ornithylamphotericin-methyl-ester has been researched along with Histoplasmosis* in 1 studies
1 other study(ies) available for ornithylamphotericin-methyl-ester and Histoplasmosis
Article | Year |
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In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester.
N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB. Topics: Adjuvants, Immunologic; Amphotericin B; Animals; Antifungal Agents; Female; Histoplasma; Histoplasmosis; Mice; Mice, Inbred AKR; Microbial Sensitivity Tests | 1985 |