orabase has been researched along with Stomatitis--Aphthous* in 14 studies
7 trial(s) available for orabase and Stomatitis--Aphthous
Article | Year |
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Lactic acid 5% mouth wash vs Kenalog in Orabase 0.1% for treatment and prophylaxis of recurrent aphthous ulcer.
The outcomes of most therapeutic modalities for recurrent aphthous ulcer (RAU) are still unsatisfactory.. To evaluate lactic acid 5% mouth wash vs Kenalog in Orabase for treatment and prophylaxis of RAU.. Forty cases with early-onset idiopathic RAU were enrolled in this study. Patients were divided into two equal groups; group A patients had used Kenalog in Orabase twice daily, and group B patients had used lactic acid 5% mouth wash 3 times daily. All patients had used the therapy for 1-2 weeks according to patients' clinical response that was evaluated according to oral clinical manifestations index (OCMI); before therapy, during course of treatments and in follow-up visits.. At the ends of both first and second weeks, from beginning of therapy, OCMI was reduced more in group B patients than in group A with statistically significant results. These results revealed that group B achieved more reduction in the size, pain, and healing time of RAU. During the follow-up period, group A showed 40% recurrence rate while group B showed 5% only.. Lactic acid 5% mouth wash is natural, safe, and effective so it is better alternative to corticosteroids for treatment and prophylaxis of RAU without any side effects. Topics: Adult; Carboxymethylcellulose Sodium; Drug Administration Schedule; Drug Combinations; Female; Follow-Up Studies; Humans; Lactic Acid; Male; Middle Aged; Mouthwashes; Recurrence; Severity of Illness Index; Stomatitis, Aphthous; Treatment Outcome; Triamcinolone Acetonide; Young Adult | 2020 |
Dexamucobase: a novel treatment for oral aphthous ulceration.
Recurrent oral aphthous ulceration is a common condition treated with topical anti-inflammatory drugs, such as triamcinolone acetonide in Orabase (Kenalog in Orabase, Bristol-Myers Squibb). The aim of the study was to synthesize a novel dental paste containing dexamethasone and assess the therapeutic effect of this paste in comparison with a commonly used treatment, triamcinolone acetonide in Orabase, in oral aphthous ulceration.. The design was a case-control study. The setting was the laboratory of postgraduate students in the College of Pharmacy, University of Mosul, Iraq. Clinical evaluation of the paste was conducted in the outpatient clinic of the Oral Medicine Department, College of Dentistry, University of Baghdad, Iraq. The novel paste (named dexamucobase) was prepared under aseptic conditions and evaluated for its therapeutic effect in 53 patients with recurrent aphthous stomatitis, in comparison with 37 patients treated with triamcinolone acetonide in Orabase.. Healing of the ulcer was significantly faster (P < .001), and adverse effects were significantly reduced (P < .01) for the dexamucobase treatment compared to Kenalog in Orabase. There was no significant difference in the speed of pain reduction between the dexamucobase treatment compared to Kenalog in Orabase.. The novel dexamucobase was found to be equally effective in treating oral aphthous ulceration, with some advantages, as the widely used preparation Kenalog in Orabase. Topics: Adolescent; Adult; Anti-Inflammatory Agents; Carboxymethylcellulose Sodium; Dexamethasone; Female; Humans; Male; Middle Aged; Ointments; Stomatitis, Aphthous; Treatment Outcome; Triamcinolone Acetonide; Young Adult | 2009 |
The treatment of oral aphthous ulceration or erosive lichen planus with topical clobetasol propionate in three preparations: a clinical and pilot study on 54 patients.
This study evaluated the clinical use of a corticosteroid in three preparations (topical clobetasol propionate ointment, clobetasol propionate in an oral analgesic base, and clobetasol propionate in an adhesive denture paste).. Fifty-four patients (34 males and 20 females) with a history of vesiculo-ulcero-erosive oral lesions were selected: 24 with oral erosive lichen planus and 30 with aphthae. The subjects enrolled were randomly divided into three groups, each of 18 patients (10 with aphthae and 8 with lichen planus): the first was treated with topical clobetasol propionate ointment (0.05%) directly on the lesion(s) three times a day; the second with clobetasol propionate in an adhesive denture paste in equal amounts (1:1) two times a day; the third with clobetasol propionate in an oral analgesic base (Orabase-B) in equal amounts (1:1) two times a day. Each subject scored his or her symptoms daily from most severe (7) to none (0) by verbal assessments using a categorical scale.. In all cases, the administration of the corticosteroid was effective in producing remission of symptoms in each group of patients. Significant differences (P<0.05) between groups were determined by the Kruskal-Wallis test. The Dunn test was used in order to detect which group differs from the others; clobetasol and adhesive denture paste correlated with an early remission of pain in lichen and apthous lesions.. The results suggest that topical application of clobetasol in an adhesive denture paste is an effective drug for symptomatic oral vesiculo-erosive and/or ulcerative lesions. Topics: Adhesives; Administration, Topical; Adolescent; Adult; Anesthetics, Local; Anti-Inflammatory Agents; Benzocaine; Carboxymethylcellulose Sodium; Clobetasol; Female; Glucocorticoids; Humans; Lichen Planus, Oral; Male; Middle Aged; Ointments; Pilot Projects; Stomatitis, Aphthous | 2001 |
Evaluating the efficacy of 2-octyl cyanoacrylate bioadhesive for treatment of oral ulcerations.
Studies were recently completed that evaluated a novel bioadhesive device for use in treating oral ulcerations. This article reviews the research protocols and results of these studies on the bioadhesive's safety, ability to decrease immediate and long-term pain, effects on ulcer healing, and equivalence to a predicate device in providing pain relief for oral ulcers. Topics: Analgesics; Carboxymethylcellulose Sodium; Cyanoacrylates; Device Approval; Humans; Nonprescription Drugs; Pain Measurement; Protective Agents; Single-Blind Method; Stomatitis, Aphthous; Tissue Adhesives; United States; United States Food and Drug Administration | 2001 |
Clinical treatment evaluations of a new topical oral medication.
Clinical symptoms of viral infections, such as herpes labialis (cold sores) and oral ulcers (canker sores), are common in adulthood, affecting approximately 19% of adults aged 25 to 44 years. For some patients, lesions last longer, are more painful, and are more difficult to treat, requiring medications that allow the affected area to heal but do little to alleviate pain. Conventionally, pain caused by oral ulcerations has been addressed with either topical analgesics or systemic pain medications. However, a recently introduced over-the-counter topical medication (ORABASE Soothe.N.Seal) has been shown to be an effective pain-relieving adjunct to healing therapies. This article reviews the characteristics of painful oral ulcerations and details the research findings of a clinical trial of the use of this new medication. Topics: Adult; Carboxymethylcellulose Sodium; Cyanoacrylates; Humans; Oral Ulcer; Patient Satisfaction; Protective Agents; Stomatitis, Aphthous; Stomatitis, Herpetic; Surveys and Questionnaires; Tissue Adhesives | 2001 |
An evaluation of a chemical cautery agent and an anti-inflammatory ointment for the treatment of recurrent aphthous stomatitis: a pilot study.
Recurrent aphthous stomatitis is a very common condition, currently treated with anti-inflammatory agents, which palliate the symptoms. The purpose of this clinical trial was to compare a medication commonly used to treat recurrent aphthous stomatitis, Kenalog-in-Orabase, and a newer agent, Debacterol.. Sixty patients diagnosed with recurrent aphthous stomatitis were enrolled in the study. Twenty patients were assigned to each of the two treatment groups, and 20 age- and sex-matched patients were assigned to the control group, which received no treatment. After the diagnosis was made, clinical examinations and ulcer measurements were performed, and a subjective evaluation of symptoms (100-mm visual analog scale) was completed by each subject. The subjects did not use any other medications. Both agents were applied topically (the frequency varied depending on the group of subjects) at specified intervals. Ulcer measurements and subjective evaluations were made at days 0, 3, 6, and 10 for all subjects.. In both treatment groups, by day 10, 100% of the ulcers had clinically healed and were no longer causing pain. Patients in the Debacterol group reported a significantly greater decrease in pain at 3 days (> 70%) than did subjects in the other groups (< 20%), although the size of the ulcer did not differ significantly in any of the groups. After day 6, 80% of the ulcers in the Debacterol group had clinically disappeared and no longer caused symptoms, as compared to about 30% in the other groups.. Patients subjectively reported significantly greater relief from symptoms with Debacterol than with Kenalog-in-Orabase or no treatment. The relief of symptoms associated with recurrent aphthous stomatitis may or may not correspond to clinical improvement, and these two topical medications may affect signs and symptoms of the lesions differently. Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Carboxymethylcellulose Sodium; Caustics; Drug Combinations; Female; Glucocorticoids; Humans; Male; Pain Measurement; Phenols; Pilot Projects; Recurrence; Stomatitis, Aphthous; Sulfuric Acids; Triamcinolone Acetonide | 1998 |
Performance of a hydroxypropyl cellulose film former in normal and ulcerated oral mucosa.
Although oral ulcers are commonly encountered in clinical dental and medical practice, current therapeutic options with respect to pain relief are limited. This study evaluated the mucosal binding characteristics and the pain relief and protection properties of Zilactin, a hydroxypropyl cellulose film former. In 12 healthy volunteers, the mean duration of mucosal adherence of Zilactin was 3.92 hours, which was significantly longer than that of a widely available topical preparation (1.38 hours, p = 0.0001). When evaluated in 20 subjects with recurrent aphthous ulcerations, Zilactin demonstrated the ability to significantly decrease ulcer pain over a 4-hour period when compared with the subjects' individual standardized level of initial discomfort, which was used as an internal control for all subsequent steps. Challenge with an irritating citrus beverage was made before and after application of the medication. A significant difference in premedication and postmedication sensitivity was shown (p = 0.0001), indicating that the film provides protection, as well as pain relief. As a result of its unique and tenacious film-forming characteristics, this agent is exceptionally effective in the treatment of oral mucosal ulcerations. Greater awareness on the part of physicians and dentists may lead to the development of additional applications. Topics: Adhesiveness; Administration, Topical; Adult; Carboxymethylcellulose Sodium; Cellulose; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Mouth Mucosa; Pain; Recurrence; Stomatitis, Aphthous; Time Factors | 1988 |
7 other study(ies) available for orabase and Stomatitis--Aphthous
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Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges
Recurrent aphthous ulcer (RAU) is a well-known painful, inflammatory disease with uncertain etiology for which local symptomatic therapy is only available. The aim of this study was to formulate and characterize muco-adhesive sponges containing a mixture of tenoxicam and miconazole nitrate to manage pain, inflammation and avoid candida infection that may accompany RAU due to poor oral hygiene. Two polymers at different concentrations were used to prepare sponges applying simple freeze-drying. Medicated chitosan (2%) sponges (mC2) showed acceptable physical appearance, surface pH (6.3 ± 0.042), porosity (25.7% ± 1.8), swelling index (5.7 ± 0.11), Topics: Adhesives; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Carboxymethylcellulose Sodium; Chitosan; Dose-Response Relationship, Drug; Drug Carriers; Drug Liberation; Freeze Drying; Hydrogen-Ion Concentration; Miconazole; Microscopy, Electron, Scanning; Piroxicam; Rats; Stomatitis, Aphthous; Wound Healing | 2021 |
On call: I am a 71-year-old man with diabetes and high blood pressure. Ever since I can remember, I've been bothered by painful canker sores two or three times a year. My doctor says they aren't caused by my medication and I think he's right, since the ca
Topics: Aged; Anesthetics, Local; Carboxymethylcellulose Sodium; Diphenhydramine; Drug Combinations; Humans; Lidocaine; Magnesium Oxide; Male; Stomatitis, Aphthous | 2004 |
Recurrent oral ulceration.
Topics: Administration, Topical; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Carboxymethylcellulose Sodium; Fluocinolone Acetonide; Glucocorticoids; Humans; Secondary Prevention; Stomatitis, Aphthous | 2003 |
Recurrent oral ulcers--an overview.
Recurrent oral ulcers (ROUs) are the most common oral mucosal disease. The etiology of ROUs is complex. The factors include mechanical trauma, genetics, stress, smoking, and viral and bacterial infections. Treatment modalities depend on the differential diagnosis of ROUs and could consist of antimicrobial agents, anti-inflammatory agents, immunomodulators, or over-the-counter medications. New therapy available in the form of a coating polymer, Colgate ORABASE Soothe.N.Seal, is clinically proven to provide rapid relief and healing of ROUs. Topics: Carboxymethylcellulose Sodium; Humans; Protective Agents; Stomatitis, Aphthous; Tissue Adhesives | 2001 |
Cyanoacrylate medical adhesives--a new era Colgate ORABASE Soothe.N.Seal Liquid Protectant for canker sore relief.
Cyanoacrylate, a synthetic adhesive, is a fast polymerizable liquid monomer. Serendipity led to the discovery of cyanoacrylate adhesives in 1951. Today, a specific cyanoacrylate monomer, 2-octyl cyanoacrylate, is being used in a topical medical adhesive formulation. The only over-the-counter cyanoacrylate-based product cleared by the Food and Drug Administration is Colgate ORABASE Soothe.N. Seal Liquid Protectant. Upon application, this liquid monomer formulation polymerizes instantly into a thin, flexible polymer film that adheres tenaciously to mucosal tissue. This polymer film creates a mechanical barrier that provides immediate and long-term pain relief of oral ulcerations and irritations, and maintains a natural healing environment for the area to heal. Topics: Analgesics; Carboxymethylcellulose Sodium; Cyanoacrylates; Dermatologic Agents; Humans; Lacerations; Protective Agents; Stomatitis, Aphthous; Tissue Adhesives | 2001 |
Treating recurrent aphthous ulcers in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Carboxymethylcellulose Sodium; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Humans; Leukocyte Count; Male; Mouth Mucosa; Prednisone; Recurrence; Stomatitis, Aphthous; Triamcinolone | 1991 |
Major aphthous-like ulcers in patients with AIDS.
This report describes persistent, painful oral ulcers that occurred in nine patients with the acquired immunodeficiency syndrome (AIDS). These ulcers resembled major aphthous ulcers in clinical appearance and response to therapy. They occurred less frequently in patients with AIDS than those caused by herpes simplex and were found in 4 of 346 (1.1%) patients with AIDS at one medical center. Lesions were typically painful. Identification and treatment with topical tetracycline and steroids led to resolution with relief of symptoms. Further study is necessary to understand the etiology and pathogenesis of these ulcers. Topics: Acquired Immunodeficiency Syndrome; Carboxymethylcellulose Sodium; Female; Humans; Male; Stomatitis, Aphthous; Tetracycline; Triamcinolone Acetonide | 1991 |