oregonin and Liver-Cirrhosis

oregonin has been researched along with Liver-Cirrhosis* in 1 studies

Other Studies

1 other study(ies) available for oregonin and Liver-Cirrhosis

Article	Year
Antifibrotic constituents of Alnus firma on hepatic stellate cells. Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10 Suppression of hepatic stellate cell (HSC) growth and activation have been proposed as therapeutic strategies for the treatment and prevention of liver fibrosis. In the course of screening antifibrotic activity of natural products, the methanolic extract of Alnus firma barks (Betulaceae) showed inhibitory activity of cell proliferation on HSC-T6 cells. A new triterpenoid characterized as lup-20(29) en-2,28-diol-3-yl caffeate (13) was isolated with 12 known diarylheptanoids (1-12) from the barks of A. firma using bioactivity-guided fractionation. Among these compounds, 2 and 13 significantly inhibited the proliferation of HSCs in dose- and time-dependent manners at concentrations from 10 to 100 μM. Taken together, antifibrotic activities of A. firma and its active constituents might suggest the therapeutic potentials against liver fibrosis. Topics: Alnus; Animals; Cell Line; Cell Proliferation; Diarylheptanoids; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Inhibitory Concentration 50; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Bark; Plant Extracts; Rats	2011

Article

Year

Antifibrotic constituents of Alnus firma on hepatic stellate cells.

Bioorganic & medicinal chemistry letters, 2011, May-15, Volume: 21, Issue:10

Suppression of hepatic stellate cell (HSC) growth and activation have been proposed as therapeutic strategies for the treatment and prevention of liver fibrosis. In the course of screening antifibrotic activity of natural products, the methanolic extract of Alnus firma barks (Betulaceae) showed inhibitory activity of cell proliferation on HSC-T6 cells. A new triterpenoid characterized as lup-20(29) en-2,28-diol-3-yl caffeate (13) was isolated with 12 known diarylheptanoids (1-12) from the barks of A. firma using bioactivity-guided fractionation. Among these compounds, 2 and 13 significantly inhibited the proliferation of HSCs in dose- and time-dependent manners at concentrations from 10 to 100 μM. Taken together, antifibrotic activities of A. firma and its active constituents might suggest the therapeutic potentials against liver fibrosis.

Topics: Alnus; Animals; Cell Line; Cell Proliferation; Diarylheptanoids; Dose-Response Relationship, Drug; Hepatic Stellate Cells; Inhibitory Concentration 50; Liver Cirrhosis; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Bark; Plant Extracts; Rats

2011