orabase has been researched along with Hepatitis* in 1 studies
1 other study(ies) available for orabase and Hepatitis
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Comparative study on experimental autoimmune pancreatitis and its extrapancreatic involvement in mice.
The objective of the study was to study the relationship between autoimmune pancreatitis (AIP) and colitis in C57BL/6 interleukin 10-deficient (IL-10KO) mice and to compare the extrapancreatic involvement of AIP between IL-10KO and MRL/Mp mice that developed pancreatitis.. Six-week-old female IL-10KO and MRL/Mp mice were injected intraperitoneally with polyinosinic polycytidylic acid (poly I:C) twice weekly for 8 or 12 weeks, respectively. The mice were killed, and the severity of inflammation in the pancreas, colon, liver, bile duct, and salivary gland was assessed using histological scoring systems. T-cell subsets derived from IL-10KO mice with pancreatitis were adoptively transferred into recombination activating gene 2-deficient mice.. Administration of poly I:C induced pancreatitis and accelerated the development of colitis in IL-10KO mice. Pancreatitis was characterized by specific destruction of exocrine glands and the production of various autoantibodies. Involvement of the liver and bile duct was observed in both IL-10KO and MRL/Mp mice, but sialadenitis was present only in MRL/Mp mice. Adoptive transfer of CD4(+) T cells from AIP mice induced pancreatitis in recipient mice.. Pancreatitis in IL-10KO mice resembles human type 1 AIP and is not associated with colitis. Genetic background may affect susceptibility to extrapancreatic involvement in type 1 AIP. Topics: Adoptive Transfer; Animals; Autoantibodies; Autoimmune Diseases; Carboxymethylcellulose Sodium; CD4-Positive T-Lymphocytes; Cholangitis; Colitis; Disease Models, Animal; Exocrine Glands; Female; Hepatitis; Humans; Interferon Inducers; Interleukin-10; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Pancreatitis; Poly I-C; Polylysine; Severity of Illness Index; Sialadenitis | 2012 |