Compounds > ornithylamphotericin-methyl-ester

ornithylamphotericin-methyl-ester and Histoplasmosis

ornithylamphotericin-methyl-ester has been researched along with Histoplasmosis* in 1 studies

Other Studies

1 other study(ies) available for ornithylamphotericin-methyl-ester and Histoplasmosis

Article	Year
In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester. Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:3 N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB. Topics: Adjuvants, Immunologic; Amphotericin B; Animals; Antifungal Agents; Female; Histoplasma; Histoplasmosis; Mice; Mice, Inbred AKR; Microbial Sensitivity Tests	1985

Article

Year

In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester.

Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:3

N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB.

Topics: Adjuvants, Immunologic; Amphotericin B; Animals; Antifungal Agents; Female; Histoplasma; Histoplasmosis; Mice; Mice, Inbred AKR; Microbial Sensitivity Tests

1985