orotic acid has been researched along with Alloxan Diabetes in 17 studies
Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since these phenomena were not associated with enhanced biosynthesis of orotate de novo, the increased glomerular UDP-sugar bioavailability in diabetes is due to enhanced utilization of exogenous orotate." | 1.27 | Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake. ( Cortes, P; Dumler, F; Levin, NW; Paielli, DL, 1988) |
| " Studies were designed to assess the bioavailability of 5-phosphoribosyl-1-pyrophosphate (PRPP) in the diabetic renal cortex because PRPP is an important determinant of the de novo synthesis of nucleotides." | 1.26 | Phosphoribosylpyrophosphate bioavailability in diabetic rat renal cortex in vivo. ( Cortes, P; Levin, NW; Schoenberger, AM; Venkatachalam, KK; Verghese, CP, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (94.12) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Verma, H | 1 |
| Garg, R | 1 |
| SCHWARZ-TIENE, E | 1 |
| CAREDDU, P | 1 |
| CABASSA, N | 1 |
| WEBER, G | 1 |
| SINGHAL, RL | 1 |
| SRIVASTAVA, SK | 1 |
| Cortes, P | 5 |
| Verghese, CP | 2 |
| Venkatachalam, KK | 3 |
| Schoenberger, AM | 1 |
| Levin, NW | 5 |
| Tornello, S | 1 |
| Fridman, O | 1 |
| Weisenberg, L | 1 |
| Coirini, H | 1 |
| De Nicola, AF | 1 |
| Dumler, F | 4 |
| Goldman, J | 2 |
| Sastry, KS | 1 |
| Venkatachalam, H | 1 |
| Bernstein, J | 1 |
| Spargo, BH | 2 |
| Minchenko, AG | 2 |
| Germanyuk, YL | 1 |
| Rubenstein, AH | 1 |
| Paielli, DL | 1 |
| Motyl, T | 1 |
| Debski, B | 1 |
| Hanoune, J | 1 |
| Chambaut, AM | 1 |
| Rüstow, B | 1 |
| Lindigkeit, R | 1 |
| Schmidt, R | 2 |
| Methfessel, J | 2 |
| Schultka, R | 1 |
| Apel, D | 1 |
| Steiner, DF | 1 |
| King, J | 1 |
| Keil, S | 1 |
17 other studies available for orotic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia.
Topics: Animals; Cholecalciferol; Diabetes Mellitus, Experimental; Disease Models, Animal; Dyslipidemias; Hy | 2020 |
[Modifications of high-energy phosphate compounds in experimental galactosuric diabetes and protective action of orotic acid].
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Galactose; Nutrition Assessment; Nutritional Status; | 1959 |
INSULIN: SUPPRESSOR OF BIOSYNTHESIS OF HEPATIC GLUCONEOGENIC ENZYMES.
Topics: Animals; Blood Glucose; Dactinomycin; Diabetes Mellitus, Experimental; Enzyme Repression; Ethionine; | 1965 |
Phosphoribosylpyrophosphate bioavailability in diabetic rat renal cortex in vivo.
Topics: Adenine; Adenosine Triphosphate; Animals; Biological Availability; Diabetes Mellitus, Experimental; | 1980 |
Differences in corticosterone binding by regions of the central nervous system in normal and diabetic rats.
Topics: Adrenalectomy; Animals; Betaine; Brain; Cerebral Cortex; Corticosterone; Diabetes Mellitus, Experime | 1981 |
Alterations in glomerular RNA in diabetic rats: roles of glucagon and insulin.
Topics: Adenine; Animals; Biotransformation; Diabetes Mellitus, Experimental; Glucagon; Glucose; Insulin; Ki | 1981 |
Glomerular pyrimidine metabolism in experimental diabetic nephropathy.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; DNA; Kidney Cortex; Kidney Glomerulus; | 1980 |
Effect of hydrocortisone on the expression of mitochondrial genes in the liver of normal and alloxan diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; DNA; Gene Expression Regulation; Hydrocortisone; Male; Mit | 1984 |
Effect of insulin on RNA and protein biosynthesis in liver mitochondria from normal and alloxan diabetic rats.
Topics: Animals; Cytoplasm; Diabetes Mellitus, Experimental; DNA; Insulin; Leucine; Male; Mitochondria, Live | 1978 |
Effects of orotate administration on the normal rat kidney: similarity to changes observed in diabetes mellitus.
Topics: Animals; Basement Membrane; Diabetes Mellitus, Experimental; DNA; Glucagon; Kidney Cortex; Kidney Gl | 1979 |
Glomerular uracil nucleotide synthesis: effects of diabetes and protein intake.
Topics: Animals; Diabetes Mellitus, Experimental; Dietary Proteins; Kidney Glomerulus; Kinetics; Male; Oroti | 1988 |
The urinary excretion of orotic acid in diabetic rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Orotic Acid; Rabbits | 1988 |
Early responses of liver to cortisone in alloxan-diabetic rats.
Topics: Animals; Carbon Isotopes; Cortisone; Diabetes Mellitus, Experimental; Fasting; Leucine; Liver; Liver | 1972 |
[Effect of insulin on the in-vitro RNA-synthesis of liver cell nuclei in normal and alloxan-diabetic rats].
Topics: Animals; Blood Glucose; Cell Fractionation; Cell Nucleus; Diabetes Mellitus, Experimental; In Vitro | 1974 |
[Morphological and biochemical studies of the effect of barbituric acid, ureidosuccinic acid, orotic acid, uracil and thymine on the diabetogenic effect of alloxan].
Topics: Adrenal Glands; Alloxan; Amino Alcohols; Animals; Barbiturates; Blood Glucose; Diabetes Mellitus, Ex | 1968 |
Insulin-stimulated ribonucleic acid synthesis and RNA polymerase activity in alloxan-diabetic rat liver.
Topics: Animals; Diabetes Mellitus, Experimental; Insulin; Liver; Nucleotidyltransferases; Orotic Acid; Puro | 1966 |
[On the effect of pyrimidines and their precursors on the diabetogenic activity of alloxan].
Topics: Alloxan; Animals; Aspartic Acid; Barbiturates; Blood Glucose; Cytosine; Diabetes Mellitus, Experimen | 1966 |