orabase and Severe-Combined-Immunodeficiency

orabase has been researched along with Severe-Combined-Immunodeficiency* in 1 studies

Other Studies

1 other study(ies) available for orabase and Severe-Combined-Immunodeficiency

Article	Year
Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anh Antiviral research, 1993, Volume: 21, Issue:3 A variety of biological response modifiers (BRMs) have provided antiviral protection to immunocompetent mice, and this prompted us to determine their efficacy against murine cytomegalovirus (MCMV) infection in immunocompromised mice-including the profoundly immunocompromised SCID mice and C57Bl/6 and B6D2F1 aged mice. SCID mice showed a marked decrease (> 20-fold) in resistance to MCMV, while there was a slight decrease (3-fold) in aged mice. In BRM antiviral protection studies, SCID mice were almost completely protected against MCMV infection by the pleiotropic immunomodulators, MVE-2 and pICLC, but much less by the more selective CSF-1. pICLC-induced IFN and NK cell cytotoxicity were maintained in SCID mice, suggesting that pleiotropic immunomodulatory effects may be required for antiviral protection in such a profoundly immunocompromised model. pICLC also effectively protected aged mice against lethal MCMV infection and effectively induced IFN. These results emphasize the potential for BRM treatment in immunocompromised hosts. Topics: Animals; Carboxymethylcellulose Sodium; Cytomegalovirus Infections; Cytotoxicity, Immunologic; Immunity, Innate; Immunologic Factors; Interferons; Killer Cells, Natural; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Poly I-C; Polylysine; Pyran Copolymer; Severe Combined Immunodeficiency	1993

Article

Year

Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anh

Antiviral research, 1993, Volume: 21, Issue:3

A variety of biological response modifiers (BRMs) have provided antiviral protection to immunocompetent mice, and this prompted us to determine their efficacy against murine cytomegalovirus (MCMV) infection in immunocompromised mice-including the profoundly immunocompromised SCID mice and C57Bl/6 and B6D2F1 aged mice. SCID mice showed a marked decrease (> 20-fold) in resistance to MCMV, while there was a slight decrease (3-fold) in aged mice. In BRM antiviral protection studies, SCID mice were almost completely protected against MCMV infection by the pleiotropic immunomodulators, MVE-2 and pICLC, but much less by the more selective CSF-1. pICLC-induced IFN and NK cell cytotoxicity were maintained in SCID mice, suggesting that pleiotropic immunomodulatory effects may be required for antiviral protection in such a profoundly immunocompromised model. pICLC also effectively protected aged mice against lethal MCMV infection and effectively induced IFN. These results emphasize the potential for BRM treatment in immunocompromised hosts.

Topics: Animals; Carboxymethylcellulose Sodium; Cytomegalovirus Infections; Cytotoxicity, Immunologic; Immunity, Innate; Immunologic Factors; Interferons; Killer Cells, Natural; Macrophage Colony-Stimulating Factor; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Poly I-C; Polylysine; Pyran Copolymer; Severe Combined Immunodeficiency

1993