orfamide-a and Trypanosomiasis--African

A total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obtained, in high yield and purity. Spectral and LC-HRMS data of all library members with the isolated natural product identified the

Topics: Animals; Biological Products; Lipopeptides; Peptides, Cyclic; Trypanosoma brucei brucei; Trypanosomiasis, African