Compounds > orantinib
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orantinib and Angiogenesis, Pathologic

orantinib has been researched along with Angiogenesis, Pathologic in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's24 (88.89)29.6817
2010's3 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chu, ZH; Luo, XJ; Zeng, QL; Zhou, K1
Calderan, L; Daducci, A; Degrassi, A; Farace, P; Galiè, M; Marzola, P; Merigo, F; Nicolato, E; Pesenti, E; Sbarbati, A1
Baba, M; Hiramatsu, Y; Kamiya, K; Kawabata, T; Kikuchi, H; Konno, H; Ohta, M; Tanaka, T; Yamamoto, M1
Choi, SH; Chung, JW; Im, SA; Jae, HJ; Jun, S; Kim, HC; Park, JH; Yamasaki, Y1
Akiyama, S; Dat, le T; Goto, H; Hanibuchi, M; Kakiuchi, S; Kuramoto, T; Nishioka, Y; Sakaguchi, S; Sato, S; Sone, S; Van, TT; Yukishige, S1
Aogi, K; Arioka, H; Fujii, H; Fujiwara, Y; Inoue, K; Ito, Y; Iwata, H; Saeki, T; Suzuki, Y; Takatsuka, Y; Toi, M; Tokuda, Y; Watanabe, T1
Barraja, P; Beall, HD; Bunderson, M; Moody, CJ; Newsome, JJ; Swann, E; Tooke, JE; Whatmore, JL1
Ellis, LM1
Alileche, A1
Bergers, G; Bergsland, E; Hanahan, D; Meyer-Morse, N; Song, S1
Abdollahi, A; Debus, J; Hahnfeldt, P; Han, X; Hlatky, L; Howlett, AR; Huber, PE; Krempien, R; Lipson, KE; Trinh, T; Weber, KJ1
Hasselbalch, HC1
Erber, R; Groth, G; Hammes, HP; Katsen, AD; Kerger, H; Menger, MD; Thurnher, A; Ullrich, A; Vajkoczy, P1
Abrams, T; Calderan, L; Crescimanno, C; Degrassi, A; Farace, P; Giusti, A; Marzola, P; Murray, L; Nicolato, E; Osculati, F; Pesenti, E; Sbarbati, A; Terron, A1
Bruns, CJ; Guba, M; Jauch, KW; Kleespies, A1
Abbruzzese, JL; Davis, DW; Demetri, GD; Herbst, RS; Heymach, JV; McConkey, DJ; Rashid, A; Raut, CP; Shen, Y; Stadler, WM; Takamori, R; Wen, S; Xiong, HQ1
Capelle, HH; Erber, R; Farhadi, MR; Ullrich, A; Vajkoczy, P1
Elitzsch, A; Laschke, MW; Menger, MD; Vajkoczy, P; Vollmar, B1
Kitagawa, Y; Kitajima, M; Kubota, T; Nakamura, T; Ozawa, S; Ueda, M1
Fu, A; Hallahan, DE; Huamani, J; Kim, DW1
Bani, MR; Borsotti, P; Cassis, L; Eccles, SA; Garofalo, A; Giavazzi, R; Naumova, E; Riccardi, E; Scanziani, E; Ubezio, P1
Jiang, XT; Tao, HQ; Zou, SC1
Grosicka, A; Grosicki, S; Hołowiecki, J1
Abdollahi, A; Debus, J; Hauser, K; Huber, PE; Lipson, KE; Roth, A; Timke, C; Weber, KJ; Zieher, H1
Blake, RA; Fong, TA; Hawtin, R; Hirth, KP; Hubbard, SR; Laird, AD; Liang, C; McMahon, G; Mohammadi, M; Schlessinger, J; Shawver, LK; Shenoy, N; Strawn, LM; Sun, L; Tang, C; Tang, F; Thurnher, A; Ullrich, A; Vajkoczy, P1
Bucana, CD; Davis, DW; Drazan, KE; Ellis, LM; Liu, W; McConkey, DJ; McMahon, G; Ogura, Y; Reinmuth, N; Shaheen, RM; Tseng, WW; Vellagas, R; Wieczorek, AA1
Bucana, CD; Ellis, LM; Gallick, GE; Jung, YD; McConkey, DJ; McMahon, G; Solorzano, CC1

Reviews

3 review(s) available for orantinib and Angiogenesis, Pathologic

ArticleYear
A targeted approach for antiangiogenic therapy of metastatic human colon cancer.
    The American surgeon, 2003, Volume: 69, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Colonic Neoplasms; Colorectal Neoplasms; Endothelial Growth Factors; Extracellular Matrix; Humans; Indoles; Integrins; Intercellular Signaling Peptides and Proteins; Lymphokines; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Vascular endothelial growth factor in esophageal cancer.
    Journal of surgical oncology, 2004, Aug-01, Volume: 87, Issue:2

    Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Barrett Esophagus; Bevacizumab; Carcinoma, Squamous Cell; Esophageal Neoplasms; Humans; Indoles; Lymphangiogenesis; Neovascularization, Pathologic; Oxindoles; Prognosis; Propionates; Protein-Tyrosine Kinases; Pyrroles; RNA, Catalytic; RNA, Messenger; Vascular Endothelial Growth Factor A

2004
[Clinical importance of angiogenesis and angiogenic factors in oncohematology].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2007, Volume: 60, Issue:1-2

    Topics: Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Angiopoietin-1; Angiopoietin-2; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Multiple Myeloma; Myelodysplastic Syndromes; Neoplasm Metastasis; Neovascularization, Pathologic; Oxindoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Propionates; Pyrroles; Receptor, TIE-2; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factors

2007

Trials

1 trial(s) available for orantinib and Angiogenesis, Pathologic

ArticleYear
A multicenter phase II study of TSU-68, a novel oral multiple tyrosine kinase inhibitor, in patients with metastatic breast cancer progressing despite prior treatment with an anthracycline-containing regimen and taxane.
    International journal of clinical oncology, 2013, Volume: 18, Issue:4

    Topics: Adult; Aged; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Bridged-Ring Compounds; Drug Administration Schedule; Female; Gene Expression Regulation, Neoplastic; Humans; Indoles; Middle Aged; Neovascularization, Pathologic; Oxindoles; Propionates; Protein Kinase Inhibitors; Pyrroles; Taxoids; Treatment Outcome; Vascular Endothelial Growth Factor A

2013

Other Studies

23 other study(ies) available for orantinib and Angiogenesis, Pathologic

ArticleYear
[Effect of Endostatin and SU6668 combined with 5-FU on human colon cancer xenograft in nude mice].
    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2008, Volume: 11, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colonic Neoplasms; Endostatins; Fluorouracil; Humans; Indoles; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles

2008
Inhibition of tyrosine kinase receptors by SU6668 promotes abnormal stromal development at the periphery of carcinomas.
    British journal of cancer, 2009, May-19, Volume: 100, Issue:10

    Topics: Animals; Carcinoma; Cell Proliferation; Colonic Neoplasms; Disease Progression; HT29 Cells; Humans; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Receptor Protein-Tyrosine Kinases; Stromal Cells; Up-Regulation; Xenograft Model Antitumor Assays

2009
TSU68, an antiangiogenic receptor tyrosine kinase inhibitor, induces tumor vascular normalization in a human cancer xenograft nude mouse model.
    Surgery today, 2009, Volume: 39, Issue:12

    Topics: Angiogenesis Inhibitors; Animals; Colon; Colonic Neoplasms; Disease Models, Animal; Drug Delivery Systems; Humans; Indoles; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxindoles; Propionates; Pyrroles; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Sensitivity and Specificity; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays

2009
Augmentation of chemotherapeutic infusion effect by TSU-68, an oral targeted antiangiogenic agent, in a rabbit VX2 liver tumor model.
    Cardiovascular and interventional radiology, 2012, Volume: 35, Issue:1

    Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Ethiodized Oil; Indoles; Infusions, Intravenous; Liver Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Rabbits; Statistics, Nonparametric; Tomography, X-Ray Computed

2012
SU6668, a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model.
    Respirology (Carlton, Vic.), 2012, Volume: 17, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Fibroblast Growth Factor 2; Humans; Indoles; Male; Mesothelioma; Mice; Mice, SCID; Neovascularization, Pathologic; Oxindoles; Pleural Effusion, Malignant; Pleural Neoplasms; Propionates; Protein Kinase Inhibitors; Pyrroles; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays

2012
Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents.
    Angiogenesis, 2002, Volume: 5, Issue:1-2

    Topics: Angiogenesis Inhibitors; Endothelium, Vascular; Humans; Indoles; Isoflavones; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Quinoxalines

2002
Interleukin-2 and cancer: critical analysis of results, problems and expectations.
    Medical hypotheses, 2003, Volume: 60, Issue:2

    Topics: Cytokines; Humans; Immunotherapy; Indoles; Interleukin-2; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptors, Interleukin-2

2003
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.
    The Journal of clinical investigation, 2003, Volume: 111, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Vessels; Carcinoma, Islet Cell; Endothelium, Vascular; Female; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor

2003
SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.
    Cancer research, 2003, Jul-01, Volume: 63, Issue:13

    Topics: Angiogenesis Inhibitors; Cell Division; Cells, Cultured; Dose-Response Relationship, Radiation; Endothelial Growth Factors; Endothelium, Vascular; Fibroblast Growth Factor 2; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Kinetics; Lymphokines; Male; Neoplasm Invasiveness; Neovascularization, Pathologic; Oxindoles; Particle Accelerators; Propionates; Prostatic Neoplasms; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; X-Rays

2003
SU6668 in idiopathic myelofibrosis--a rational therapeutic approach targeting several tyrosine kinases of importance for the myeloproliferation and the development of bone marrow fibrosis and angiogenesis.
    Medical hypotheses, 2003, Volume: 61, Issue:2

    Topics: Bone Marrow; Enzyme Inhibitors; Humans; Indoles; Models, Biological; Neovascularization, Pathologic; Oxindoles; Primary Myelofibrosis; Propionates; Pyrroles; Receptor Protein-Tyrosine Kinases

2003
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:2

    Topics: Animals; Apoptosis; Cell Survival; Hypoxia; Indoles; Microcirculation; Models, Biological; Neoplasms; Neovascularization, Pathologic; Oxindoles; Pericytes; Platelet-Derived Growth Factor; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2004
In vivo assessment of antiangiogenic activity of SU6668 in an experimental colon carcinoma model.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Jan-15, Volume: 10, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Colonic Neoplasms; Contrast Media; Humans; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Models, Statistical; Neoplasm Transplantation; Neovascularization, Pathologic; Oxindoles; Permeability; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Protein-Tyrosine Kinases; Pyrroles; Time Factors

2004
Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Jan-15, Volume: 11, Issue:2 Pt 1

    Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Indoles; Male; Mice; Mice, Nude; Middle Aged; Neovascularization, Pathologic; Oxindoles; Pancreatic Neoplasms; Phosphorylation; Propionates; Pyrroles; Receptor, Platelet-Derived Growth Factor beta; Transplantation, Heterologous; Vascular Endothelial Growth Factor Receptor-2

2005
Combined inhibition of vascular endothelial growth factor and platelet-derived growth factor signaling: effects on the angiogenesis, microcirculation, and growth of orthotopic malignant gliomas.
    Journal of neurosurgery, 2005, Volume: 102, Issue:2

    Topics: Animals; Apoptosis; Brain; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Transformation, Neoplastic; Glioma; Indoles; Mice; Mice, Nude; Microcirculation; Microscopy, Fluorescence; Microscopy, Video; Neoplasm Transplantation; Neovascularization, Pathologic; Oxindoles; Platelet-Derived Growth Factor; Propionates; Protein-Tyrosine Kinases; Pyrroles; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Transplantation, Heterologous; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2005
Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions.
    Human reproduction (Oxford, England), 2006, Volume: 21, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Capillaries; Cricetinae; Endometriosis; Endometrium; Female; Fibroblast Growth Factors; Indoles; Mesocricetus; Neovascularization, Pathologic; Oxindoles; Platelet-Derived Growth Factor; Propionates; Protein Kinase Inhibitors; Pyrroles; Uterine Diseases; Vascular Endothelial Growth Factor A

2006
Antiangiogenic agent SU6668 suppresses the tumor growth of xenografted A-431 cells.
    Oncology reports, 2006, Volume: 15, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Carcinoma, Squamous Cell; Endothelium, Vascular; Esophageal Neoplasms; Humans; Indoles; Mice; Mice, SCID; Neoplasm Transplantation; Neovascularization, Pathologic; Oxindoles; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Pyrroles; Xenograft Model Antitumor Assays

2006
Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy.
    International journal of radiation oncology, biology, physics, 2006, Jan-01, Volume: 64, Issue:1

    Topics: Angiogenesis Inhibitors; Animals; Class I Phosphatidylinositol 3-Kinases; Combined Modality Therapy; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Indoles; Mice; Neoplasms; Neovascularization, Pathologic; Oxindoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Propionates; Pyrroles; Quinazolines; Radiation Tolerance; Receptor Protein-Tyrosine Kinases; Sunitinib; Vascular Endothelial Growth Factor A

2006
The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Mar-15, Volume: 12, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line; Cell Line, Tumor; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Endothelial Cells; Female; Immunohistochemistry; Indoles; Laminin; Mice; Mice, Nude; Myocytes, Smooth Muscle; Neovascularization, Pathologic; Neovascularization, Physiologic; Oxindoles; Paclitaxel; Platelet Endothelial Cell Adhesion Molecule-1; Propionates; Protein-Tyrosine Kinases; Proteoglycans; Pyrroles; Xenograft Model Antitumor Assays

2006
[Effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice].
    Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery, 2006, Volume: 9, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Drug Synergism; Fluorouracil; Humans; Indoles; Liver Neoplasms; Male; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Stomach Neoplasms

2006
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Apr-01, Volume: 14, Issue:7

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Endothelial Cells; Flow Cytometry; Humans; Immunohistochemistry; Indoles; Mice; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Oxindoles; Propionates; Protein Kinase Inhibitors; Pyrroles; Radiation-Sensitizing Agents; Radiotherapy; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays

2008
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.
    Cancer research, 2000, Aug-01, Volume: 60, Issue:15

    Topics: 3T3 Cells; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Division; Crystallography, X-Ray; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Indoles; Kinetics; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Neoplasms, Experimental; Neovascularization, Pathologic; Oxindoles; Propionates; Protein-Tyrosine Kinases; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptor, Platelet-Derived Growth Factor beta; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Receptors, Mitogen; Receptors, Vascular Endothelial Growth Factor; Transplantation, Heterologous; Tumor Cells, Cultured

2000
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms.
    Cancer research, 2001, Feb-15, Volume: 61, Issue:4

    Topics: Angiogenesis Inhibitors; Animals; Apoptosis; Cell Division; Cell Survival; Colonic Neoplasms; Endothelium, Vascular; Indoles; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Oxindoles; Propionates; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor

2001
In vivo intracellular signaling as a marker of antiangiogenic activity.
    Cancer research, 2001, Oct-01, Volume: 61, Issue:19

    Topics: Androstadienes; Angiogenesis Inhibitors; Biomarkers, Tumor; Blotting, Western; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Fluorescent Antibody Technique; Humans; Indoles; Liver Neoplasms; Lymphokines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neovascularization, Pathologic; Oxindoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrroles; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

2001