orotic acid and Aging studies

Orotic Acid: An intermediate product in PYRIMIDINE synthesis which plays a role in chemical conversions between DIHYDROFOLATE and TETRAHYDROFOLATE.
orotic acid : A pyrimidinemonocarboxylic acid that is uracil bearing a carboxy substituent at position C-6.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
"Nicergoline (NE)--a cerebral vasodilator with nicotinic acid esterified in its molecule--and Antagonic-Stress (AS) composition--a neurometabolic nootropic, also containing nicotinic acid but with fast and prolonged release--were evaluated in senile dementia of Alzheimer's type (SDAT), mild to moderate intensity (DSM-IV Options Book, 1991 and ICD-10, 1990 criteria)."	5.07	Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry. ( Mateescu, R; Măties, R; Mihalas, G; Mihalas, IG; Popa, R; Schneider, F; Stefanigă, P, 1994)
" The method was used to measure orotic acid and orotidine in urine samples from newborns, healthy controls and patients with gout or deficiency of hypoxanthine-guanine phosphoribosyltransferase receiving allopurinol."	3.66	The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay. ( Schretlen, ED; Tax, WJ; Veerkamp, JH, 1978)
"Thymidine was not phosphorylated, and was believed to be catabolized."	1.25	Uptake of orotate and thymidine by normal and regenerating rat livers. ( Ord, MG; Stocken, LA, 1973)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (83.72)	18.7374
1990's	5 (11.63)	18.2507
2000's	2 (4.65)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Rosenfeldt, F	1
Miller, F	1
Nagley, P	1
Hadj, A	1
Marasco, S	1
Quick, D	1
Sheeran, F	1
Wowk, M	1
Pepe, S	1
Ravina, A	1
Sacher, JA	1
Muradjan, CK	1
Martin, H	3
Martin, R	3
Yamagami, S	1
Ohno, K	1
Tsuji, M	1
Mori, K	1
Kawakita, Y	1
Mozzhukhina, TG	1
Khilobok, IIu	1
Gol'dshtein, NB	1
Richardson, A	2
Birchenall-Sparks, MC	1
Staecker, JL	1
Hardwick, JP	1
Liu, DS	2
Rüthrich, HL	1
Wetzel, W	1
Matthies, H	1
Srivastava, US	1
Majumdar, PK	1
Thakur, ML	1
Nagasaki, T	1
Robinson, JL	2
Drabik, MR	1
Dombrowski, DB	1
Clark, JH	1
Harden, KK	1
Haan, EA	1
Danks, DM	1
Grimes, A	1
Hoogenraad, NJ	1
Neumeister, JA	1
Webster, GC	1
Costello, MJ	1
Morris, JG	2
Rogers, QR	1
McCann, MT	1
Thompson, MM	1
Gueron, IC	1
Tuchman, M	2
Predescu, V	1
Riga, D	1
Riga, S	1
Turlea, J	1
Bărbat, IM	1
Botezat-Antonescu, L	1
Schneider, F	1
Popa, R	1
Mihalas, G	1
Stefanigă, P	1
Mihalas, IG	1
Măties, R	1
Mateescu, R	1
Morishita, K	1
Shirai, A	1
Kubota, M	1
Katakura, Y	1
Nabeshima, Y	1
Takeshige, K	1
Kamiya, T	1
Tax, WJ	1
Veerkamp, JH	1
Schretlen, ED	1
Kreamer, W	1
Zorich, N	1
Hassan, AS	1
Milner, JA	2
Visek, WJ	1
Tremblay, GC	1
Jimenez, U	1
Crandall, DE	1
Dainat, J	1
Rebière, A	1
Burlina, AB	1
Ferrari, V	1
Dionisi-Vici, C	1
Bordugo, A	1
Zacchello, F	1
Gross, KL	1
Hartman, WJ	1
Ronnenberg, A	1
Prior, RL	1
Engelbrecht, C	1
Yngner, T	1
Gushiken, T	1
Yoshimura, N	1
Saheki, T	1
Birkmayer, W	1
Rosmanith, H	1
Miyamoto, M	1
Terayama, H	1
Shearer, RW	1
Soto, AM	2
Duvilanski, BH	2
De Guglielmone, AR	1
Gómez, CJ	1
Ord, MG	1
Stocken, LA	1
De Guglielmone, AE	1
Seemayer, G	1
Menzies, RA	1
Gold, PH	1
Mitznegg, P	1
Heim, F	1
Hach, B	1
Säbel, M	1
Spadoni, MA	1
Ticca, M	1

Article	Year
Antagonic-stress. A new treatment in gerontopsychiatry and for a healthy productive life. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aged; Aging; Cognition Disorders; Double-Blind Method; Drug Combinations; Female; Humans; Male; Mecl	1994
Superiority of antagonic-stress composition versus nicergoline in gerontopsychiatry. Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717 Topics: Aged; Aging; Dementia; Double-Blind Method; Drug Combinations; Female; Geriatric Assessment; Humans;	1994

Article	Year
Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age. Annals of the New York Academy of Sciences, 2004, Volume: 1019 Topics: Aging; Clinical Trials as Topic; Coenzymes; DNA, Mitochondrial; Exercise; Fatty Acids, Omega-3; Fatt	2004
[Some considerations on the pathogenesis and treatment of aging]. La Presse medicale, 1967, Apr-08, Volume: 75, Issue:17 Topics: Aged; Aging; Animals; Dogs; Female; Humans; Male; Orotic Acid; Sulfadiazine; Sulfamethoxypyridazine;	1967
Studies of permeability, RNA and protein turnover during ageing of fruit and leaf tissues. Symposia of the Society for Experimental Biology, 1967, Volume: 21 Topics: Aging; Cell Membrane Permeability; Dactinomycin; Fruit; Leucine; Orotic Acid; Plant Growth Regulator	1967
[Molecularbiology of ageing. 20th report: RNA-metabolism and aging--relations between pool of precursors and labelling of nuclear RNA-fractions (author's transl)]. Zeitschrift fur Alternsforschung, 1980, Volume: 35, Issue:2 Topics: Aging; Animals; Cytidine Monophosphate; Female; Liver; Orotic Acid; Pyrimidine Nucleotides; Rats; RN	1980
[RNA-metabolism in aging (author's transl)]. Zeitschrift fur Alternsforschung, 1980, Volume: 35, Issue:1 Topics: Aging; Animals; Carbon Radioisotopes; DNA; Intestinal Mucosa; Kidney; Liver; Muscles; Myocardium; Or	1980
Developmental alteration in RNA metabolism of E1 mouse brain. Folia psychiatrica et neurologica japonica, 1981, Volume: 35, Issue:3 Topics: Aging; Animals; Brain; DNA; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Tissue Protein	1981
[Incorporation of [2-14C orotic] acid into chromatin RNA of tissues of animals of various ages]. Ukrainskii biokhimicheskii zhurnal (1978), 1982, Volume: 54, Issue:1 Topics: Aging; Animals; Carbon Radioisotopes; Chromatin; Intestinal Mucosa; Intestine, Small; Liver; Orotic	1982
The transcription of various types of ribonucleic acid by hepatocytes isolated from rats of various ages. Journal of gerontology, 1982, Volume: 37, Issue:6 Topics: Age Factors; Aging; Animals; Female; In Vitro Techniques; Liver; Orotic Acid; Rats; Rats, Inbred F34	1982
Memory retention in old rats: improvement by orotic acid. Psychopharmacology, 1983, Volume: 79, Issue:4 Topics: Aging; Animals; Avoidance Learning; Discrimination, Psychological; Light; Male; Memory; Orotic Acid;	1983
Brain mRNA translatability in rats: changes during long-term dietary restriction in the developmental period of life. The Journal of nutrition, 1984, Volume: 114, Issue:12 Topics: Aging; Animals; Autoradiography; Body Weight; Brain; Female; Food Deprivation; Orotic Acid; Poly A;	1984
[Ammonia metabolism during perinatal period--ontogenesis of enzymes in pyrimidine biosynthesis and urea cycle system]. Nihon Sanka Fujinka Gakkai zasshi, 1984, Volume: 36, Issue:12 Topics: Aging; Ammonia; Animals; Animals, Newborn; Aspartate Carbamoyltransferase; Carbamoyl-Phosphate Synth	1984
Consequences of UMP synthase deficiency in cattle. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:2 Topics: Aging; Animals; Animals, Newborn; Carboxy-Lyases; Cattle; Female; Male; Milk; Multienzyme Complexes;	1983
Hypocholesteremia induced by orotic acid: dietary effects and species specificity. The Journal of nutrition, 1984, Volume: 114, Issue:2 Topics: Aging; Animals; Cholesterol; Cholesterol, Dietary; Cricetinae; Diet; Dietary Carbohydrates; Dietary	1984
Carrier detection in ornithine transcarbamylase deficiency. Journal of inherited metabolic disease, 1982, Volume: 5, Issue:1 Topics: Adolescent; Adult; Aging; Ammonia; Child; Duodenum; Female; Genetic Carrier Screening; Humans; Ornit	1982
Changes in the levels and the rate of synthesis of transfer RNA in tissues of mice of different ages. Mechanisms of ageing and development, 1981, Volume: 16, Issue:4 Topics: Aging; Animals; Female; Kidney; Liver; Mice; Mice, Inbred C57BL; Muscles; Myocardium; Orotic Acid; R	1981
Effect of dietary arginine level on urinary orotate and citrate excretion in growing kittens. The Journal of nutrition, 1980, Volume: 110, Issue:6 Topics: Aging; Animals; Arginine; Cats; Citrates; Diet; Dose-Response Relationship, Drug; Female; Male; Nutr	1980
Quantification of orotic acid in dried filter-paper urine samples by stable isotope dilution. Clinical chemistry, 1995, Volume: 41, Issue:5 Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Creatinine; Gas Chromatography-Mass Spectrometry;	1995
The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc. The Journal of nutrition, 2001, Volume: 131, Issue:12 Topics: Aging; Animals; Blotting, Western; Female; Glucuronidase; Homozygote; Klotho Proteins; Male; Membran	2001
[RNA metabolism and ageing (author's transl)]. Aktuelle Gerontologie, 1977, Volume: 7, Issue:5 Topics: Age Factors; Aging; Animals; Cell Nucleus; Female; Hydrocortisone; Intestinal Mucosa; Kidney; Liver;	1977
The urinary excretion of orotic acid and orotidine, measured by an isotope dilution assay. Clinica chimica acta; international journal of clinical chemistry, 1978, Dec-15, Volume: 90, Issue:3 Topics: Adolescent; Adult; Aging; Allopurinol; Breast Feeding; Child; Female; Gout; Humans; Hypoxanthine Pho	1978
Effect of age on RNA synthesis by rat hepatocytes. Experimental gerontology, 1979, Volume: 14, Issue:1 Topics: Aging; Animals; Liver; Male; Orotic Acid; Rats; Ribonucleotides; RNA; Uridine Triphosphate	1979
Orotic aciduria and increased nitrogen catabolism in rats. The Journal of nutrition, 1979, Volume: 109, Issue:11 Topics: Aging; Animals; Arginine; Dietary Proteins; Male; Nitrogen; Orotic Acid; Purine-Pyrimidine Metabolis	1979
Orotic aciduria in the female rat and its relation to dietary arginine. The Journal of nutrition, 1978, Volume: 108, Issue:8 Topics: Aging; Ammonia; Animals; Arginine; Birth Weight; Body Weight; Citrates; Female; Litter Size; Orotic	1978
Pyrimidine biosynthesis and its regulation in the developing rat brain. Journal of neurochemistry, 1976, Volume: 26, Issue:1 Topics: Aging; Animals; Animals, Newborn; Aspartic Acid; Azauridine; Bicarbonates; Brain; Female; Fetus; Mal	1976
[The change on the incorporation of (6-14C)orotic acid in vivo into RNA and DNA in the cerebellum of young hypo- and hyperthyroid rats: comparative effects of hypo- and hyperthyroidism on cell multiplication (author's transl)]. Journal of neurochemistry, 1976, Volume: 26, Issue:5 Topics: Aging; Animals; Animals, Newborn; Cell Division; Cerebellum; DNA Replication; Hyperthyroidism; Hypot	1976
Allopurinol challenge test in children. Journal of inherited metabolic disease, 1992, Volume: 15, Issue:5 Topics: Adolescent; Aging; Allopurinol; Child; Child, Preschool; Citrulline; Female; Humans; Infant; Male; M	1992
Arginine-deficient diets alter plasma and tissue amino acids in young and aged rats. The Journal of nutrition, 1991, Volume: 121, Issue:10 Topics: Aging; Amino Acids; Ammonia; Animals; Arginine; Diet; Liver; Male; Orotic Acid; Rats; Rats, Inbred S	1991
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice. The International journal of biochemistry, 1985, Volume: 17, Issue:4 Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine	1985
Nutritional and metabolic responses to arginine deficiency in carnivores. The Journal of nutrition, 1985, Volume: 115, Issue:4 Topics: Aging; Animal Nutritional Physiological Phenomena; Animals; Arginine; Carnivora; Cats; Citrulline; D	1985
Transient hyperammonemia during aging in ornithine transcarbamylase-deficient, sparse-fur mice. Biochemistry international, 1985, Volume: 11, Issue:5 Topics: Aging; Ammonia; Animals; Body Weight; Disease Models, Animal; Hair; Liver; Mice; Mice, Mutant Strain	1985
[Verification of gerontotherapeutic effects. (Clinical experimental study on Kavaform)]. Munchener medizinische Wochenschrift (1950), 1971, Mar-12, Volume: 113, Issue:11 Topics: Adult; Aged; Aging; Emotions; Female; Flicker Fusion; Follow-Up Studies; Humans; Male; Memory; Middl	1971
Tumor cell sap factor stimulating orotate incorporation into nucleic acids in ascites hepatoma cells. Biochimica et biophysica acta, 1972, Jul-31, Volume: 272, Issue:4 Topics: Aging; Animals; Animals, Newborn; Carbon Isotopes; Carcinoma, Hepatocellular; Cytoplasm; Diphosphate	1972
Irreversibility of the alteration in RNA transport induced by an azo-dye carcinogen in the rat liver. Biochemical and biophysical research communications, 1974, Apr-08, Volume: 57, Issue:3 Topics: Aging; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; DNA, Neopl	1974
Precursors for RNA synthesis and their metabolism in developing rat brain. Neurobiology, 1974, Volume: 4, Issue:5 Topics: Aging; Animals; Brain; Cell Fractionation; Cell Nucleus; Chromatography, Thin Layer; Female; Guanine	1974
Uptake of orotate and thymidine by normal and regenerating rat livers. The Biochemical journal, 1973, Volume: 132, Issue:1 Topics: Aging; Animals; Biological Transport, Active; Body Weight; Chromatography, Thin Layer; Hepatectomy;	1973
Neonatal undernutrition and RNA synthesis in developing rat brain. Journal of neurochemistry, 1974, Volume: 22, Issue:4 Topics: Aging; Animals; Body Weight; Brain; Cell Nucleus; Chromatography, Thin Layer; Deficiency Diseases; D	1974
Methylation of DNA in vivo by thymus, spleen, and liver of the rat. Biochimica et biophysica acta, 1970, Nov-12, Volume: 224, Issue:1 Topics: Aging; Aminopterin; Animals; Animals, Newborn; Brucella abortus; Carbon Isotopes; Chromatography, Pa	1970
The apparent turnover of mitochondria, ribosomes and sRNA of the brain in young adult and aged rats. Journal of neurochemistry, 1972, Volume: 19, Issue:7 Topics: Aging; Animals; Brain; Carbon Isotopes; Cell Fractionation; Half-Life; Kinetics; Leucine; Male; Mito	1972
The effect of ageing, caffeine-treatment, and ionizing-radiation on nucleic acid synthesis in the mouse liver. Life sciences. Pt. 2: Biochemistry, general and molecular biology, 1971, Nov-22, Volume: 10, Issue:22 Topics: Aging; Animals; Caffeine; Carbon Isotopes; DNA; Hepatectomy; Liver; Liver Regeneration; Male; Mice;	1971
Effect of the administration of xanthine on the appearance of xanthine oxidase activity in the liver of growing rats. Experientia, 1968, Sep-15, Volume: 24, Issue:9 Topics: Aging; Animals; Carbon Isotopes; Cortisone; Cycloheximide; Dactinomycin; Leucine; Liver; Orotic Acid	1968

orotic acid and Aging

Research Excerpts

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