orabase and Skin-Ulcer

Topics: Carboxymethylcellulose Sodium; Debridement; Humans; Skin Ulcer; Wound Healing

Topics: Aged; Aged, 80 and over; Carboxymethylcellulose Sodium; Cutaneous Fistula; Enteral Nutrition; Equipment Design; Female; Gastric Fistula; Gastroscopy; Gastrostomy; Humans; Male; Middle Aged; Patient Selection; Risk Factors; Skin Care; Skin Ulcer; Wound Healing

Stomahesive skin-protection powder has been reported to be useful as a skin-care and skin-barrier product for the management of stomas. This study aimed to evaluate its efficacy, in terms of wound healing, moisture retention and pain management, as an alternative to conventional dressing materials. Both clinical and animal studies were undertaken.. The efficacy of the Stomahesive powder was tested by measuring the thickness of granulation tissue formed in a total skin defect in a db/db mouse model. We then compared the healing process using either the skin-protection powder or a conventional film dressing material. In the clinical study 17 patients with various intractable ulcers were treated with Stomahesive powder, and healing was evaluated.. In the mouse model, granulation tissue in the wounds treated with the powder was 2.86 times thicker than that of the wounds treated with the film dressing. In the clinical study, 16 out of 17 wounds healed completely.. The Stomahesive powder could be an effective treatment modality for contact ulceration, superficial ulcers with complex contours and morphology, and superficial ulcers contaminated by liquid faeces or vaginal discharge that have not responded to conventional dressings.. None.

Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Animals; Carboxymethylcellulose Sodium; Disease Models, Animal; Drug Combinations; Drug Evaluation; Female; Gelatin; Granulation Tissue; Humans; Male; Mice; Mice, Inbred Strains; Middle Aged; Occlusive Dressings; Pectins; Polyenes; Powders; Skin Care; Skin Ulcer; Statistics, Nonparametric; Wound Healing

Topics: Adhesives; Aged, 80 and over; Carboxymethylcellulose Sodium; Dermatitis, Allergic Contact; Drug Combinations; Gelatin; Humans; Male; Ostomy; Pectins; Polyenes; Polyethylenes; Skin Ulcer

The management of patients with highly-exuding wounds can often lead to the use of unreliable and costly treatments. Patients are frequently found to be at increased risk of infection and delayed healing, which results in a huge negative impact on their quality of life. In the political and health arena, reducing health-care costs yet maintaining high quality and productivity is high on the list. With current economic, health-care and political targets, it is crucial to address the importance of effective wound management, particularly the importance of managing exudate. Inappropriate management of wound exudate can lead to prolonged wound healing, peri-wound maceration and excoriation, and can result in deterioration of the wound.

Topics: Absorption; Aged; Aged, 80 and over; Bandages; Carboxymethylcellulose Sodium; Chronic Disease; Exudates and Transudates; Female; Humans; Male; Middle Aged; Pressure Ulcer; Rectal Diseases; Skin Ulcer; Surgical Wound Dehiscence; Wounds and Injuries

Fibrous materials in some modern absorbent wound dressings have the ability to sequester and retain bacteria; however, this ability varies according to the nature of the fibres. We studied the bacterial retention capacity of alginate and carboxymethylcellulose dressings, using an infected skin ulcer model on the backs of rats. Wound surfaces were inoculated with either Staphylococcus aureus or Pseudomonas aeruginosa at a concentration of 1.5 x 10(6) colony-forming units per wound. AQUACEL; Hydrofiber;, Kaltostat; or Sorbsan; were applied to the contaminated wounds for 12 h. Each dressing was then divided into two pieces. Total viable bacterial count within the dressing was calculated using one piece, and bacterial count released from the dressing into physiological saline was determined using the other piece, enabling bacterial retention rate to be calculated. Bacterial counts in tissue were also determined. Each dressing was tested on each of 10 wounds contaminated with each bacterium. Statistical analyses were performed using one-way analysis of variance (ANOVA) for replicated measures combined with Duncan's multiple comparison test. AQUACEL; Hydrofiber; dressing was most effective in its ability to retain both Staphylococcus aureus and Pseudomonas aeruginosa (p < 0.05). Bacterial counts in tissue showed no significant change with respect to pathogen or the type of dressing used. It can be concluded that the bacterial retaining ability of AQUACEL; Hydrofiber; dressing was found to be significantly higher than that of alginate dressings in an infected animal wound model.

Topics: Absorption; Alginates; Animals; Bandages; Carboxymethylcellulose Sodium; Glucuronic Acid; Hexuronic Acids; Male; Occlusive Dressings; Rats; Rats, Sprague-Dawley; Skin Ulcer

Topics: Aged; Bandages; Carboxymethylcellulose Sodium; Humans; Male; Polyurethanes; Rubber; Skin Ulcer

Topics: Abdominal Wall; Carboxymethylcellulose Sodium; Fistula; Humans; Ileostomy; Intestinal Fistula; Methylcellulose; Skin Ulcer; Wound Healing