orotic acid has been researched along with Benign Neoplasms in 27 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We demonstrated previously (Cancer Res." | 1.27 | Absence of the cancer-associated factor with a molecular weight of 60,000 from the plasma of patients with a spectrum of nonneoplastic conditions. ( Hanausek-Walaszek, ME; Schumm, DE; Walaszek, Z; Webb, TE, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (92.59) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Y | 1 |
| Bai, C | 1 |
| Ruan, Y | 1 |
| Liu, M | 1 |
| Chu, Q | 1 |
| Qiu, L | 1 |
| Yang, C | 1 |
| Li, B | 1 |
| PRUSOFF, WH | 1 |
| HOLMES, WL | 1 |
| WELCH, AD | 1 |
| ROGERS, S | 1 |
| HEIDELBERGER, C | 3 |
| CHAUDHURI, NK | 2 |
| DANNEBERG, P | 1 |
| MOOREN, D | 1 |
| GRIESBACH, L | 1 |
| DUSCHINSKY, R | 1 |
| SCHNITZER, RJ | 1 |
| PLEVEN, E | 1 |
| SCHEINER, J | 1 |
| MONTAG, BJ | 1 |
| REID, E | 1 |
| KAMMEN, HO | 1 |
| HURLBERT, RB | 1 |
| BRUEMMER, NC | 1 |
| HOLLAND, JF | 2 |
| SHEEHE, PR | 1 |
| KASBEKAR, DK | 1 |
| GREENBERG, DM | 1 |
| WILCZOK, T | 1 |
| HIRAKI, K | 1 |
| KIMURA, I | 1 |
| BENNETT, LL | 1 |
| SMITHERS, D | 1 |
| WARD, CT | 1 |
| CHU, EW | 1 |
| MALMGREN, RA | 1 |
| SHIGEURA, HT | 1 |
| GORDON, CN | 1 |
| SATO, K | 1 |
| LEPAGE, GA | 1 |
| POPOVIC, DA | 1 |
| LEONARDI, A | 1 |
| PALMA, V | 1 |
| KURU, M | 1 |
| KOSAKI, G | 1 |
| HIGASI, H | 1 |
| YASUDA, S | 1 |
| OZIRI, M | 1 |
| MIURA, Y | 1 |
| MORIYAMA, A | 1 |
| WEEK, LL | 1 |
| Schumm, DE | 1 |
| Hanausek-Walaszek, ME | 1 |
| Walaszek, Z | 1 |
| Webb, TE | 1 |
| Lund, AE | 1 |
| Cadman, EC | 1 |
| Dix, DE | 1 |
| Handschumacher, RE | 1 |
| Ohnuma, T | 1 |
| Roboz, J | 1 |
| Shapiro, ML | 1 |
| Shapot, VS | 1 |
| Vornovitskaya, GI | 1 |
| Gorozhanskaya, EG | 1 |
| Davidova, SY | 1 |
| Zhubanova, AA | 1 |
| Krechetova, GD | 1 |
| Chudinova, IA | 1 |
| Hultin, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I, Open-Label, Non-Randomized, Dose-Escalating Safety, Tolerability and Pharmacokinetic Study of TAS-114 in Combination With S-1 in Patients With Advanced Solid Tumors[NCT02454062] | Phase 1 | 120 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for orotic acid and Benign Neoplasms
| Article | Year |
|---|---|
Notes on some peculiarities of enzymic processes in malignant tumours and tissues of the host.
Topics: Adenine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Catalase; Cholesterol; DNA, Neoplasm; | 1972 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Divisi | 1970 |
25 other studies available for orotic acid and Benign Neoplasms
| Article | Year |
|---|---|
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Topics: Acetyl Coenzyme A; Ammonia; Animals; Carbon; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Female; | 2019 |
Non-utilization of radioactive iodinated uracil, uridine, and orotic acid by animal tissues in vivo.
Topics: Neoplasms; Orotic Acid; Uracil; Uridine | 1953 |
Studies of the mechanism of action of urethane in initiating pulmonary adenomas in mice. II. Its relation to nucleic acid synthesis.
Topics: Adenine; Adenoma; Animals; DNA; Lung Neoplasms; Mice; Neoplasms; Nucleic Acids; Orotic Acid; Pyrimid | 1957 |
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.
Topics: Halogenation; Neoplasms; Orotic Acid; Pyrimidines; Uracil | 1957 |
Studies on fluorinated pyrimidines. III. The metabolism of 5-fluorouracil-2-C14 and 5-fluoroorotic-2-C14 acid in vivo.
Topics: Antineoplastic Agents; Fluorides; Fluorouracil; Humans; Neoplasms; Orotic Acid; Pyrimidines | 1958 |
Incorporation of orotic acid into ribonucleotides and ribonucleic acid by liver tumours.
Topics: Liver Neoplasms; Neoplasms; Nucleosides; Nucleotides; Orotic Acid; Ribonucleotides; RNA | 1958 |
The formation of cytidine nucleotides and RNA cytosine from orotic acid by the Novikoff tumor in vitro.
Topics: Cytidine; Cytosine; In Vitro Techniques; Neoplasms; Nucleosides; Nucleotides; Orotic Acid; Pyrimidin | 1959 |
Drug effects on a target metabolic pathway and on mouse tumor growth: azauridine and decarboxylation of orotic acid-7-C-14.
Topics: Animals; Azauridine; Decarboxylation; Metabolic Networks and Pathways; Mice; Neoplasms; Neoplasms, E | 1962 |
STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Fluorouracil; Genetics; Lymphoma; Lymphoma, Non-Hodgkin; M | 1963 |
STUDIES ON THE INCORPORATION OF HETEROLOGOUS RNA INTO NEOPLASTIC CELLS.
Topics: Animals; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Metabolism; Mice; Neoplasms; Orotic A | 1963 |
STUDIES ON THE TREATMENT OF MALIGNANT TUMORS WITH FIBROBLAST-INHIBITING AGENT. I. FIBROBLAST-INHIBITING ACTION OF CHLOROQUINE.
Topics: Antineoplastic Agents; Chick Embryo; Chloroquine; Chondroitin; Connective Tissue; Fibroblasts; Granu | 1963 |
INHIBITION OF DNA SYNTHESIS IN MAMMALIAN CELLS BY ACTIDIONE.
Topics: Adenine; Adenine Nucleotides; Anti-Bacterial Agents; Aspartic Acid; Carbon Isotopes; Carcinoma, Squa | 1964 |
EFFECT OF OROTIC ACID ON THE METASTASIS OF MAMMARY TUMORS IN MICE.
Topics: Animals; Breast Neoplasms; Carcinogens; Humans; Lung Neoplasms; Mammary Neoplasms, Animal; Mammary N | 1964 |
THE EFFECTS OF 3'-DEOXYADENOSINE ON THE SYNTHESIS OF RIBONUCLEIC ACID.
Topics: Adenine; Adenosine Triphosphate; Antimetabolites; Antineoplastic Agents; Carbon Isotopes; Carcinoma, | 1965 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neopla | 1965 |
[ANTIBIOTICS AS INHIBITORS OF RNA BIOSYNTHESIS IN NEOPLASTIC TISSUE. INCORPORATION OF 2-C-14 OROTIC ACID INTO THE RNA OF EHRLICH CARCINOMA IN VARIOUS CONCENTRATIONS OF ACTINOMYCIN D].
Topics: Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma; Carcinoma, Ehrlich Tumor; Dactinomycin; | 1964 |
[Activity of fluorinated pyrimidines on the growth of human tumor cells cultured in vitro].
Topics: Biological Phenomena; Halogenation; In Vitro Techniques; Neoplasms; Nucleosides; Nucleotides; Orotic | 1959 |
The effect of oncotrephin upon incorporation of 14C-orotic acid into RNA of normal liver slices in vitro.
Topics: In Vitro Techniques; Liver; Neoplasms; Orotic Acid; RNA | 1961 |
Studies on the metabolism of rat ascites tumor with nitrogen mustard sensitive and resistant strains. VI. Inhibition of the in vitro incorporation of C-14-orotic acid into nucleic acids by nitrogen mustard.
Topics: Animals; Ascites; DNA; In Vitro Techniques; Mechlorethamine; Neoplasms; Nitrogen Mustard Compounds; | 1961 |
The incorporation of radioactive orotic acid into the nucleic acid pyrimidines of animal and human tumors.
Topics: Animals; Humans; Neoplasms; Nucleic Acids; Orotic Acid; Pyrimidines | 1951 |
Absence of the cancer-associated factor with a molecular weight of 60,000 from the plasma of patients with a spectrum of nonneoplastic conditions.
Topics: Adult; Aged; Amniotic Fluid; Animals; Biological Assay; Blood Proteins; Electrophoresis, Polyacrylam | 1984 |
Quick cancer test developed.
Topics: Allopurinol; Antimetabolites; Biomarkers, Tumor; DNA; Humans; Neoplasms; Orotic Acid; Pyrimidines; U | 1998 |
Clinical, biological, and biochemical effect of pyrazofurin.
Topics: Adolescent; Adult; Aged; Amides; Animals; Carcinoma 256, Walker; Cell Division; Cell Line; Female; H | 1978 |
Pharmacological and biochemical effects of pyrazofurin in humans.
Topics: Amides; Antibiotics, Antineoplastic; Drug Administration Schedule; Female; Half-Life; Humans; Infusi | 1977 |
The early interference of liver carcinogens with protein synthesis and its possible bearing on the problem of tumor induction.
Topics: Acridines; Animals; Carbon Isotopes; Carbon Tetrachloride; Carcinogens; Centrifugation, Density Grad | 1971 |