orabase and Liver-Diseases

Carboxymethylcellulose (CMC) (1% in 0.9% NaCl, 0.2 ml/10 g ip) a common suspending agent, enhanced adriamycin (ADR) (15 mg/kg ip) toxicity when administered to mice 5 hr before the antibiotic. Compared with ADR alone, this combination treatment produced, after 7 days, an increase in lethality from 15 to 80%. The pathologic analysis of hearts, livers, kidneys, and small bowels was performed, revealing an increase in the incidence and severity of hepatic damage in mice receiving ADR + CMC. Furthermore, reduced glutathione (GSH) was measured in livers of all mice; the animals treated with CMC and ADR + CMC showed a significant (p less than 0.01) reduction of hepatic GSH in comparison with controls and ADR-alone-treated animals. These data further confirm a crucial protective role for GSH in ADR toxicity and prove that CMC exerts an important biochemical effect on hepatic GSH.

Topics: Animals; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Doxorubicin; Drug Interactions; Glutathione; Liver Diseases; Methylcellulose; Mice

A marked increase of serum transaminase activities, histological changes of livers similar to those seen in viral hepatitis in man, and inhibition of hepatic protein synthesis were observed in rats following a single injection of D-galactosamine-HCl. These galactosamine-induced phenomena were prevented by the pretreatment of polyriboinosinic acid-polyribocytidylic acid 24 h before the galactosamine administration.

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carboxymethylcellulose Sodium; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Liver Diseases; Male; Methylcellulose; Necrosis; Peptides; Poly I-C; Polylysine; Rats; Rats, Inbred Strains