oripavine and Spasm

oripavine has been researched along with Spasm* in 1 studies

Other Studies

1 other study(ies) available for oripavine and Spasm

Article	Year
Synthesis and narcotic agonist-antagonist evaluation of some 2,6-methano-3-benzazocine-11 propanols. Analogues of the ring C bridged oripavine-7-mehtanols. Journal of medicinal chemistry, 1977, Volume: 20, Issue:5 A general synthesis of variously substituted 2,6-methano-3-benzazocine-11-propanols is described. Nine N-CH3 derivatives and their corresponding N-cyclopropylmethyl counterparts were prepared and studied in the mouse acetylcholine induced writhing and rat phenazocine antagonism tests. The results are compared with literature information on the bridged oripavine methanols. It is concluded that the synthetic analogues have a different structure-activity profile, in general being weak agonists but potent antagonists. Topics: Acetylcholine; Analgesics, Opioid; Animals; Azocines; Mice; Molecular Conformation; Narcotic Antagonists; Phenazocine; Rats; Spasm; Structure-Activity Relationship; Thebaine	1977

Article

Year

Synthesis and narcotic agonist-antagonist evaluation of some 2,6-methano-3-benzazocine-11 propanols. Analogues of the ring C bridged oripavine-7-mehtanols.

Journal of medicinal chemistry, 1977, Volume: 20, Issue:5

A general synthesis of variously substituted 2,6-methano-3-benzazocine-11-propanols is described. Nine N-CH3 derivatives and their corresponding N-cyclopropylmethyl counterparts were prepared and studied in the mouse acetylcholine induced writhing and rat phenazocine antagonism tests. The results are compared with literature information on the bridged oripavine methanols. It is concluded that the synthetic analogues have a different structure-activity profile, in general being weak agonists but potent antagonists.

Topics: Acetylcholine; Analgesics, Opioid; Animals; Azocines; Mice; Molecular Conformation; Narcotic Antagonists; Phenazocine; Rats; Spasm; Structure-Activity Relationship; Thebaine

1977