orlistat and Avitaminosis

To determine whether orlistat causes fat-soluble vitamin deficiencies in African-American and Caucasian adolescents.. Prospective, open-label pilot study.. Warren Grant Magnuson Clinical Center of the National Institutes of Health.. Seventeen adolescents with body mass indexes above the 95th percentile for age, race, and gender who also had at least one obesity-related comorbid condition.. Subjects received orlistat 120 mg 3 times/day and a daily multivitamin supplement containing vitamin A 5000 IU, vitamin D 400 IU, vitamin E 300 IU, and vitamin K 25 microg.. During 3-6 months of orlistat treatment, acute absorption of retinol (vitamin A) was not significantly altered, but absorption of alpha-tocopherol (vitamin E) was significantly reduced compared with baseline levels (p<0.001). Serum levels of vitamins A and E did not change significantly; however, there was a nonsignificant decrease in vitamin K. Mean vitamin D levels were significantly reduced compared with baseline (p<0.02) after 1 month of orlistat, despite multivitamin supplementation.. It may be prudent to monitor vitamin D concentrations in adolescents who take orlistat, even when a multivitamin is prescribed.

Topics: Adolescent; Analysis of Variance; Avitaminosis; Child; Female; Humans; Lactones; Male; Obesity; Orlistat; Pilot Projects; Prospective Studies; Vitamin A; Vitamin D; Vitamin E

Most antiobesity drugs act centrally to reduce appetite or increase satiety. Orlistat is the first in a new class of drugs targeted at a single dietary component, in this case dietary fat.. To review the clinical actions and efficacy of orlistat and to discuss its place in overall weight management.. Orlistat is best used in long term weight management as an adjunct to dietary modification and increased physical activity. The reduction in fat absorption results in a slow but sustained weight reduction and improved metabolic parameters such as reduced total, and LDL cholesterol. Side effects are minimised by maintaining a low fat diet.

Topics: Anti-Obesity Agents; Australia; Avitaminosis; Cholesterol; Humans; Lactones; Obesity; Orlistat