orabase and Sjogren-s-Syndrome

The aim of this investigation was to describe and to compare the effectiveness of a CMC- and a mucin-containing saliva substitute. 22 post-radiation patients, 17 Sjögren's Syndrome patients and 3 patients with xerostomia of unknown origin used a CMC- and a mucin-containing saliva substitute, each for 1 week in an arbitrary sequence. Neither the patient, the assistant, nor the physician were aware of the substitute being used. Each patient had to complete a questionnaire at 3 different intervals during the trial. One of the conclusions of this study is that mucin-containing substitutes are preferred by patients when compared to CMC-containing substitutes.

Topics: Adolescent; Adult; Aged; Carboxymethylcellulose Sodium; Double-Blind Method; Female; Humans; Male; Methylcellulose; Middle Aged; Mouthwashes; Mucins; Radiation Injuries; Saliva, Artificial; Sjogren's Syndrome; Xerostomia

The stimulatory effect of a recently introduced saliva substitute (Saliment) on the parotid salivary secretion was experimentally investigated in 10 healthy individuals without signs or symptoms of xerostomia and in 11 patients with xerostomia due to Sjögren's syndrome. Further, in 15 patients with Sjögren's syndrome, the effect of Saliment on the sensation of xerostomia was examined in a double-blind clinical study with cross-over. The use of Saliment was followed by a significant stimulation in the parotid salivary secretion (P less than 0.01) and the subjection sensation of xerostomia was significantly reduced (P less than 0.01).

Topics: Adolescent; Adult; Aged; Carboxymethylcellulose Sodium; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Female; Glycerol; Humans; Male; Methylcellulose; Middle Aged; Parotid Gland; Saliva; Secretory Rate; Sjogren's Syndrome; Sorbitol; Time Factors; Xerostomia

Topics: Carboxymethylcellulose Sodium; Drug Combinations; Female; Fluorides; Humans; Methylcellulose; Middle Aged; Minerals; Saliva; Sjogren's Syndrome; Sodium Fluoride; Xerostomia