ornithine and Trypanosomiasis, African

ornithine has been researched along with Trypanosomiasis, African in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (85.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (15.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Alsford, S; Currier, RB; Horn, D; Macedo, JP; Rentsch, D; Wirdnam, C	1
Barrett, MP; Christianson, DW; Hai, Y; Kerkhoven, EJ	1
Gilbert, D; Gu, X; Higham, DJ; Reid, D	1
Amole, BO; Bacchi, CJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Seed, JR; Sjoerdsma, A	1
Bacchi, CJ; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A	2
Bacchi, CJ; Chunosoff, L; Diekema, KA; Garofalo, J; Hutner, SH; McCann, PP; Mockenhaupt, D; Mullaney, EA; Nathan, HC; Pegg, AE; Sjoerdsma, A	1
Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A	1
Bacchi, CJ; Hanson, WL; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A	1
Schechter, PJ; Sjoerdsma, A	1
de Gee, AL; Mansfield, JM; McCann, PP	1
Bacchi, CJ; Bienen, EJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A	1
Carstens, PH; de Gee, AL; Mansfield, JM; McCann, PP	1
Barlow, JL; Golden, JA; Santi, DV; Schechter, PJ; Sjoerdsma, A	1
Bacchi, CJ; Hutner, SH; McCann, PP; Nathan, HC; Rescigno, D; Sjoerdsma, A	1
Böttger, M; Freitas, EK; Karbe, E; McCann, PP; Sjoerdsma, A	1
Bitonti, AJ; McCann, PP; Sjoerdsma, A	1
Bacchi, CJ; Bitonti, AJ; McCann, PP; Sjoerdsma, A	1
Boné, G; Burke, J; Declercq, J; Schechter, PJ; Sjoerdsma, A; Van Nieuwenhove, S	1
Bourgeade, A; Faugere, B; Nosny, Y; Pene, P	1

Reviews

1 review(s) available for ornithine and Trypanosomiasis, African

Article	Year
Chemotherapeutic implications of polyamine biosynthesis inhibition. Clinical pharmacology and therapeutics, 1984, Volume: 35, Issue:3 Topics: Animals; Drug Evaluation; Eflornithine; Female; Humans; Male; Melanoma; Mice; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protozoan Infections; Trypanosomiasis, African	1984

Trials

1 trial(s) available for ornithine and Trypanosomiasis, African

Article	Year
Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Volume: 79, Issue:5 Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child; Clinical Trials as Topic; Eflornithine; Female; Humans; Leukocyte Count; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Sudan; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1985

Article

Year

Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985, Volume: 79, Issue:5

Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child; Clinical Trials as Topic; Eflornithine; Female; Humans; Leukocyte Count; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Sudan; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African

1985

Other Studies

18 other study(ies) available for ornithine and Trypanosomiasis, African

Article	Year
Ornithine uptake and the modulation of drug sensitivity in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017, Volume: 31, Issue:10 Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase; Polyamines; Trypanosoma brucei brucei; Trypanosomiasis, African	2017
Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster. Biochemistry, 2015, Jan-20, Volume: 54, Issue:2 Topics: Amino Acid Sequence; Arginase; Arginine; Crystallography, X-Ray; Humans; Manganese; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Ornithine; Protein Conformation; Protozoan Proteins; Sequence Alignment; Trypanosoma brucei brucei; Trypanosomiasis, African	2015
Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification. PloS one, 2013, Volume: 8, Issue:1 Topics: Adenosylmethionine Decarboxylase; Animals; Computer Simulation; Eflornithine; Humans; Kinetics; Metabolic Networks and Pathways; Models, Chemical; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; S-Adenosylmethionine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2013
Further studies on difluoromethylornithine in African trypanosomes. Medical biology, 1981, Volume: 59, Issue:5-6 Topics: Acute Disease; Animals; Arvicolinae; Bleomycin; Carboxy-Lyases; Central Nervous System Diseases; Chronic Disease; Drug Therapy, Combination; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosomiasis, African	1981
Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines. Biochemical pharmacology, 1982, Sep-01, Volume: 31, Issue:17 Topics: Animals; Bleomycin; Drug Therapy, Combination; Eflornithine; Mice; Ornithine; Polyamines; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African	1982
In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei. Molecular and biochemical parasitology, 1983, Volume: 7, Issue:3 Topics: Animals; DNA; Eflornithine; Female; Kinetics; Macromolecular Substances; Ornithine; Polyamines; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA; Trypanosoma brucei brucei; Trypanosomiasis, African	1983
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis. Proceedings of the National Academy of Sciences of the United States of America, 1983, Volume: 80, Issue:18 Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Female; Male; Mice; Ornithine; Spermidine; Spermine; Trypanocidal Agents; Trypanosomiasis, African	1983
Methods for the study of the treatment of protozoan diseases by inhibitors of ornithine decarboxylase. Methods in enzymology, 1983, Volume: 94 Topics: Animals; Chickens; Coccidiosis; Eflornithine; Female; Male; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Protozoan Infections; Trypanosomiasis, African	1983
Role of antibody in the elimination of trypanosomes after DL-alpha-difluoromethylornithine chemotherapy. The Journal of parasitology, 1983, Volume: 69, Issue:5 Topics: Animals; Antibodies; Antibody Formation; Antigens, Surface; Cyclophosphamide; Eflornithine; Immunosuppression Therapy; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Ornithine; Recurrence; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	1983
New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin. The American journal of tropical medicine and hygiene, 1984, Volume: 33, Issue:6 Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Humans; Injections, Intravenous; Mice; Ornithine; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African	1984
Morphological changes in Trypanosoma brucei rhodesiense following inhibition of polyamine biosynthesis in vivo. Tissue & cell, 1984, Volume: 16, Issue:5 Topics: Animals; Eflornithine; Erythrocytes; Mice; Mice, Inbred Strains; Microscopy, Electron; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Trypanosoma; Trypanosomiasis, African	1984
Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine. Transactions of the Association of American Physicians, 1984, Volume: 97 Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Pneumonia, Pneumocystis; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	1984
Polyamine metabolism: a potential therapeutic target in trypanosomes. Science (New York, N.Y.), 1980, Oct-17, Volume: 210, Issue:4467 Topics: Animals; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1980
Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections. Biochemical pharmacology, 1981, Nov-01, Volume: 30, Issue:21 Topics: Animals; Eflornithine; Female; Male; Mice; Ornithine; Polyamines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1981
Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice. Tropenmedizin und Parasitologie, 1982, Volume: 33, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Eflornithine; Female; Muridae; Ornithine; Trypanocidal Agents; Trypanosomiasis, African	1982
Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine. Biochemical pharmacology, 1986, Jan-15, Volume: 35, Issue:2 Topics: Animals; Antibody Formation; Antigens, Protozoan; Dexamethasone; Eflornithine; Immunity; Immunosuppression Therapy; Male; Organ Size; Ornithine; Rats; Spleen; Thymus Gland; Trypanosomiasis, African	1986
Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis. Biochemical pharmacology, 1985, May-15, Volume: 34, Issue:10 Topics: Animals; Eflornithine; Kinetics; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1985
[African trypanosomiasis of icterohemorrhagic form]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5 Pt 2 Topics: Eflornithine; France; Male; Ornithine; Tanzania; Travel; Trypanocidal Agents; Trypanosomiasis, African	1985