orabase and Peripheral-Nervous-System-Diseases

While pressure relief is a vital component of the treatment of neuropathic plantar foot ulcers, many patients are reluctant to wear offloading devices. Healing is more likely to occur if the patient is happy with its appearance and comfort.

Topics: Biomechanical Phenomena; Carboxymethylcellulose Sodium; Debridement; Foot Ulcer; Holistic Health; Humans; Male; Middle Aged; Nursing Assessment; Patient Compliance; Peripheral Nervous System Diseases; Pressure; Risk Factors; Shoes; Skin Care; Treatment Outcome; Walkers; Wound Healing

Perineural scar formation is responsible for pain and loss of function after surgical procedures. Neurolysis and application of anti-adhesion gels are required to restore a gliding surface. We tested a carboxymethylcellulose (CMC) and polyethylene oxide (PEO) gel on mouse sciatic nerve to describe its safety and efficacy.. Adult mice underwent a surgical procedure in which we burned the muscular bed of the sciatic nerve bilaterally (Burned group) and applied anti-adhesion gel to 1 of the nerves (Burned+gel group). After 3 weeks, we studied scar tissue by biomechanical and histological evaluation.. Both histological and biomechanical analysis showed that the gel reduced perineural scarring. The difference between the Burned and Burned+gel groups was statistically significant.. CMC-PEO gel can reduce perineural scar tissue. In histological section, scar tissue was present in both groups, but in the Burned+gel group a gliding surface was identified between scar and nerve.

Topics: Animals; Biomechanical Phenomena; Burns; Carboxymethylcellulose Sodium; Disease Models, Animal; Mice; Mice, Inbred ICR; Peripheral Nervous System Diseases; Polyethylene Glycols; Surface-Active Agents