orabase and Precancerous-Conditions

Oral lichen planus (OLP) is a chronic mucosal condition commonly encountered in clinical dental practice. Lichen planus is believed to represent an abnormal immune response in which epithelial cells are recognized as foreign, secondary to changes in the antigenicity of the cell surface. It has various oral manifestations, the reticular form being the most common. The erosive and atrophic forms of OLP are less common, yet are most likely to cause symptoms. Topical corticosteroids constitute the mainstay of treatment for symptomatic lesions of OLP. Recalcitrant lesions can be treated with systemic steroids or other systemic medications. However, there is only weak evidence that these treatments are superior to placebo. Given reports of a slightly greater risk of squamous cell carcinoma developing in areas of erosive OLP, it is important for clinicians to maintain a high index of suspicion for all intraoral lichenoid lesions. Periodic follow-up of all patients with OLP is recommended.

Topics: Carboxymethylcellulose Sodium; Carcinoma, Squamous Cell; Chronic Disease; Diagnosis, Differential; Humans; Immunosuppressive Agents; Lichen Planus, Oral; Mouth Neoplasms; Precancerous Conditions; Steroids; Tacrolimus

Oral cancer is a prevalent cancer in male worldwide. Oral potentially malignant disorders (OMPDs) are the oral mucosa lesions that have high malignant transformation rate to oral cancer. The mainstay for OMPDs treatment includes carbon dioxide (CO

Topics: Animals; Anti-Infective Agents, Local; Carboxymethylcellulose Sodium; Cell Line; Cell Line, Tumor; Cricetinae; Drug Repositioning; Gentian Violet; High-Throughput Screening Assays; Humans; Mouth Mucosa; Mouth Neoplasms; NF-kappa B; Phosphorylation; Precancerous Conditions; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

An experimental model is described whereby human and monkey cervical tissues may be maintained as organ cultures for 21 and 40 days, respectively. Inclusion of sodium carboxymethyl cellulose in the culture medium prolongs the survival time of tissues considerably. The sequential cytologic changes associated with herpesvirus hominis type II (HVH-II) infection are reported. These changes are considered in relation to the possible causal role of HVH-II infection in cervical carcinogenesis.

Topics: Animals; Carboxymethylcellulose Sodium; Culture Media; Epithelium; Female; Haplorhini; Herpes Simplex; Humans; Models, Biological; Organ Culture Techniques; Precancerous Conditions; Uterine Cervical Neoplasms

A method for induction of carcinoma in subcutaneously implanted bronchial autografts in dogs is described. Four to 6 weeks after successful bronchial autografting, 30 to 90 mg. amounts of 3-MC or B(a)P suspended in sterile saline solution containing 1 percent CMC was injected into the lumen of the graft. The mucosal changes were followed histologically by excision of biopsy specimens and cytologically by needle aspiration biopsies. Three dogs developed squamous cell carcinomas invading deep into the submucosal area as early as 13 to 30 weeks after the first carcinogen treatment. The remaining eight experimental dogs showed various grades of squamous cell metaplasia with atypia within 30 weeks. Subsequently examined specimens revealed atypical metaplastic and proliferative changes further advanced than those seen in the initial biopsy specimens. The advantages of this method for a better understanding of the development of bronchogenic carcinomas are discussed.

Topics: Animals; Benzopyrenes; Biopsy, Needle; Bronchi; Bronchial Neoplasms; Carboxymethylcellulose Sodium; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Dermatologic Surgical Procedures; Dogs; Drug Implants; Female; Male; Methylcholanthrene; Neoplasms, Experimental; Precancerous Conditions; Time Factors; Transplantation, Autologous