orabase and Ulcer

The development of ideal wound dressing materials with excellent characteristics is currently a major demand in wound therapy. In recent years, carboxymethyl cellulose (CMC)-based wound dressing materials have been of immense attraction due to their noble properties, such as: biocompatibility, biodegradability, tissue resembling, low cost and non-toxic. It is used extensively, in a variety of applications in the biomedical and pharmaceutical fields. The hydrophilic nature of CMC, makes it possible to blend and cross-link with other materials, such as: synthetic polymers, natural polymers and inorganic materials and it enables the preparation of innovative wound dressing biomaterials. Hence, this review, focuses on the intrinsic characteristics of CMC-based wound dressing materials, including hydrogels, films, 3D printing, fibres, gauzes and their recent advancements in chronic wound healing.

Topics: Animals; Bandages; Biocompatible Materials; Carboxymethylcellulose Sodium; Cellulose; Humans; Hydrogels; Infection Control; Mice; Nanoparticles; Polymers; Printing, Three-Dimensional; Ulcer; Wound Healing

To identify the prevalence of corneal ulceration in dogs receiving prophylactic gel lubrication under general anesthesia (GA).. An ophthalmic examination was performed before premedication and 24 h after GA in 100 dogs (199 eyes) undergoing nonophthalmic procedures. Individuals with known pre-existing ocular surface conditions were excluded. An ocular lubricating gel containing carmellose sodium was applied by the anesthetist at induction and every 2-4 h until extubation. Logistic regression analysis was used to calculate risk factors for ulcerative disease, including signalment, length of GA, patient position, procedure performed, pre-, and post-GA ophthalmic examination findings and admitting service. A Wilcoxon rank sum test compared pre- and post-GA Schirmer tear test-1 (STT-1) values.. One dog (0.5% of total eyes) developed fluorescein stain uptake consistent with superficial corneal ulceration that resolved within 48 h with supportive treatment. Twenty-five (18.6% of total eyes) developed a faint, patchy corneal uptake of stain in the axial cornea that was consistent with epithelial erosion. All erosions resolved with lubrication 24 h later. The decrease in STT-1 readings at 24 h post-GA was statistically significant from those pre-GA (P < 0.001). No significant risk factors for corneal erosion/ulceration were identified.. The results of this study show that a basic protocol of prophylactic lubrication during GA was associated with a low prevalence of corneal ulceration but a higher prevalence of epithelial erosion. In addition, the study supports the need for post-GA corneal examination.

Topics: Anesthesia, General; Animals; Carboxymethylcellulose Sodium; Corneal Diseases; Dog Diseases; Dogs; Lubricant Eye Drops; Postoperative Complications; Prevalence; Prospective Studies; Risk Factors; Ulcer

Topics: Arthroplasty; Biological Dressings; Carboxymethylcellulose Sodium; Humans; Ulcer; Wound Healing; Wounds and Injuries

To report the presence of an asymptomatic cilium in the subconjunctival area and an adjacent sterile scleral ulcer, together as a complication of subtenon injection of steroids, and the resolution of the ulcer despite the in situ cilium.. Medical management of a 51-year-old man, who was a known case of ankylosing spondylitis, with a 3-mm scleral ulcer located in the inferior palpebral area with one adjacent fully embedded cilium at the probable site of subtenon injection given for suspected acute iridocyclitis.. On altering the medication, the ulcer resolved completely. This occurred despite the in situ cilium, which did not act as a nidus for infection or inflammation.. The presence of cilia did not adversely affect the outcome of treatment of the adjacent ulcer. Therefore, if there is no exposure of the entrapped cilium through the conjunctiva, as was in this case, conservative management of the ulcer and not trying to remove the cilium seems to be a good alternative as opposed to reports in literature, which warrant its removal in most cases.

Topics: Anti-Bacterial Agents; Ascorbic Acid; Carboxymethylcellulose Sodium; Chloramphenicol; Cilia; Conjunctival Diseases; Drug Therapy, Combination; Eye Foreign Bodies; Humans; Iatrogenic Disease; Injections, Intraocular; Iridocyclitis; Male; Middle Aged; Scleral Diseases; Spondylitis, Ankylosing; Steroids; Tetracycline; Ulcer; Vitamins

At present no information is available about biological effects on oral tissues of the photocuring periodontal dressing Barricaid. This animal study examines histologically the tissue responses of surgical areas covered during 7 days with either Barricaid, the eugenol-containing dressing Ward's Wondrpak or the bionert control gel Carboxyl Methyl Cellulose. One group was studied immediately after the removal of the dressings; in the other group, further healing was permitted for another week. Results after 7 days indicate acute inflammatory reactions in the test areas without significant differences between the 2 periodontal dressing materials. The control areas showed to a lesser degree basically the same tissue response. In the 2nd week, generally all areas healed. After 14 days, no differences between test- and control sites could be detected. From a biological point of view, these findings suggest no contra-indication for application of this photocuring dressing material after periodontal surgery.

Topics: Animals; Carboxymethylcellulose Sodium; Dogs; Edema; Epithelium; Eugenol; Evaluation Studies as Topic; Hyperemia; Lymphocytes; Neutrophils; Periodontal Dressings; Periodontium; Plasma Cells; Resins, Synthetic; Time Factors; Ulcer; Wound Healing

Topics: Carboxymethylcellulose Sodium; Humans; Mouth; Oral Ulcer; Triamcinolone; Ulcer