Hot Tempe

1964
COMPARISON OF THE URACIL CATABOLIC ACTIVITY OF LIVER CELL SUSPENSIONS AND SLICES.
    Biochimica et biophysica acta, 1964, Dec-16, Volume: 91

    Topics: Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Hepatocytes; Liver; Liver Neoplasms; Met

1964
Postchemotherapy hyperammonemic encephalopathy emulating ornithine transcarbamoylase (OTC) deficiency.
    Southern medical journal, 2008, Volume: 101, Issue:5

    Topics: Adult; Arginine; Carcinoma, Hepatocellular; Citrulline; Female; Glutamine; Hepatic Encephalopathy; H

2008
Sequential histopathological analysis of hepatocarcinogenesis in rats during promotion with orotic acid.
    Cancer letters, 1994, Jul-15, Volume: 82, Issue:1

    Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Carcinoma, Hepatocellular; Cocarcinogenesis; Diet; Dime

1994
Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis.
    Carcinogenesis, 1993, Volume: 14, Issue:9

    Topics: Animals; Body Weight; Carcinogens; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Live

1993
Role of ribosomal RNA methylases in the regulation of ribosome production in mammalian cells.
    Biochemistry, 1976, Jul-13, Volume: 15, Issue:14

    Topics: Adenosine Triphosphate; Animals; Carcinoma, Hepatocellular; Cell Nucleolus; Hydrogen-Ion Concentrati

1976
De novo pyrimidine nucleotide biosynthesis in synchronized rat hepatoma (HTC) cells and mouse embryo fibroblast (3T3) cells.
    Experimental cell research, 1975, Volume: 93, Issue:1

    Topics: Animals; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synthase (Ammonia); Carbon Dioxide; Car

1975
Uptake in vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells.
    The Journal of membrane biology, 1975, Jul-24, Volume: 22, Issue:3-4

    Topics: Adenine; Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; DNA; DNA, Bact

1975
The phosphorylation of nuclear proteins in the regenerating and premalignant rat liver and its significance for cell proliferation.
    Cell and tissue kinetics, 1975, Volume: 8, Issue:5

    Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Cell Division; Cell Transformation, Neoplastic; C

1975
Increased de novo pyrimidine nucleotide synthesis in liver induced by ammonium ions in amounts surpassing the urea cycle capacity.
    European journal of biochemistry, 1977, Jun-01, Volume: 76, Issue:1

    Topics: Animals; Azauridine; Carbamoyl-Phosphate Synthase (Ammonia); Carbamoyl-Phosphate Synthase (Glutamine

1977
Incorporation characteristics of uracil, uridine, and orotic acid into ribonucleic acid of neoplastic cells.
    Gan, 1977, Volume: 68, Issue:3

    Topics: Adult; Aged; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Female; Humans; Liver; Li

1977
Turnover of messenger RNA in transplantable hepatomas and host liver of rats.
    Cancer research, 1978, Volume: 38, Issue:6

    Topics: Animals; Carcinoma, Hepatocellular; Dactinomycin; Female; Liver; Liver Neoplasms; Neoplasm Transplan

1978
Inhibitory action of orotate, 2-thioorotate and isoorotate on nucleotide metabolism and nucleic acid synthesis in hepatoma cells.
    The International journal of biochemistry, 1992, Volume: 24, Issue:9

    Topics: Animals; Carcinoma, Hepatocellular; Cell Line; DNA, Neoplasm; Humans; Liver Neoplasms; Nucleotides;

1992
Source and fate of circulating pyrimidines.
    Advances in experimental medicine and biology, 1986, Volume: 195 Pt A

    Topics: Aspartic Acid; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Chromatography, High Pres

1986
Differential sensitivity of rat liver and rat hepatoma cells to alpha-amanitin.
    Biochemical pharmacology, 1973, Jan-01, Volume: 22, Issue:1

    Topics: Adrenalectomy; Animals; Basidiomycota; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus

1973
Incorporation of bicarbonate-14 C into pyrimidines and into ribonucleic acid of the Novikoff ascites tumor cell.
    Cancer research, 1967, Volume: 27, Issue:3

    Topics: Ammonia; Animals; Aspartic Acid; Bicarbonates; Carcinoma, Hepatocellular; Chromatography, Ion Exchan

1967
Studies in rapidly labelled ribonucleic acid in cell fractions and in tumour tissues.
    The Biochemical journal, 1966, Volume: 99, Issue:3

    Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Live

1966
Inhibition of DNA synthesis in ascites hepatoma cells by normal liver extract.
    Biochimica et biophysica acta, 1966, Aug-17, Volume: 123, Issue:2

    Topics: Animals; Azo Compounds; Carcinoma, Hepatocellular; DNA, Neoplasm; Electrophoresis; In Vitro Techniqu

1966
Polyribosome breakdown in rat liver following administration of 8-azaguanine.
    Biochimica et biophysica acta, 1967, Apr-18, Volume: 138, Issue:2

    Topics: Animals; Azaguanine; Carbon Isotopes; Carcinoma, Hepatocellular; Dactinomycin; Liver; Liver Neoplasm

1967
An extension of the naphthalene disulphonate method for mammalian nucleic acids.
    Biochimica et biophysica acta, 1967, Jun-20, Volume: 142, Issue:1

    Topics: Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; DNA; Liver; Liver Neoplasms; Mice; Nap

1967
A growth regulating factor in rat liver.
    The Wistar Institute symposium monograph, 1967, Volume: 7

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Division; Culture Techniques; DNA; DNA Nuc

1967
Nuclear RNA patterns in rat liver and hepatomas.
    Die Naturwissenschaften, 1967, Volume: 54, Issue:23

    Topics: Animals; Carcinoma, Hepatocellular; Cell Nucleus; Chemical Phenomena; Chemistry; Hybridization, Gene

1967
The nucleolar RNA of minimal deviation hepatomas.
    Cancer research, 1968, Volume: 28, Issue:6

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Nucleolus; Centrifugation, Density Gradien

1968
Some characteristics in the pathway of RNA synthesis in hepatoma cells.
    Gan, 1968, Volume: 59, Issue:1

    Topics: Animals; Ascites; Autoradiography; Carbon Isotopes; Carcinoma, Hepatocellular; Liver Neoplasms; Male

1968
Diversity and nature of ribosomal pools in hepatoma 7800 and host liver.
    The Biochemical journal, 1968, Volume: 109, Issue:4

    Topics: Animals; Azaguanine; Carbon Isotopes; Carbon Tetrachloride; Carcinoma, Hepatocellular; Dactinomycin;

1968
Ribosome formation in rat liver: evidence for post-transcriptional control.
    Biochimica et biophysica acta, 1969, Nov-19, Volume: 195, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Antimetabolites; Azaguanine; Carbon Isotopes; Carcinoma, Hepatocellu

1969
Nature of rat liver cell sap factors inhibiting the DNA synthesis in tumour cells.
    Biochimica et biophysica acta, 1971, Jan-28, Volume: 228, Issue:2

    Topics: Animals; Animals, Newborn; Arginase; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocel

1971
Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle.
    Journal of cellular physiology, 1971, Volume: 77, Issue:2

    Topics: Animals; Aspartic Acid; Biological Transport; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line;

1971
Changes in chromatin caused by aminoazo compounds.
    Experimental cell research, 1972, Volume: 72, Issue:2

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Chromatin; DN

1972
Tumor cell sap factor stimulating orotate incorporation into nucleic acids in ascites hepatoma cells.
    Biochimica et biophysica acta, 1972, Jul-31, Volume: 272, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Carcinoma, Hepatocellular; Cytoplasm; Diphosphate

1972
[Minor role of the de novo pathway in the biosynthesis of RNA during fetal and neoplastic liver development in rats].
    Biochimie, 1972, Volume: 54, Issue:4

    Topics: Aflatoxins; Age Factors; Animals; Carcinoma, Hepatocellular; Cyclic AMP; Female; Glucagon; Injection

1972
Dihydroorotate dehydrogenase in liver and Morris hepatomas.
    Cancer research, 1973, Volume: 33, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Fasting; Hepatectomy; Hydrogen-Ion Concentration; Kinetics; Live

1973
Orotate phosphoribosyl transferase and orotidylic acid decarboxylase activities in liver and Morris hepatomas.
    Cancer research, 1973, Volume: 33, Issue:5

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Hydro-Lyases; Hydrogen-Ion Concentration; Kinet

1973
Action of miracil D and related compounds on DNA and RNA synthesis in regenerating liver and hepatomas.
    International journal of cancer, 1972, May-15, Volume: 9, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; DNA; Hepatectomy; Liver Neoplasms; Liver Regeneration; Lucanthon

1972
Loss of hepatoma ribosomal RNA during warfarin therapy.
    Biochemical and biophysical research communications, 1973, May-15, Volume: 52, Issue:2

    Topics: Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Liver; Liver Neoplasms

1973
Effects of formamidoxime on macromolecular synthesis in regenerating liver and hepatomas.
    Chemico-biological interactions, 1973, Volume: 6, Issue:6

    Topics: Amino Acids; Animals; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Depression, Chemical; DNA;

1973
Different properties of microsomal UDP-glucuronyltransferase in buffalo rat liver and a clonal strain of rat hepatoma cells derived from the same rat strain.
    Acta pharmacologica et toxicologica, 1973, Volume: 33, Issue:3

    Topics: Animals; Carcinoma, Hepatocellular; Clone Cells; Coumarins; Digitonin; Edetic Acid; Female; Glucosam

1973
Altered nuclear RNA transport associated with carcinogen intoxication in rats.
    Biochemical and biophysical research communications, 1973, Nov-16, Volume: 55, Issue:2

    Topics: Animals; Biological Transport; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Centri

1973
Irreversibility of the alteration in RNA transport induced by an azo-dye carcinogen in the rat liver.
    Biochemical and biophysical research communications, 1974, Apr-08, Volume: 57, Issue:3

    Topics: Aging; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; DNA, Neopl

1974
Effect of uridine on de novo pyrimidine biosynthesis in rat hepatoma cells in culture.
    The Journal of biological chemistry, 1974, May-10, Volume: 249, Issue:9

    Topics: Amidohydrolases; Animals; Aspartate Carbamoyltransferase; Carbamates; Carbon Dioxide; Carbon Radiois

1974
The thiolation, methylation, and formation of pseudouridine and dihydrouridine in tRNA of regenerating rat liver, human phytohemagglutinin stimulated lymphocytes, and Novikoff ascites cells.
    Cell differentiation, 1972, Volume: 1, Issue:3

    Topics: Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cells, Cultured; Cysteine; Electrophoresis

1972
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
    Cancer research, 1974, Volume: 34, Issue:12

    Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Inje

1974
Biosynthesis of uridine-5'-monophosphate in rat liver and Morris hepatomas.
    Advances in enzyme regulation, 1974, Volume: 12

    Topics: Amidohydrolases; Animals; Aspartate Carbamoyltransferase; Carboxy-Lyases; Carboxylic Acids; Carcinom

1974