oridonin and Triple-Negative-Breast-Neoplasms

oridonin has been researched along with Triple-Negative-Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for oridonin and Triple-Negative-Breast-Neoplasms

Article	Year
Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer. Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15 Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic breast cancers without safe and effective therapeutic drugs. The natural product oridonin is reported to be a potential anti-TNBC agent. However, its moderate activity and complex structure hampered its clinical application. In this study, the novel oridonin analogues were first identified by removal of multiple hydroxyl groups and structural simplification of oridonin. The representative analogue Topics: Animals; Cell Line, Tumor; Diterpenes, Kaurane; Humans; Male; Mice; Mice, Inbred ICR; Mice, Nude; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays	2020

Article

Year

Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer.

Journal of medicinal chemistry, 2020, 08-13, Volume: 63, Issue:15

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic breast cancers without safe and effective therapeutic drugs. The natural product oridonin is reported to be a potential anti-TNBC agent. However, its moderate activity and complex structure hampered its clinical application. In this study, the novel oridonin analogues were first identified by removal of multiple hydroxyl groups and structural simplification of oridonin. The representative analogue

Topics: Animals; Cell Line, Tumor; Diterpenes, Kaurane; Humans; Male; Mice; Mice, Inbred ICR; Mice, Nude; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

2020