orabase and Staphylococcal-Infections

The poor bioadhesion capacity of tilmicosin resulting in treatment failure for. This study aimed to increase the bioadhesion capacity of tilmicosin for the SASCVs strain and improve the antibacterial effect of tilmicosin against cow mastitis caused by the SASCVs strain.. Tilmicosin-loaded chitosan oligosaccharide (COS)-sodium carboxymethyl cellulose (CMC) composite nanogels were formulated by an electrostatic interaction between COS (positive charge) and CMC (negative charge) using sodium tripolyphosphate (TPP) (ionic crosslinkers). The formation mechanism, structural characteristics, bioadhesion, and antibacterial activity of tilmicosin composite nanogels were studied systematically.. The optimized formulation was comprised of 50 mg/mL (COS), 32 mg/mL (CMC), and 0.25 mg/mL (TPP). The size, encapsulation efficiency, loading capacity, polydispersity index, and zeta potential of the optimized tilmicosin composite nanogels were 357.4 ± 2.6 nm, 65.4 ± 0.4%, 21.9 ± 0.4%, 0.11 ± 0.01, and -37.1 ± 0.4 mV, respectively; the sedimentation rate was one. Scanning electron microscopy showed that tilmicosin might be incorporated in nano-sized crosslinked polymeric networks. Moreover, adhesive studies suggested that tilmicosin composite nanogels could enhance the bioadhesion capacity of tilmicosin for the SASCVs strain. The inhibition zone of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels were 2.13 ± 0.07, 3.35 ± 0.11, and 1.46 ± 0.04 cm, respectively. The minimum inhibitory concentration of native tilmicosin, tilmicosin standard, and tilmicosin composite nanogels against the SASCVs strain were 2, 1, and 1 µg/mL, respectively. The. This study provides a potential strategy for developing tilmicosin composite nanogels to treat cow mastitis caused by the SASCVs strain.

Topics: Animals; Anti-Bacterial Agents; Carboxymethylcellulose Sodium; Cattle; Chitosan; Female; Mastitis, Bovine; Nanogels; Oligosaccharides; Staphylococcal Infections; Staphylococcus aureus; Tylosin

Nonwoven fabrics containing silver nanoparticles (AgNPs) are widely utilized to assist management of infected wounds and those at risk of infection. However, such materials have varied responses due to their chemical nature. Herein we investigated the correlation between the concentration of AgNPs taken up by nonwoven viscose material and antibacterial activity in a simulated wound fluid model against two bacterial models (i.e., Escherichia coli and Staphylococcus aureus). Thereafter, the developed nonwoven viscose containing AgNPs were independently coated with two polyacid carbohydrate polymers (i.e., carboxymethyl chitosan (CMCs), alginate (ALG)), and gelatin (GEL) protein in order to study their influence on the physical and biological attributes in vitro and in vivo. Intensive characterizations were utilized to monitor the physicochemical features of the developed nonwoven viscose. The results demonstrated that higher concentrations of AgNPs were taken up by viscose fabric whilewhile increasing AgNPs in the colloidal solution during padding process. Overall, the treated nonwoven fabric with and without polymers' coatings showed remarkable antibacterial activity against two bacterial models in vitro. As well as they achieved high and speed wound recovery in rats which was almost similar to commercial dermazin treatment. Therefore, it validates excellent nonwoven dressing clinically relevant to the wound type and condition.

Topics: Alginates; Animals; Anti-Bacterial Agents; Bandages; Burns, Chemical; Carboxymethylcellulose Sodium; Chitosan; Delayed-Action Preparations; Escherichia coli; Escherichia coli Infections; Gelatin; Metal Nanoparticles; Rats; Silver; Skin; Staphylococcal Infections; Staphylococcus aureus; Wound Healing

In hernia surgery, soaking of meshes in antibiotics before implantation is a prophylactic strategy for minimizing the risk of infection while providing minimal, local, drug doses. This study describes the development and application of an antibacterial mesh coating comprising a carboxymethylcellulose gel loaded with rifampicin in a preclinical model of Staphylococcus aureus and S. epidermidis infection in rabbits.. In vitro, rifampicin-carboxymethylcellulose gel demonstrated great activity against Staphylococcus aureus/S. epidermidis, while being innocuous for fibroblasts. In vivo, rifampicin-carboxymethylcellulose gel-coated implants displayed full bacterial clearance and optimal tissue integration, irrespective of the strain of Staphylococcus. In contrast, uncoated and carboxymethylcellulose gel-coated implants exhibited macro/microscopic signs of infection and impaired tissue integration. Macrophage responses were less in rifampicin-carboxymethylcellulose gel implants than in uncoated mesh (Staphylococcus aureus/S. epidermidis; P < .01) and carboxymethylcellulose gel (S. epidermidis; P < .05) implants. Bloodstream levels of rifampicin were undetectable.. Soaking meshes in rifampicin-carboxymethylcellulose gel inhibited effectively the bacterial adhesion to the mesh without compromising the tissue repair. This antibiotic gel constitutes an easy-to-use and effective prophylactic strategy that potentially reduce the prevalence of postoperative mesh infection.

Topics: Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Carboxymethylcellulose Sodium; Disease Models, Animal; Hernia, Abdominal; Herniorrhaphy; Humans; Male; Microbial Sensitivity Tests; Rabbits; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Surgical Mesh; Surgical Wound Infection

Biomaterials with an antimicrobial coating could avoid mesh-associated infection following hernia repair. This study assesses the use of a chlorhexidine-loaded carboxymethylcellulose gel in a model of Staphylococcus aureus mesh infection.. Carboxymethylcellulose significantly reduced the toxicity of chlorhexidine (p < 0.001) without limiting its antibacterial activity. While control and gel-coated implants were intensely contaminated, the chlorhexidine-gel-coated meshes showed a bacteria-free surface, and only one specimen showed infection signs. The macrophage reaction in this last group was reduced compared to the control (p < 0.05) and gel groups.. When incorporated in the carboxymethylcellulose gel, chlorhexidine showed reduced toxicity yet maintained its bactericidal effect at the surgery site. Our findings suggest that this antibacterial gel-coated polypropylene meshes for hernia repair prevent bacterial adhesion to the mesh surface and have no detrimental effects on wound repair.

Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Adhesion; Biocompatible Materials; Carboxymethylcellulose Sodium; Chlorhexidine; Fibroblasts; Gels; Herniorrhaphy; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Surgical Mesh

A formulation of an antibody with antibacterial properties for topical use on Staphylococcal skin infections was developed and characterized. The best formulation was obtained with 1.5% (w/v) sodium carboxymethylcellulose containing 10 mg/ml immunoglobulin. Spraying forces and rheological behavior were measured in order to characterize the hydrogel formulation. The percentage of antibody aggregates in gel as well as the antibody release, folding and target binding properties of the released antibody were analyzed to proof an acceptable shelf life and no significant changes in the activity of the antibody over time. No microbial contamination was observed in the chosen non-airless application container. Functional testing of the topical skin formulation was performed with an ex vivo biopsy culture model of dog skin. Histological analysis indicated efficacy in protection from Staphylococcus mediated skin damage and antibody delivery restricted to the epidermal surface. The results demonstrate that this hydrogel is suitable for cutaneous antibody applications in the medical field.

Topics: Administration, Cutaneous; Animals; Anti-Bacterial Agents; Antibodies; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Dogs; Drug Liberation; Hydrogels; Immunoglobulins; Rheology; Skin; Skin Absorption; Staphylococcal Infections; Staphylococcus

To investigate the therapeutic effectiveness of ion-activated mucoadhesive hydrogel system in the treatment of experimental bacterial keratitis.. Mucoadhesive systems were prepared using gellan or sodium alginate alone and combined with sodium carboxymethylcellulose (NaCMC) to enhance the gel bioadhesion properties. The in vivo antimicrobial efficacy of selected mucoadhesive systems was studied in an experiment on bacterial keratitis in rabbit's eyes and compared with that of the marketed conventional eyedrops.. Ocular tolerance was studied in the eye of albino rabbits and tested formulations were non-irritant with no sign of inflammation. Better improvement in experimental bacterial keratitis in rabbit eyes was observed in animals treated with mucoadhesive hydrogel formulation (GG5 and GS5) compared with marketed drug solution.. The developed system is a viable alternative to conventional eyedrops of GTN due to its ability to enhance bioavailability through its longer precorneal residence time.

Topics: Alginates; Animals; Anti-Bacterial Agents; Biological Availability; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Corneal Ulcer; Disease Models, Animal; Drug Carriers; Eye Infections, Bacterial; Fluoroquinolones; Gatifloxacin; Glucuronic Acid; Hexuronic Acids; Hydrogels; Polysaccharides, Bacterial; Rabbits; Staphylococcal Infections; Staphylococcus aureus; Treatment Outcome

This article reports on comparative in vitro characterization and in vivo evaluation of pre-formed cellulose-based gels, methylcellulose (MC) and carboxymethylcellulose sodium (CMC) and in situ gel-forming Pluronic F127 (PL) for ocular delivery of ciprofloxacin hydrochloride (Cipro) by using a bacterial keratitis model and histological corneal examination. Drug-polymer interactions were studied employing thermal analysis. Further, different concentrations (1-3% w/w or 10-30% w/w) of gels depending on the nature of the polymer used were prepared, characterized for clarity, pH, rheology and in vitro release. Selected gel formulations were evaluated for ocular delivery to Staphylococcus aureus-infected rabbit corneas; and ocular toxicity through histological examination of the cornea. The results demonstrated no Cipro-polymers physicochemical interactions and pseudoplastic flow for all gels used at 35 °C. Both polymer concentrations and drug solubility in the gels are dominantly the rate-determining factors for in vitro drug release. The corneal healing rate for all gel-based formulations was significantly faster (p < 0.05) than that for Cipro solution-treated rabbits. PL-based gel induced significant swelling/edema of the corneal stroma, compared with MC- and CMC-based gels. In conclusion, cellulose-based polymers have superior ocular tolerability/dramatically less irritant; and superior efficacy with more convenient administration compared with PL and Cipro solution, respectively.

Topics: Animals; Anti-Bacterial Agents; Carboxymethylcellulose Sodium; Ciprofloxacin; Cornea; Delayed-Action Preparations; Female; Gels; Keratitis; Male; Methylcellulose; Poloxamer; Rabbits; Rheology; Staphylococcal Infections; Staphylococcus aureus; Viscosity

Silver-containing dressings are commonly used on healing wounds, including diabetic ulcers. Some studies have shown that dressing materials with silver have negative effects on wound healing, specifically, that the wound healing process is inhibited by deposited silver. Therefore, the authors treated wounds infected with methicillin-resistant Staphylococcus aureus (MRSA) in Sprague-Dawley (SD) rats and streptozotocin (STZ)-induced diabetic rats with silver dressings to evaluate the risks of silver.. The study used 54 SD rats and 54 STZ-induced diabetic rats. Full-thickness skin defects were created in all animals and then infected with MRSA. The rats were divided into 6 groups according to the dressing materials: nanocrystalline silver (Ac) (ACTICOAT, Smith and Nephew Healthcare, Hull, UK), silver carboxymethylcellulose (Aq) (AQUACEL Ag, ConvaTec, Bristol-Myers Squibb, Skillman, NJ), silver sulfadiazine (M) (Medifoam Silver, Biopol Global Co, Ltd, Seoul, Korea), nanocrystalline silver (P) (PolyMem Silver, Ferris Mfg Corp, Fort Worth, TX), Ilvadon cream (I) (Ildong Pharaceutical Co, Ltd, Seoul, Korea), and 10% povidone iodine (B) (Betadine, Sung Kwang Pharmaceutical Co Ltd, Gyeonggi-Do, Korea) as a control agent. Blood was collected from all animals to measure the hematological effects. The skin, spleen, liver, and kidneys of each rat were biopsied and used to make paraffin sections in which the silver deposition was measured using energy-dispersive spectrometry (EDS).. Fifteen days after wounding, only the Ac, P, and I groups differed significantly (P < 0.05) from the B group. The glutamic-oxaloacetic transaminase, blood urea nitrogen, and alkaline phosphatase levels differed significantly (P < 0.05) between the SD and STZ rats. No silver deposition was found in any organ.. The silver dressings induced slight liver damage in the STZ-rats. Although changes in serum chemistry caused by silver were seen, this did not indicate silver deposition in the organ as the EDS did not show excess levels. The risk of silver deposition appears to be low. The hazards of silver-containing dressing products in MRSA-infected wounds were insignificant.

Topics: Animals; Anti-Infective Agents, Local; Bandages; Carboxymethylcellulose Sodium; Diabetes Mellitus, Experimental; Metal Nanoparticles; Methicillin-Resistant Staphylococcus aureus; Rats; Rats, Sprague-Dawley; Silver; Silver Sulfadiazine; Staphylococcal Infections; Wound Healing; Wounds and Injuries

There is a growing demand for an appropriate and safe antimicrobial dressing to treat infected deep wounds. An amorphous gel formulation (SNP-CMC), containing silver nanoparticles (SNPs) and carboxymethylcellulose (CMC), was prepared in one step by the reduction of silver nitrate in situ. Spectrophotometric and microscopic analysis revealed that the SNPs were 7-21 nm in diameter. In simulated wound experiments, SNP-CMC gel was found to absorb 80.48 ± 4.69% w/w of saline and donate 17.43 ± 0.76% w/w of moisture within 24h indicating its dual fluid affinity. Cytocompatibility of the gel was assessed by proliferation studies with primary human skin cells. The antimicrobial activity studies showed that SNP-CMC containing 50 ppm of SNPs was effective against the growth of both Gram negative and Gram positive strains including methicillin-resistant Staphylococcus aureus (MRSA). These results indicate that SNP-CMC could be ideal for the treatment of deep infected wounds.

Topics: Anti-Bacterial Agents; Bandages; Carboxymethylcellulose Sodium; Cell Movement; Cell Proliferation; Cells, Cultured; Dermis; Fibroblasts; Humans; Hydrogels; Keratinocytes; Laxatives; Metal Nanoparticles; Methicillin-Resistant Staphylococcus aureus; Silver; Staphylococcal Infections; Wound Healing; Wound Infection

In this study, fumaric acid (FA) crosslinked carboxymethylcellulose (CMC) hydrogel (CMCF) based silver nanocomposites were coated on cotton fabric for antibacterial property for the first time. The performance of the nanocomposite treated cotton fabric was tested for different mixing times of hydrogel solution, padding times and concentrations of silver. The cotton fabrics treated with CMC hydrogel based silver nanocomposites demonstrated 99.9% reduction for both Staphylococcus aureus (Sa) and Klebsiella pneumonia (Kp). After one cycle washing processes of treated cotton fabric, there is no significant variation observed in antibacterial activity. From SEM and AFM analyses, silver particles in nano-size, homogenously distributed, were observed. The treated samples were also evaluated by tensile strength, thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR) analysis, fluid absorbency properties, and whiteness index. The treatment of cotton fabric with CMCF hydrogel did not affect the whiteness considerably, but increased the absorbency values of cotton.

Topics: Anti-Bacterial Agents; Carboxymethylcellulose Sodium; Cotton Fiber; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Klebsiella Infections; Klebsiella pneumoniae; Metal Nanoparticles; Nanocomposites; Silver; Staphylococcal Infections; Staphylococcus aureus; Tensile Strength

Staphylococci account for a large proportion of hospital-acquired infections, especially among patients with indwelling devices. These infections are often caused by biofilm-producing strains, which are difficult to eradicate and may eventually cause bacteremia and metastatic infections. Recent evidence suggests that mesenchymal stem cells can enhance bacterial clearance in vivo.. In this study, a rat model with carboxymethyl cellulose pouch infection was used to analyze the efficacy of bone marrow-derived mesenchymal stromal cells (BMSCs) against the methicillin-resistant Staphylococcus aureus.. The results showed that the administration of BMSCs effectively reduced the number of bacterial colonies and the expression of many cytokines and chemokines (such as interleukin [IL]-6, IL-1β, IL-10 and CCL5). Unlike the fibroblast control groups, the pouch tissues from the BMSC-treated rats showed the formation of granulations, suggesting that the healing of the wound was in progress.. The results indicate that the treatment of BMSCs can reduce methicillin-resistant S aureus infection in vivo, thereby reducing the inflammatory response.

Topics: Animals; Bone Marrow Cells; Carboxymethylcellulose Sodium; Cell- and Tissue-Based Therapy; Disease Models, Animal; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Methicillin-Resistant Staphylococcus aureus; Rats; Staphylococcal Infections

In order to improve the strength property and antimicrobial activity of paper simultaneously, we prepared a novel multifunctional agent based on carboxymethyl cellulose (CMC) by a simple two-stage method. The first stage was the oxidation of CMC to obtain the dialdehyde CMC (DCMC), and the second stage was the graft of guanidine hydrochloride (GH) onto DCMC to obtain DCMC-GH polymer. The strength property and antimicrobial activity of DCMC-GH-coated copy paper have been studied by the tensile test and inhibition zone method, respectively. The results showed that the dry strength index could increase about 20% after the paper was coated with DCMC-GH. The coating of DCMC-GH on paper also resulted in excellent antimicrobial activities against Escherichia coli and Staphylococcus aureus, and the inhibition zone became larger as the GH content grafted on DCMC increased. The novel DCMC-GH polymer would be a multifunctional coating agent for food packaging paper.

Topics: Anti-Bacterial Agents; Carboxymethylcellulose Sodium; Escherichia coli; Escherichia coli Infections; Food Packaging; Guanidine; Humans; Mechanical Phenomena; Oxidation-Reduction; Paper; Staphylococcal Infections; Staphylococcus aureus

Infection control and wound healing profiles of sodium carboxymethylcellulose (SCMC) films were investigated as a function of their anti-bacterial action, physical structures, polymer molecular weights and carboxymethyl substitution degrees. The films were prepared with in vitro polymer/film and in vivo microbe-colonized wound healing/systemic infection profiles examined. Adhesive high carboxymethyl substituted SCMC films aided healing via attaching to microbes and removing them from wound. Pseudomonas aeruginosa was removed via encapsulating in gelling low molecular weight SCMC film, whereas Staphylococcus aureus was trapped in tight folds of high molecular weight SCMC film. Incomplete microbe removal from wound did not necessary translate to inability to heal as microbe remnant at wound induced fibroblast migration and aided tissue reconstruction. Using no film nonetheless will cause systemic blood infection. SCMC films negate infection and promote wound healing via specific polymer-microbe adhesion, and removal of S. aureus and P. aeruginosa requires films of different polymer characteristics.

Topics: Animals; Carboxymethylcellulose Sodium; Male; Molecular Weight; Pseudomonas aeruginosa; Pseudomonas Infections; Rats, Sprague-Dawley; Staphylococcal Infections; Staphylococcus aureus; Wound Healing; Wound Infection

Methicillin-resistant Staphylococcus aureus (MRSA) may cause infections during wound dressing. We aimed to compare the antibacterial activities and wound-healing effects of commercially available silver-coated or silver-impregnated wound dressings on MRSA-infected wounds.. Full-thickness skin defects were made on the back of rats (N=108) and were infected with MRSA. The rats were divided into the following 6 groups according to the dressing used for the wounds: nanocrystalline silver (Acticoat), silver carboxymethylcellulose (Aquacel-Ag), silver sulfadiazine (Medifoam silver), nanocrystalline silver (PolyMem silver), silver sulfadiazine (Ilvadon), and 10% povidone iodide (Betadine). We analyzed the wound sizes, histological findings, and bacterial colony counts for the groups. We also inoculated the silver materials on Mueller-Hinton agar plates containing MRSA and compared the inhibition zones in the agar plates.. The order of the rate of wound-size decrease was Acticoat>Aquacel-Ag>PolyMem silver>Medifoam silver>Ilvadon>Betadine. The histological findings revealed that the Acticoat showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The order of the time required for wound healing was Acticoat>Aquacel -Ag>PolyMem silver>Ilvadon>Medifoam silver>Betadine. The bacterial colony counts reduced in all the groups, except in the Medifoam silver group. The order of the size of the inhibition zone was Acticoat>Aquacel-Ag>Ilvadon>PolyMem silver>Betadine>Medifoam silver.. Silver-coated or silver-impregnated wound dressings can be used for treating MRSAinfected wounds. Considering its superior efficacy in comparison to the efficacies of other silver-coated or silver-impregnated wound dressings, Acticoat should be preferentially used for the treatment of MRSA-infected skin wounds.

Topics: Animals; Bandages; Carboxymethylcellulose Sodium; Female; Metal Nanoparticles; Methicillin-Resistant Staphylococcus aureus; Povidone-Iodine; Rats; Rats, Sprague-Dawley; Silver; Silver Sulfadiazine; Skin; Staphylococcal Infections; Wound Healing

To compare the antimicrobial effectiveness of silver- and iodine-containing wound dressings against preformed mature biofilms of pathogenic wound bacteria grown in vitro.. Biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown within an in vitro flat bed perfusion biofilm model. Mature biofilms were removed and exposed to wound dressings containing either silver or iodine (Aquacel Ag and Iodozyme) within a static diffusion method, for up to 24 hours. This method was designed to reflect certain key features that determine antimicrobial activity within the wound. The numbers of viable bacteria surviving in the biofilms were determined at set time intervals over the test period.. Both test dressings exerted an antimicrobial effect against the target species biofilms, although the iodine dressing was more efficacious under the experimental conditions employed.. There are large and potentially significant differences (as measured in vitro) in the effectiveness of wound dressings containing broad-spectrum antimicrobial agents such as silver and iodine against specific types of bacterial biofilms.

Topics: Administration, Topical; Analysis of Variance; Bandages, Hydrocolloid; Biofilms; Carboxymethylcellulose Sodium; Cell Culture Techniques; Colony Count, Microbial; Drug Evaluation, Preclinical; Humans; Iodine Compounds; Linear Models; Pseudomonas Infections; Silver Compounds; Staphylococcal Infections; Time Factors; Wound Infection

Two strains of methicillin-resistant Staphylococcus aureus (MRSA), termed epidemic strains (EMRSA-15 and EMRSA-16), were used to evaluate the antimicrobial and barrier effect of four silver dressings (two silver donating and two non-silver-donating) available in the UK at the time of the study.. The moist surface of a blood agar plate was covered with 10(6) colony-forming units of the respective strain of MRSA, and dressings were applied to the surface and incubated at 37 degrees C for different time periods and the upper and lower surfaces subcultured for residual growth.. The nanocrystalline dressings (silver donating) were effective as a barrier from one hour until the study end (72 hours): no penetration of EMRSA-15 and EMRSA-16 through the dressing occurred. Moreover, the nanocrystalline dressings showed some antimicrobial activity at one hour in the areas underneath and surrounding the dressing until the study end. The remaining two dressings had no barrier effect and only demonstrated limited antimicrobial activity after 24 hours.. This in vitro study suggests that the nanocrystalline dressings are more effective than other silver dressings in terms of providing a barrier function and antimicrobial activity against EMRSA-15 and EMRSA-16.

Topics: Administration, Cutaneous; Agar; Anti-Infective Agents, Local; Carboxymethylcellulose Sodium; Culture Media; Drug Evaluation, Preclinical; Humans; Infection Control; Methicillin Resistance; Nanostructures; Polyesters; Polyethylenes; Silver; Staphylococcal Infections; Staphylococcus aureus; Time Factors; Wound Infection

In craniofacial surgery, alloplastic materials are used for correcting bony defects. Porous polymethylmethacrylate (PMMA) is a biocompatible and nondegradable bone cement. Porous PMMA is formed by the classic bone cement formulation of methylmethacrylate liquid and PMMA powder in which an aqueous biodegradable carboxymethylcellulose gel is dispersed to create pores in the cement when cured. Pores give bone the opportunity to grow in, resulting in a better fixation of the prostheses. We evaluated the long-term results (n = 14), up to 20 years, of augmentations and defect fillings in the craniofacial area, with special interest in possible side effects and bone ingrowth. The evaluation consisted of a questionnaire, a physical examination, and a computed tomography (CT) scan. There were no side effects that could be ascribed to the porous PMMA. Twelve CT scans showed bone ingrowth into the prostheses, proving the validity behind the concept of porous PMMA.

Topics: Biocompatible Materials; Bone Cements; Bone Substitutes; Carboxymethylcellulose Sodium; Facial Bones; Follow-Up Studies; Gels; Humans; Hypersensitivity; Necrosis; Patient Satisfaction; Physical Examination; Polymethyl Methacrylate; Porosity; Prosthesis-Related Infections; Reproducibility of Results; Retrospective Studies; Skull; Staphylococcal Infections; Surface Properties; Surveys and Questionnaires; Tomography, X-Ray Computed; Wound Healing